Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study

Lelis, Deborah de Farias; Calzavara, João Vitor Santos; Santos, Raul D.; Spósito, Andrei C.; Griep, Rosane Härter; Barreto, Sandhi Maria; Molina, María del Carmen Bisi; Schmidt, María Inês; Duncan, Bruce Bartholow; Benseñor, Isabela M.; Lotufo, Paulo A; Mill, José Geraldo; Baldo, Marcelo Perim

doi:10.1016/j.jacl.2021.07.005

Cited by 12 publications

(14 citation statements)

References 56 publications

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“…Moreover, combining the two lipid measures into one as the ratio of TG to HDL-C has been proved to be a reliable indicator for metabolic syndrome, insulin resistance, with direct implications in endothelial damage and atherosclerosis ( 5 , 6 , 16 , 17 ). Reference values for TG/HDL-C ratio and its association with cardiometabolic diseases in a mixed adult population were also recently identified ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study

Luca¹,

Temporelli

Colivicchi

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSeveral studies have reported that the combination of high TG and low HDL-C, as simplified by the TG/HDL-C ratio, was a predictor of cardiovascular disease independent of LDL-C level. Nevertheless, poor data are available on the predictive role of TG/HDL-C ratio in very high risk (VHR) patients with chronic coronary syndromes (CCS).MethodsUsing the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG/HDL-C ratio and baseline clinical characteristics, pharmacological treatment, and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of CCS patients at VHR.ResultsVHR patients with both TG and HDL-C levels available were grouped in tertiles of TG/HDL-C ratio: low (TG/HDL-C ratio <2, n = 967), middle (TG/HDL-C ratio 2–3.3, n = 1,071) and high (TG/HDL-C ratio >3.3, n = 1,028). At 1 year from enrolment, 232 (7.6%) patients presented a MACCE, with a higher incidence in the higher tertile, even though not statistically significant (6.0, 8.2, and 8.4% in the low, middle and high tertile, respectively; p = 0.08). At multivariable analysis, the TG/HDL-C ratio in tertiles did not result an independent predictor of the MACCE (p = 0.29) at 1-year follow-up (HR: 1.30; 95% CI: 0.93–1.82; p = 0.12 middle vs. lower tertile, and HR: 1.22; 95% CI: 0.87–1.72; p = 0.25 higher vs. lower).ConclusionsIn the present large, nationwide cohort of CCS patients at VHR a high TG/HD ratio did not emerge as independent predictor of MACCE at 1 year. Further studies with a longer follow-up are needed to better define the prognostic role of TG/HDL ratio in CCS.

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Section: Discussionmentioning

confidence: 99%

Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study

Luca¹,

Temporelli

Colivicchi

et al. 2022

Front. Cardiovasc. Med.

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“…Furthermore, a Spanish cohort study found that in men, those in the top quintile of the TG/HDL-C ratio were two times more likely than those in the bottom quintile to develop HTN, suggesting an association between TG/HDL-C and incident HTN ( 17 ). The ELSA-Brasil cohort study showed that the defined TG/HDL-C cut-offs (males: 2.6; females: 1.7) are reliable with good clinical applicability for detecting cardiometabolic conditions, including obesity and increased WC, in a multiethnic population ( 8 ). Overall, the findings of our study are consistent with those of other studies.…”

Section: Discussionmentioning

confidence: 99%

“…In Taiwan, according to 2005-2008 data, the prevalence of being overweight and obese among adults was 44.1% and was significantly higher than that in Japan, South Korea, and other neighboring Asian countries (6,7). Obesity has been reported to be associated with the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and CKD in addition to dyslipidemia (8,9). Dyslipidemia, defined as having elevated levels of triglyceride (TG), total cholesterol, and low-density lipoprotein-cholesterol (LDL-C) or low levels of high-density lipoprotein-cholesterol (HDL-C), is an important risk factor for CVD and CKD (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…In Taiwan, according to 2005–2008 data, the prevalence of being overweight and obese among adults was 44.1% and was significantly higher than that in Japan, South Korea, and other neighboring Asian countries ( 6 , 7 ). Obesity has been reported to be associated with the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and CKD in addition to dyslipidemia ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study

