Refinement of Ibuprofen at 100K by Single-Crystal Pulsed Neutron Diffraction

Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid

“…19 Indeed, for mixtures between 0.42 and 0.65 molar ratios in ibuprofen, that is, around the eutectic composition, they did not observe any DSC signal corresponding to the liquidus curve. To explain this point, they suggested the existence of a (stearic acid)·(RS-ibuprofen) 2 compound. In fact, as seen in Figure 4, the DSC signals that correspond to the invariant and the liquidus overlap each other for composition near the eutectic point.…”

“…Therefore, a reduction in the dosage of ibuprofen Chemical structure of (a) S-ibuprofen and (b) R-ibuprofen drawn from the corresponding X-ray crystallographic information files. 1,2 The asymmetric carbon atom is represented by a gray motif.…”

Rapid Analysis of Organic Compounds by Proton‐Detected Heteronuclear Correlation NMR Spectroscopy with 40 kHz Magic‐Angle Spinning

“…[3] Most studies have employed simple onedimensional 13 C spectra, and resonances were assigned by comparison with solution-state spectra. [3,4] Unambiguous assignments are usually not possible when the solid and solution spectra differ substantially.…”

Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R,S)-ibuprofen/methyl-β-cyclodextrin inclusion complexes

“…Structural properties of IBP enantiomers and racemate have been widely characterized, by different experimental techniques and simulation [3][4][5][6][7][8][9][10][11]. In particular, it was observed that in crystal lattices of both (S)-and (R, S)-IBP two molecules are arranged to form a cyclic dimer through hydrogen bonds between their carboxylic groups COOH.…”