Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center

Júnior, Edward Araujo; Pires, Cláudio Rodrigues; Martins, Wellington P.; Nardozza, Luciano Marcondes Machado; Filho, Sebastião Marques Zanforlin

doi:10.1515/jpm-2013-0141

Cited by 5 publications

(4 citation statements)

References 12 publications

(17 reference statements)

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“…The 95 th NT thickness percentiles have been reported to be 2.1-3.2 mm, 2.14-2.3 mm, 1.57-2.10 mm, 1.00-2.90 mm, and 1.84-2.35 mm for a CRL between 45 mm and 80 mm in Japan, Korea, Brazil, Thailand, and China, respectively. [ 11 12 13 14 15 ] Our results were similar to the reported reference value range of Brazil. [ 13 ] Although there was no report from the Eastern Mediterranean region in this field, the values were not similar to the values reported from the Asian countries.…”

Section: Discussionsupporting

confidence: 88%

“…The median NT thicknesses has been reported to be 1.2-1.9 mm, 1.22-2.10 mm, and 1.19-1.73 mm for a CRL between 45 mm and 80 mm in Japan, Korea, and Brazil, respectively. [ 11 12 13 ] Our reported median value was lower than the other reports.…”

Section: Discussioncontrasting

confidence: 80%

“…One of the explanations for the reported great variety of NT thickness range is ethnic variation. [ 11 12 13 14 15 ] However, there are still controversies regarding the role of ethnicity on the value of NT. Some reported a significant role of ethnicity in this regard, whereas others did not support the association.…”

Section: Introductionmentioning

confidence: 99%

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Normal reference range of fetal nuchal translucency thickness in pregnant women in the first trimester, one center study

Sharifzadeh¹,

Adibi²,

Kazemi³

et al. 2015

J Res Med Sci

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Background:Considering that establishment of reference value of nuchal translucency (NT)-related to the crown rump length (CRL) during the first trimester will be helpful for determining an appropriate cutoff level for screening of increased NT thickness-related abnormalities, we determined the NT thickness and investigated its relation with different chromosomal and nonchromosomal abnormalities among a large sample size of pregnant Iranian women.Materials and Methods:In this analytic cross-sectional study, pregnant women who were in their first trimester were enrolled at their antenatal visit. Using an abdominal ultrasonography, the fetal NT thickness of the studied population was measured. Those with increased NT thickness were determined. The reference value of NT thickness (5th, 25th, 50th, 75th, and 95th percentiles) within each 5-mm range of CRL and during the 11th, 12th, and 13th gestational weeks were determined. The presences of the different chromosomal and nonchromosomal abnormalities were compared in women with different percentiles of NT thickness who underwent amniocentesis and those who did not.Results:1,614 pregnant women were evaluated. The mean NT thickness was 1.30 ± 0.54 mm. Increased NT thickness >2 mm and >95th percentile according to their gestational age (GA) was detected in 89 (5.5%) and 58 (3.6%) pregnant women. The reference 95th percentile value range for NT was 1.8-2.35 and increased NT thickness according to our obtained values was associated significantly with chromosomal abnormalities.Conclusion:The obtained reference range in our studied population was different from that reported for other ethnic groups and it is suggested that using this values are more favorable for screening of chromosomal abnormalities during the first trimester of pregnancy than the recommended single cutoff value.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 80%

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Normal reference range of fetal nuchal translucency thickness in pregnant women in the first trimester, one center study

Sharifzadeh¹,

Adibi²,

Kazemi³

et al. 2015

J Res Med Sci

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“…This is almost similar to a finding reported by Olufemi ., (2014) in Ogun state, Nigeria, where they reported a mean NTT of 2.2mm. Similarly, the median of NTT of a CRL value within 45 mm -80 mm was lower than findings reported in Korea (Chung ., 2003), Japan (Junich ., 2012), and Brazil (Júnior ., 2014). However, this subtle variation may be attributed to either ethnic, geographic, or methodological differences between the studies.…”

Section: Key: Ntt: Nuchal Translucency Thickness Ga: Gestation Agementioning

confidence: 99%

Sonographic Dimension of Fetal Nuchal Translucency in Kano Metropolis: A single Center Study

Abba¹,

Aisha²,

Barde³

2022

bjnhc

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Background: Nuchal Translucency Thickness (NTT) is a hypo-echoic region of subcutaneous fluid accumulation in the posterior neck region at the level of the cervical spine between the skin and soft tissues and is mostly found at 11–13 weeks of fetal gestation. It is visualised with a mid-sagittal ultrasound view of the fetus in a neutral position. The NTT provides a risk assessment for chromosomal abnormalities which has been used as a marker of possible fetal abnormalities. Hence, the justification to conduct the present study. Aim: To establish the mean fetal nuchal translucency thickness with corresponding gestational age (GA) and to assess the correlation between Crown Rump Length (CRL), GA, and NTT among apparently healthy pregnant women. Methods: A cross-sectional study was conducted among 150 apparently normal consenting pregnant women in their late first trimester in the Radiology department of Muhammad Abdullahi Wase Teaching Hospital, Kano from February 2021 to May 2021. Ultrasonographic measurements of the crown-rump length (CRL), gestational age (GA), and NTT were performed on pregnancies within 11 to 13 weeks of gestation. Their 2.5th, 25th, median and 97.5th percentiles of the NTT, GA, and CRL were determined using SPSS version 23 (IBM, 2017). Indicate correlation… as part of the analysis. Results: Median NTT at 11-13+6 weeks of gestation was found as 3.0±0.10mm. The NT thickness increased with increasing CRL and gestational week in the first trimester. The correlation coefficient between NTT and CRL as well as GA were 0.472 and 0.451, respectively. Conclusion: The overall mean NTT in Kano fetuses was determined. These should be useful for first-trimester screening in ruling out potential fetal chromosomal abnormalities in Kano, Nigeria.

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Valores de referencia de la translucencia nucal en Panamá y su comparación con diferentes regiones del mundo

Herrera

Cubilla-Batista

Britton

et al. 2021

Clínica e Investigación en Ginecología y Obstetricia

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Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center

Abstract: The reference values for NT thickness were determined for a sample of the Brazilian population. Further studies are required to evaluate the real need for including these values in first-trimester screening for chromosomal defects in Brazil.

Cited by 5 publications

References 12 publications

Normal reference range of fetal nuchal translucency thickness in pregnant women in the first trimester, one center study

Normal reference range of fetal nuchal translucency thickness in pregnant women in the first trimester, one center study

Sonographic Dimension of Fetal Nuchal Translucency in Kano Metropolis: A single Center Study

Valores de referencia de la translucencia nucal en Panamá y su comparación con diferentes regiones del mundo

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