Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Koo, Bon Sang; Lee, Dong Hoon; Kang, Philyong; Jeong, Kang Jin; S, Lee; Kim, Kijin; Lee, Youngjeon; Huh, Jae Won; Kim, Younghyun; Park, Sang Je; Jin, Yeung Bae; Kim, Sun-Uk; Son, Yeonghoon; Lee, Sang-Rae

doi:10.1186/s42826-019-0006-0

Cited by 49 publications

(70 citation statements)

References 26 publications

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“…The obtained mean serum ALP values for both sexes in this study were lower compared to previous reports. 6,8 However, the result in this study agrees with the reports that ALP serum levels were significantly higher in adult males than in the adult females. 2,5,8 One young mature male monkey, with body weight of ies on cynomolgus monkeys also reported ALP values higher than 1000 IU/L.…”

Section: Discussionsupporting

confidence: 92%

“…6,8 However, the result in this study agrees with the reports that ALP serum levels were significantly higher in adult males than in the adult females. 2,5,8 One young mature male monkey, with body weight of ies on cynomolgus monkeys also reported ALP values higher than 1000 IU/L. 8,13,14 The serum of monkeys also appeared yellowish suggestive of the free bilirubin circulating in the blood.…”

Section: Discussionsupporting

confidence: 92%

“…7 Creatine values for both sexes in this study was higher compared to previous reports. 2,6,8,14 but comparable to the baseline values reported earlier. 15 Low glucose level was observed in caged female monkeys because they ran during catching and trapping for physical restraint which resulted to a lower mean in females compared to males.…”

Section: Discussionsupporting

confidence: 88%

“…2,5,8 One young mature male monkey, with body weight of ies on cynomolgus monkeys also reported ALP values higher than 1000 IU/L. 8,13,14 The serum of monkeys also appeared yellowish suggestive of the free bilirubin circulating in the blood. 9,10 The mean TBil was also higher in females compared to males which agrees with the previous study.…”

Section: Discussionmentioning

confidence: 98%

“…15 The gamma-glutamyl transferase (GGT) enzyme was also higher compared to previous reports. 3,6,8 All sera collected were icteric which was suspected to be due to cholestasis as a result of once a day feeding management. It was reported that nutrition and fasting affected the plasma bilirubin concentration in squirrel monkeys.…”

Section: Discussionmentioning

confidence: 99%

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Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

Cardenio

Acorda

Lastica-Ternura

2020

J of Medical Primatology

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Diagnostic tools are infrequently used in assessing health conditions of rescued wildlife such as the long-tailed macaques in local wildlife rehabilitation and rescue centers in the Philippines. Health assessment of recently surrendered and rescued long-tailed macaques is limited to physical examination. Diagnostic tools such as serum biochemistry and diagnostic imaging are not readily present and performed upon arrival of new monkeys and during regular general health checkup of long-tailed macaques. These diagnostic tools are important in evaluating the general health condition of the animal, disease diagnosis, and monitoring. Serum evaluation is infrequently performed in rescued monkeys and is limited only to those being kept in laboratories. Serum biochemistry values for laboratory-kept long-tailed macaques originated from Mauritius, 1 China, 2 and Cambodia 3 were previously reported. Sex-related differences were observed on serum biochemistry values of healthy male and female macaques in previous studies. 4-8 The differences in serum biochemistry values observed in monkeys from a different country of origin might have been caused by their exposure to different dietary constituents and environment. Moreover, many factors including climate, genetic background, and age of the animals could affect the results. 4 In addition, increase or

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

Cardenio

Acorda

Lastica-Ternura

2020

J of Medical Primatology

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Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

et al. 2021

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Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point-of-care (POC) biomarkers to predict risk and guide decision making are lacking. In this investigation, we characterized trends in POC biomarkers during NMP and compared primate donation after circulatory death (DCD) livers with short and prolonged warm ischemic injury. Following asystole, livers were subjected to either 5 minutes (DCD-5min, n = 4) or 45 minutes (DCD-45min, n = 4) of warm ischemia time. Livers were flushed with heparinized UW solution, and preserved in cold storage before NMP. During flow-controlled NMP, circulating perfusate and tissue biopsies were collected at 0, 2, 4, 6, and 8 hours for analysis. DCD-45min livers had greater terminal portal vein pressure (8.5 vs. 13.3 mm Hg, P = 0.027) and terminal portal vein resistance (16.3 vs. 32.4 Wood units, P = 0.005). During perfusion, DCD-45min livers had equivalent terminal lactate clearance (93% vs. 96%, P = 0.344), greater terminal alanine aminotransferase (163 vs. 883 U/L, P = 0.002), and greater terminal perfusate gamma glutamyltransferase (GGT) (5.0 vs. 31.7 U/L, P = 0.002). DCD-45min livers had higher circulating levels of flavin mononucleotide (FMN) at hours 2 and 4 of perfusion (136 vs. 250 ng/mL, P = 0.029; and 158 vs. 293 ng/mL, P = 0.003; respectively). DCD-5min livers produced more bile and demonstrated progressive decline in bile lactate dehydrogenase, whereas DCD-45min livers did not. On blinded histologic evaluation, DCD-45min livers demonstrated greater injury and necrosis at late stages of perfusion, indicative of nonviability. Conclusion: Objective criteria are needed to define graft viability during NMP. Perfusate lactate clearance does not discriminate between viable and nonviable livers during NMP. Perfusate GGT and FMN may represent POC biomarkers predictive of liver injury during NMP. (Hepatology Communications 2021;0:1-16).

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Seasonal Variability of Biochemical Parameters in Female Cynomolgus Macaques (Macaca fascicularis)

et al. 2022

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Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Cited by 49 publications

References 26 publications

Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

Correlations of serum biochemistry profile with ultrasonic histogram of liver, gallbladder, and kidneys and morphometry of rescued long‐tailed macaques (Macaca fascicularis)

Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

Seasonal Variability of Biochemical Parameters in Female Cynomolgus Macaques (Macaca fascicularis)

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