The high‐temperature creep–fatigue (CF) interaction on the service damage of P92 welded joint was uncovered based on the evolution of local creep behaviour by nanoindentation. The creep resistance and high‐angle grain boundary (HAGB) distributions of the different regions of welded joint were investigated for the specimens under individual creep (stress relaxation [RS]), fatigue and CF loadings interrupted at lifetime fractions of 10%, 20%, 30%, 60% and 100%. According to structure evolution including the changes of HAGB and dislocation densities during high‐temperature deformation, the local variation mechanism of creep behaviour at different microstructural zones was systematically discussed.