Referenzwerte für die Spirometrie bei Erwachsenen

Koch, Beate; Schäper, Christoph; Ittermann, Till; Völzke, Henry; Sb, Felix; Ewert, R.; Gläser, Sebastian

doi:10.1055/s-0029-1242688

Cited by 7 publications

(1 citation statement)

References 11 publications

(26 reference statements)

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“…Therefore, it is recommended to use a set of predicted values according to different authors. However, the most popular predicted values recommended by ERS (unchanged for over 20 years) are not fully representative for the Polish [ 27 ], Greek [ 2 ], Finish [ 17 ] Croatian [ 37 ], German [ 18 ], or Spain [ 11 ] populations.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism

et al. 2010

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Introduction The vagus nerve plays a special role in the control of respiratory system activity which represents the parasympathetic part of the autonomic nervous system. A small bronchial innervation by the sympathetic system also is observed, and there is a significant expression of adrenergic receptors, in particular β 2 receptors, in the airways. The development of genetics and molecular biology allows for a detailed study which can clarify the essential elements in the pathogenesis of many types of lung disease, as well as the physiological phenomena - bronchial smooth muscle tone and their contractile mechanism. Materials and methods The study involved 148 healthy male volunteers aged 20-26. In all subjects, gene polymorphism at nucleotide position 46 and 79 of β 2 -adrenergic receptor (β 2 -ADR) was assessed. According to the gene polymorphism data, we divided the whole examined population of males into 6 groups for further studies. Moreover, in all the subjects, we performed spirometry testing to verify their pulmonary functions. Results The basic values of spirometry tests in all subjects were in the range of normal values. The frequency of different genotypes in the gene polymorphism of the β 2 -adrenergic receptor at nucleotide positions 46 and 79 were typical for the Caucasian population. Analysis of the output values of spirometry, conducted in the particular groups based on their genotype, showed significant inter-group differences in the selected spirometry tests. Conclusions Our results may be useful in explaining the differences in the measured values of spirometric indices in healthy subjects in relation to the polymorphism of β 2 -ADR, and may also contribute to the verification of standards for spirometric indices for this selected group of young males in the Polish population.

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Section: Discussionmentioning

confidence: 99%

Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism

et al. 2010

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Systems Medicine as a Transforming Tool for Cardiovascular Genetics

Boerries

Zeller²

2019

Genetic Causes of Cardiac Disease

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Airflow limitation, lung volumes and systemic inflammation in a general population

Gläser¹,

Ittermann²,

Koch³

et al. 2011

Eur Respir J

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Although several levels of evidence have suggested an association between systemic inflammation and spirometric lung volumes, data addressing the potential interrelationship between airflow limitation and inflammatory markers are sparse and remain controversial.Potential associations between high-sensitivity C-reactive protein (hsCRP), fibrinogen and lung function were investigated in 1,466 individuals aged 25-85 yrs, representing a general population. Within this cross-sectional population, data on body plethysmography, spirometry, helium dilution and diffusing capacity of the lung for carbon monoxide (DL,CO) were analysed.After adjustment for potential confounding factors, such as smoking, obesity and cardiorespiratory fitness, there was an inverse association of hsCRP with forced expiratory and static lung volumes. In neither apparently healthy nor the entire population was inflammation associated with airflow limitation in central airways. In smokers only, higher hsCRP and fibrinogen were associated with an impaired DL,CO.This study shows that higher levels of hsCRP are associated with decreased lung volumes in a general population over a wide age range. A consistent interrelationship of central airflow limitation and inflammation was not verifiable. Smoking is related to an impaired DL,CO in association with an increase in systemic inflammation.

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Referenzwerte für die Spirometrie bei Erwachsenen

Cited by 7 publications

References 11 publications

Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism

Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism

Systems Medicine as a Transforming Tool for Cardiovascular Genetics

Airflow limitation, lung volumes and systemic inflammation in a general population

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