Refinement of an in Vitro Test for the Identification of Skin Corrosive Chemicals

Barlow, Aaron; Hirst, R. H.; Pemberton, Mark; Rigden, A.; Hall, Tony J.; Oliver, G.J.A.; Botham, Philip A.

doi:10.3109/15376519109044561

Cited by 20 publications

(3 citation statements)

References 6 publications

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“…Several investigations with more than one hundred chemicals have shown good correlations to rabbit dermal tolerance tests. 24,25 In an EEC validation study twelve chemicals have been tested by six laboratories in three in vitro assays, in two alternative human in vivo experiments and in the Draize test with rabbits.26 Results from two cytotoxicity assays were in good agreement with Draize test results concerning the ranking of the test substances. A good non-linear relation was additionally found between results of measurements of lowering of the electric resistance in rat skin slices and measurements of the transepidermal water loss in a human volunteer study.…”

Section: Skin Irritancymentioning

confidence: 54%

The Role of In Vitro Experiments in Animal Welfare

Rasmussen

1993

Hum Exp Toxicol

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Section: Skin Irritancymentioning

confidence: 54%

The Role of In Vitro Experiments in Animal Welfare

Rasmussen

1993

Hum Exp Toxicol

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“…The TER test (18)(19)(20)(21) is based on the observation that TER measurements have been shown to be capable of predicting severe cutaneous effects in vivo. Corrosive materials can be identified by their ability to produce a loss of integrity to the stratum corneum and the barrier function of the skin.…”

Section: The Ter Testmentioning

confidence: 99%

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

et al. 2008

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Liverpool John Moores University and FRAME recently conducted a research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with the REACH system. This report focuses on how to maximise the use of alternative methods (both in vitro and in silico) for skin corrosion and irritation testing within a tiered testing strategy. It considers the latest developments in in vitro testing, with particular reference to the reconstituted skin models which have now been now been successfully validated and independently endorsed as suitable for both skin corrosivity and irritancy testing within the EU.

show abstract

Section: The Ter Testmentioning

confidence: 99%

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

et al. 2007

View full text Add to dashboard Cite

Liverpool John Moores University and FRAME recently conducted a research project, sponsored by DEFRA, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with the REACH system. This report focuses on how to maximise the use of alternative methods (both in vitro and in silico) for skin corrosion and irritation testing within a tiered testing strategy. It considers the latest developments in in vitro testing, with particular reference to the reconstituted skin models which have now been now been successfully validated and independently endorsed as suitable for both skin corrosivity and irritancy testing within the EU.

show abstract

Refinement of an in Vitro Test for the Identification of Skin Corrosive Chemicals

Cited by 20 publications

References 6 publications

The Role of In Vitro Experiments in Animal Welfare

The Role of In Vitro Experiments in Animal Welfare

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

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