Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedish population

Derogar, Maryam; Schaaf, M. van der; Lagergren, Pernilla

doi:10.3109/0284186x.2011.614636

Cited by 122 publications

(146 citation statements)

References 15 publications

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“…Based on the QLQ-C30 functional scale, the mean scores for self-reported cognitive (84), emotional (80), and social functioning (87) were lower than reported for role (91) and physical functioning (92). These values are similar to the mean scores reported for a reference population of healthy adults [16] (Table 2). Self-reported symptoms of fatigue, pain and insomnia were the highest mean scores reported on the QLQ-C30 symptom subscale or item.…”

Section: Resultssupporting

confidence: 88%

“…Comparison of the study results to a reference population of independently functioning healthy adults, showed no significant difference in baseline QOL scores in QLQ-C30 domains except for increased financial burdens [16], which is likely due to expenses related to cancer care. Reports assessing QOL in pediatric patients have demonstrated lower overall QOL in children with CNS tumors compared to their healthy counterparts [9, 18]; however, those patients were either undergoing or within one year of treatment completion, while the majority of the participants in this study were several years post treatment.…”

Section: Discussionmentioning

confidence: 99%

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Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

et al. 2014

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BACKGROUND The purpose of this study was to assess the health-related quality of life (HRQOL) and the impact of treatment on HRQOL in long-term survivors of pediatric low-grade gliomas (LGGs) using an adult instrument. METHODS QOL of 121 patients with a diagnosis of LGG from the Mayo Clinic were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30 for cancer in general) and (EORTC QLQ-BN20 specific for brain tumors). RESULTS Median follow-up was 21.9 years for the participants. Median age at diagnosis was 11.8 years and at assessment was 33 years. Mean (standard deviation) global QOL score for the study was 78 (18) and 76.4 (22.8) in a reference population of healthy adults. Using QLQ-C30, radiation treated patients compared to non-radiation patients reported lower physical functioning (p=0.002), role functioning (p=0.004), and more constipation problems (p<0.001). Patients with tumor recurrence reported lower role functioning (p=0.016), social functioning (p=0.040), and more financial problems (p=0.029) compared to their counterparts. Using QLQ-BN20, patients with deep tumors compared to cortical tumors reported more bladder control problems (p=0.016). Radiation treated patients also reported more bladder control problems (p<0.001) compared to their counterparts. In the multivariable analysis, radiation therapy remained an independent predictor of physical and role functioning as well as symptoms related to brain tumors like visual disorders and motor dysfunction. CONCLUSION Global QOL of long-term survivors of pediatric LGGs is similar to that of a reference population of healthy adults. The following tumor and treatment related factors were most consistently associated with poorer QOL: CNS tumor location, post-operative radiation, and tumor recurrence. Future studies are necessary to identify strategies to improve QOL in this subgroup of patients.

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Section: Resultssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

et al. 2014

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“…The values were then in the range of a normal age-standardized Swedish female population. 19 Increased frequency of diarrhea and other intestinal problems as well as urinary frequency were the only exceptions and were recorded as significant remaining adverse effects at 12 months after the external pelvic radiotherapy. No significant adverse effects different from the normal population were noted in the group receiving vaginal brachytherapy alone.…”

Section: Discussionmentioning

confidence: 97%

External Pelvic and Vaginal Irradiation Versus Vaginal Irradiation Alone as Postoperative Therapy in Medium-Risk Endometrial Carcinoma: A Prospective, Randomized Study—Quality-of-Life Analysis

Sorbe

Horváth

Andersson

et al. 2012

Int J Gynecol Cancer

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Despite a significant locoregional control benefit with combined radiotherapy, no survival improvement was recorded; but increased late toxicity from the intestine and the bladder. External beam irradiation decreased global health status during and after treatment, and 3 functional scale items (physical, role, and social). Six of 11 symptom items showed a pattern favoring vaginal brachytherapy alone.

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“…As with chronic pain, the prevalence rates of disabling pain depend on the instruments used. In the German 2012 survey of our study group [14], 7.7% of the general population met the criterion of disabling pain, as defined by the regional pain scale [28] and by a quality of life questionnaire of the European Organisation for Research and Treatment of Cancer QLQ-C30 Version 3.0 [30]. In the Canadian surveys the percentages of persons with disabling pain defined by any limitation of activities by pain or discomfort ranged from 11.4% to 13.3% [27].…”

Section: Discussionmentioning

confidence: 99%

Untying chronic pain: prevalence and societal burden of chronic pain stages in the general population - a cross-sectional survey

et al. 2014

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BackgroundChronic pain is a major public health problem. The impact of stages of chronic pain adjusted for disease load on societal burden has not been assessed in population surveys.MethodsA cross-sectional survey with 4360 people aged ≥ 14 years representative of the German population was conducted. Measures obtained included demographic variables, presence of chronic pain (based on the definition of the International Association for the Study of Pain), chronic pain stages (by chronic pain grade questionnaire), disease load (by self-reported comorbidity questionnaire) and societal burden (by self-reported number of doctor visits, nights spent in hospital and days of sick leave/disability in the previous 12 months, and by current unemployment). Associations between chronic pain stages with societal burden, adjusted for demographic variables and disease load, were tested by Poisson and logistic regression analyses.Results2508 responses were received. 19.4% (95% CI 16.8% to 22.0%) of participants met the criteria of chronic non-disabling non-malignant pain. 7.4% (95% CI 5.0% to 9.9%) met criteria for chronic disabling non-malignant pain. Compared with no chronic pain, the rate ratio (RR) of days with sick leave/disability was 1.6 for non-disabling pain and 6.4 for disabling pain. After adjusting for age and disease load, the RRs increased to 1.8 and 6.8. The RR of doctor visits was 2.5 for non-disabling pain and 4.5 for disabling pain if compared with no chronic pain. After adjusting for age and disease load, the RR fell to 1.7 and 2.6. The RR of days in hospital was 2.7 for non-disabling pain and 11.7 for disabling pain if compared with no chronic pain. After adjusting for age and disease load, the RR fell to 1.5 and 4.0. Unemployment was predicted by lower educational level (Odds Ratio OR 3.27 [95% CI 1.70-6.29]), disabling pain (OR 3.30 [95% CI 1.76-6.21]) and disease load (OR 1.70 [95% CI 1.41-2.05]).ConclusionChronic pain stages, but also disease load and societal inequalities contributed to societal burden. Pain measurements in epidemiology research of chronic pain should include chronic pain grades and disease load.

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Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedish population

Abstract: The reference values provided can be used as a surrogate baseline measure in HRQL research, and when evaluating the effect of interventions on HRQL in cancer patients.

Cited by 122 publications

References 15 publications

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

External Pelvic and Vaginal Irradiation Versus Vaginal Irradiation Alone as Postoperative Therapy in Medium-Risk Endometrial Carcinoma: A Prospective, Randomized Study—Quality-of-Life Analysis

Untying chronic pain: prevalence and societal burden of chronic pain stages in the general population - a cross-sectional survey

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