et al. 2022

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Globally, obesity is a major health problem and can markedly increase the risk of various diseases, including type 2 diabetes mellitus, hypertension (HTN), dyslipidemia, and chronic kidney disease (CKD). The association of obesity-related parameters, such as lipid parameters and their ratio, with CKD in clinical settings is not well understood. This study aimed to investigate the association of obesity-related parameters with CKD in the middle-aged and elderly population in Taiwan. This cross-sectional, community-based study recruited 400 participants (141 males and 259 females) aged 50 years or over from a community health promotion project at the Linkou Chang Gung Memorial Hospital (Guishan District, Taoyuan City) in 2014. Each participant completed a questionnaire including personal information and medical history during a face-to-face interview. Laboratory data were obtained from blood and urine sampling. The data were analyzed using t-test, chi-square test, Pearson's correlation test, multivariate logistic regression, and receiver operating characteristic (ROC) analysis. A total of 81 participants were identified as having CKD [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 or urine albumin/creatinine ratio ≥30 mg/g], and their mean triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio was 3.37 ± 2.72. The mean TG/HDL-C ratio of the 319 participants without CKD was 2.35 ± 1.66. After adjusting for age, TG/HDL-C was significantly positively correlated with blood pressure, body mass index, waist circumference, and fasting plasma glucose but not low-density lipoprotein cholesterol. There was a negative correlation between TG/HDL-C and eGFR. Multiple logistic regression model analysis showed that TG/HDL-C was still significantly associated with CKD (OR: 1.17, 95% CI: 1.01–1.36, p = 0.04) after adjusting for multiple covariates. The cut-off point of TG/HDL-C as a predictor of CKD was 2.54 with an area under the ROC curve of 0.61 (95% CI: 0.53–0.68). There was a significant positive correlation between TG/HDL-C and several cardiovascular disease risk factors, including obesity indices. The TG/HDL-C ratio was significantly associated with the risk of CKD and demonstrated predictive ability for CKD in the middle-aged and elderly population. Further studies on its application in clinical settings are warranted.

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“…The TG/HDL-C ratio responds rapidly to metabolism changes and is a sensitive indicator of the coronary heart condition. 17 …”

Section: Discussionmentioning

confidence: 99%

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Wang¹,

Hua²,

2022

Pak J Med Sci

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Objectives: We assessed the TG/HDL-C ratio as a predictor for the presence of coronary artery calcifications (CACs). Methods: We collected demographic characteristics (age and gender), physical examination (height, weight, BMI, SBP, DBP), comorbidities, medication use, and laboratory variables Triglyceride to High-Density Lipoprotein (TG, HDL-C, TG/HDL-C, UA, TBG, 25-OH-VitD3); and we used coronary angiography to determine the presence of CACs. We performed univariate and multivariate analyses to evaluate the correlation between the TG/HDL-C ratio and CACs and established a predictive model. Results: CAC was present in 121 patients (25.80%). The levels of TG and TG/HDL-C ratio in the CAC group were higher than those in the non-CAC group, while the level of HDL-C in the CAC group was lower than that in the non-CAC group. The univariate analysis showed that the TG/HDL-C ratio was associated with CAC (OR, 0.021; 95% CI, 0.008 to 0.052; P<0.001), and the multivariate analysis indicated that the ratio was an independent risk factor for CAC (OR, 4.088; 95% CI, 2.787-5.996; P<0.001). Using the ratio to establish a prediction model, the area under the ROC curve was 0.814 (95% CI, 0.775-0.853; P<0.001), suggesting that the TG/HDL-C ratio has a high diagnostic efficiency. The diagnostic threshold was 1.037, and the corresponding sensitivity and specificity were 89.3% and 60.5%, respectively. Conclusion: The Triglyceride to High-Density Lipoprotein TG/HDL-C ratio is an independent risk factor for CAC with good diagnostic efficacy. Abbreviations: TG: Triglycerides, HDL-C: High-Density Lipoprotein, CAC: Coronary Artery Calcifications, BMI: Body Mass Index, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, UA: Uric Acid, FBG: Fasting Blood Glucose, 25-OH-VitD3: 25-Hydroxyvitamin D3, ACEI: Angiotensin-Converting Enzyme Inhibitors, ARB: Angiotensin Receptor Blockers, CCB: Calcium Channel Blockers, ARNI: Angiotensin Receptor-Neprilysin Inhibitor, CAG: Coronary Angiography, AUCROC: Area Under the Receiver Operating Curve. doi: https://doi.org/10.12669/pjms.38.3.5290 How to cite this:Wang B, Hua J, Ma L. Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5290 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study

Cited by 12 publications

References 56 publications

Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study

Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study

Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study

Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

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