Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea

Lee, Jeong Soo; Kim, Na Young; Na, Se Hee; Youn, Young Hoon; Shin, Cheung Soo

doi:10.1097/md.0000000000011138

Cited by 215 publications

(200 citation statements)

References 15 publications

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“…NLR showed a quadratic relationship with age, such that NLR was highest in chimpanzees between 25 and 35 years old, and was lower in both young and old individuals. This is in contrast with some findings in humans, which show that NLR increases linearly with old age in healthy populations, suggesting increased risk for inflammation [1, 3, 6]. The most parsimonious explanation for these data may be that chimpanzees with lower NLRs reach older ages precisely because they maintain better health, and thus, have lower NLR values.…”

Section: Discussioncontrasting

confidence: 84%

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Neutrophil to Lymphocyte Ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age, and rearing

Webb

Schapiro

Sherwood

et al. 2020

Preprint

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0In humans, neutrophil to lymphocyte ratio (NLR) has been used as a clinical tool in diagnosis 3 1 and/or prognosis of a variety of cancers and medical conditions, as well as in measuring 3 2 physiological stress over time. Given the close phylogenetic relationship and physical similarities 3 3 between humans and apes, NLR may similarly be a useful diagnostic tool in assessing 3 4chimpanzee health. Only one study has examined NLR in apes, reporting that NLR increased 3 5 with age and was affected by body-mass index and sex. In the current study, we examined 3 6 changes in NLR data from longitudinal health records for 443 chimpanzees in two captive 3 7 chimpanzee populations. Using these data, we analyzed intra-individual changes and inter-3 8 individual differences in NLR as a function of age, rearing history, and sex. Contrary to previous 3 9 studies in humans and the one previous study in chimpanzees, NLR values did not change over a 4 0 10-year timespan within individual chimpanzees. However, cross-sectional comparisons revealed 4 1 a significant quadratic relationship between age and NLR with the highest values during mid-life 4 2 (20-30 years of age) and the lowest values in younger and older individuals. Additionally, males 4 3 and mother-reared individuals had higher NLR than females and nursery-reared chimpanzees, 4 4respectively. Lastly, males and those with higher NLR values died at younger ages. These 4 5 findings may suggest that NLR can be used a predictor of longevity in chimpanzees. However, 4 6given the complexities of these relationships, more research is needed to determine the utility of 4 7 NLR as a diagnostic health tool for use in chimpanzees. 4 8

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Section: Discussioncontrasting

confidence: 84%

“…Other studies in healthy humans have found that NLR is moderately heritable (36%) [4], differs as a function of racial disparities in the United States population [2], and that males have higher NLR than females [4] . Average NLR ranges from 1.5 to 2.8 in humans, with reference ranges between 1.1 and 4.5 [1-6].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age, and rearing

Webb

Schapiro

Sherwood

et al. 2020

Preprint

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show abstract

“…41 Although PLR has been shown to be associated with prognosis of lung cancer in previous studies, studies on a predictive role of PLR in development of lung cancer are currently limited. [29][30][31][32] Previous studies reported a sex difference in PLR, with higher PLR in women than in men, 42,43 but studies address sex differences in the relationship between PLR and lung cancer risk are scarce. Although the mechanisms of sex-related differences in PLR are not fully understood, several factors, such as estrogen and low iron saturation in menstruating women, may affect platelet counts.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Kang

Chang

Ahn

et al. 2019

Intl Journal of Cancer

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Neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor prognosis in patients with lung cancer, but the predictive role of NLR on the risk of developing lung cancer is unknown. We investigated the association between NLR and lung cancer mortality in lung cancer‐free adults. A cohort study was performed with 527,124 Korean adults who were free of lung cancer and were followed for up to 16 years. Vital status and lung cancer‐related deaths were ascertained through national death records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer mortality were estimated using a Cox proportional hazards model. During 4,567,495.8 person‐years of follow‐up, 574 lung cancer deaths were identified. A higher NLR was positively associated with lung cancer mortality. The multivariable‐adjusted HR (95% CI) for lung cancer mortality comparing quintiles 2, 3, 4 and 5 of NLR to the lowest quintile were 1.26 (0.96–1.67), 1.23 (0.93–1.63), 1.33 (1.01–1.75) and 1.47 (1.13–1.92), respectively. The highest risk of lung cancer mortality was also observed in the highest NLR quintile among never‐smokers and low‐risk individuals after adjusting for lung function and other possible confounders. Platelet‐to‐lymphocyte ratio showed an inverse J‐shaped association with lung cancer mortality in men but the trends in women, low‐risk individuals or never‐smokers were neither linear nor U‐shaped. In this large cohort of young and middle‐aged individuals, NLR was independently associated with increased risk of lung cancer mortality in low‐risk individuals, indicating a role of systemic inflammation in lung cancer mortality in our study population.

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“…The data collected was entered in Microsoft Excel and analysed using SPSS V. 16. Descriptive analysis was done by calculating frequencies and proportions.…”

Section: Resultsmentioning

confidence: 99%

“…The mean NLR across all ages in men and women was 1.63 and 1.66, respectively. 16 The association of neutrophilic leucocytosis with bacteraemia and lymphocytosis with viremia is well known. 13 In the current study, the NLR was found to be higher in patients with bacterial infection compared to those with viral infection.…”

Section: Discussionmentioning

confidence: 99%

The role of neutrophil/lymphocyte ratio in predicting the severity of sepsis in a tertiary care hospital in South India: a retrospective study

George¹,

Thomas²,

Gaffoor³

2020

Int J Res Med Sci

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Background: Sepsis, a syndrome of dysregulated host response to infection leading to life-threatening organ dysfunction, is having a substantial burden in health system. The outcome in sepsis is often time dependent. None of the clinical manifestations nor the age-old markers like ESR, CRP, etc. have proven diagnostic or prognostic of sepsis. This study aims to assess the role of neutrophil: lymphocyte ratio (NLR) in assessing the severity of sepsis within the initial 24 hrs of admission. Methods: Authors did a retrospective observational study in 208 sepsis patients admitted in the MDICU. The NLR was calculated and the study population was grouped into those with an NLR of more than or equal to 5 and those with less than 5. The patients were also grouped based on the number of organs impaired due to sepsis. The association between these groups were then assessed. Results: 46 patients (60.5%) with single organ involvement had NLR <5; 30 patients (39.5%) had NLR >5; 27 patients (42.2%) with two organ involvement had NLR <5 and 37 patients (57.8%) had NLR >5. Among patients with more than two organ involvement, 8 patients (21.6%) had NLR <5 and 29 patients (78.4%) had NLR >5. It was found that there is statistically significant association between increase in number of organs involved and NLR more than 5. The chi square test value was 15.691 with a p value was less than 0.001. Conclusions: In the current study, we have evaluated the role of NLR in sepsis. NLR calculated on the day of admission is a simple parameter that helps to stratify patients into severe risk category. A significant association was found with higher NLR and the number of organs impairment in sepsis.

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Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea

Cited by 215 publications

References 15 publications

Neutrophil to Lymphocyte Ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age, and rearing

Neutrophil to Lymphocyte Ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age, and rearing

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

The role of neutrophil/lymphocyte ratio in predicting the severity of sepsis in a tertiary care hospital in South India: a retrospective study

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