Reference values of nuchal fold thickness in an Iranian population sample

Kazemi, Kimia; Adibi, Atoosa; Hovsepian, Silva

doi:10.4103/jrms.jrms_357_18

J Res Med Sci

2018

DOI: 10.4103/jrms.jrms_357_18

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Reference values of nuchal fold thickness in an Iranian population sample

Kimia Kazemi

Atoosa Adibi

Silva Hovsepian

Abstract: Background:Considering that ethnicity and gestational age (GA) could affect the value of nuchal fold thickness (NFT) in mid-trimester, we aimed to determine the reference intervals of NFT values for each gestational week from 16 to 24 weeks of pregnancy among a group of Iranian pregnant women.Materials and Methods:In this cross-sectional study, medical files of pregnant women who underwent fetal anomaly scanning at 16–24 weeks of gestation were reviewed and the following data were extracted: GA, value of NFT, … Show more

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“…Nuchal fold thickness (NFT), a major soft maker for aneuploidy, has a detection rate of 4.17% in the present study. The NFT is also defined as nuchal edema in the second trimester and is a non-structural marker with suitable sensitivity and specificity[Kazemi et al 2018]. The existence of echogenic bowel (EB) during second-trimester ultrasound screening is a significant finding indicating abnormal development[ Sal et al.…”

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confidence: 99%

Prenatal Screening Of Foetal Chromosomal Disorders Using Maternal Serum Biochemical Markers And Karyotyping Among Indian Population

Appavu,

Padhiar,

Nandagopal

et al. 2023

JAZ

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Background: Prenatal screening for aneuploidy during the first and second trimesters is a part of obstetric care. Because invasive procedures carry a high risk of miscarriage, these screening tests in high-risk pregnancies for aneuploidies are essential for determining the abnormality. The present study aimed to determine the predictive accuracy of prenatal screening tests and USG soft markers concerning maternal age groups, the incidence of chromosomal abnormalities, and the trends of screening tests chosen by obstetricians for women undergoing prenatal chromosome analysis prenatal screening. Methods: 2280 Pregnant women were referred for prenatal screening tests in 2019-2020 by a well-established medical diagnostic laboratory, Lifecell International Private Limited. The sample has been analyzed based on the maternal age, screening tests, clinical indicators, karyotype interpretation, and type of chromosomal abnormalities. All the data were examined with the aid of SPSS 16.0 and EXCEL. Results: 46.40% of women used TMT, 7.28% used DMT, and 3.82% used a combined first-trimester test in the present study. Positive predictive accuracy of the first trimester combined test is the highest (33.33%). Among 2280 women screened positive for aneuploidy based on different prenatal screening procedures, only 149 (6.5%) were found to have an abnormal karyotype, and the remaining 2131(93.5%) had a normal karyotype. USG marker in the absence of biochemical markers can detect considerable aneuploidy risk during the first and second trimesters. Conclusion:The present study shows that in India second trimester

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confidence: 99%

Prenatal Screening Of Foetal Chromosomal Disorders Using Maternal Serum Biochemical Markers And Karyotyping Among Indian Population

Appavu,

Padhiar,

Nandagopal

et al. 2023

JAZ

View full text Add to dashboard Cite

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Effect of Prophylactic Embolization on Patients With Blunt Trauma at High Risk of Splenectomy

et al. 2020

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IMPORTANCE Splenic arterial embolization (SAE) improves the rate of spleen rescue, yet the advantage of prophylactic SAE (pSAE) compared with surveillance and then embolization only if necessary (SURV) for patients at high risk of spleen rupture remains controversial. OBJECTIVE To determine whether the 1-month spleen salvage rate is better after pSAE or SURV. DESIGN, SETTING, AND PARTICIPANTSIn this randomized clinical trial conducted between February 6, 2014, and September 1, 2017, at 16 institutions in France, 133 patients with splenic trauma at high risk of rupture were randomized to undergo pSAE or SURV. All analyses were performed on a per-protocol basis, as well as an intention-to-treat analysis for specific events.INTERVENTIONS Prophylactic SAE, preferably using an arterial approach via the femoral artery, or SURV. MAIN OUTCOMES AND MEASURESThe primary end point was an intact spleen or a spleen with at least 50% vascularized parenchyma detected on an arterial computed tomography scan at 1 month after trauma, assessed by senior radiologists masked to the treatment group. Secondary end points included splenectomy and pseudoaneurysm, secondary SAE after inclusion, complications, length of hospital stay, quality-of-life score, and length of time off work or studies during the 6-month follow-up.RESULTS A total of 140 patients were randomized, and 133 (105 men [78.9%]; median age, 30 years [interquartile range, 23-47 years]) were retained in the study. For the primary end point, data from 117 patients (57 who underwent pSAE and 60 who underwent SURV) could be analyzed. The number of patients with at least a 50% viable spleen detected on a computed tomography scan at month 1 was not significantly different between the pSAE and SURV groups (56 of 57 [98.2%] vs 56 of 60 [93.3%]; difference, 4.9%; 95% CI, −2.4% to 12.1%; P = .37). By the day 5 visit, there were significantly fewer splenic pseudoaneurysms among patients in the pSAE group than in the SURV group (1 of 65 [1.5%] vs 8 of 65 [12.3%]; difference, −10.8%; 95% CI, −19.3% to −2.1%; P = .03), significantly fewer secondary embolizations among patients in the pSAE group than in the SURV group (1 of 65 [1.5%] vs 19 of 65 [29.2%]; difference, −27.7%; 95% CI, −41.0% to −15.9%; P < .001), and no difference in the overall complication rate between the pSAE and SURV groups (19 of 65 [29.2%] vs 27 of 65 [41.5%]; difference, −12.3%; 95% CI, −28.3% to 4.4%; P = .14). Between the day 5 and month 1 visits, the overall complication rate was not significantly different between the pSAE and SURV groups (11 of 59 [18.6%] vs 12 of 63 [19.0%]; difference, −0.4%; 95% CI, −14.4% to 13.6%; P = .96). The median length of hospitalization was significantly shorter for patients in the pSAE group than for those in the SURV group (9 days [interquartile range, 6-14 days] vs 13 days [interquartile range, 9-17 days]; P = .002).CONCLUSIONS AND RELEVANCE Among patients with splenic trauma at high risk of rupture, the 1-month spleen salvage rate was not statistically different between patients...

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Reference values of nuchal fold thickness in an Iranian population sample

Cited by 2 publications

References 30 publications

Prenatal Screening Of Foetal Chromosomal Disorders Using Maternal Serum Biochemical Markers And Karyotyping Among Indian Population

Prenatal Screening Of Foetal Chromosomal Disorders Using Maternal Serum Biochemical Markers And Karyotyping Among Indian Population

Effect of Prophylactic Embolization on Patients With Blunt Trauma at High Risk of Splenectomy

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