Reference values for spirometry in elderly individuals: a cross-sectional study of different reference equations

Belo, Joana; Palmeiro, Teresa; Caires, Iolanda; Papoila, Ana Luísa; Alves, Marta; Carreiro‐Martins, Pedro; Botelho, Maria Amália; Neuparth, Nuno

doi:10.1186/s40248-017-0112-5

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…Reference equations should be validated for each population as each population will have different characteristics [ 5 , 17 , 18 ]. The objective when producing the GLI model was to create specific spirometry reference values for different parts of the world.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

et al. 2023

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Background Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects. Methods The study population consisted of 285 healthy adults (148 males, 52%) between 20–90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model. Results No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV1 (forced expiratory volume) and FVC (forced vital capacity), and consequently fewer subjects below the lower limit of normality, than both the rederived LMS and OLIN models. Conclusions Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model based on a larger cohort of Swedish citizens than was available in this study.

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Section: Discussionmentioning

confidence: 99%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

et al. 2023

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“…Reference equations should be validated for each population as each population will have different characteristics [6,18,19]. The objective when producing the GLI model was to create specific spirometry reference values for different parts of the world.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Erelund

Karp

Arvidsson

et al. 2022

Preprint

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Background Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function, stressing the importance of selecting consistant and reliable clinical reference data. This study aims to evaluate the results of lung function testing in subjects without known heart or pulmonary disease living in Northern Sweden, with a focus on a comparison with previously published reference materials. Methods The study is based on 285 (148 males) healthy adults, 20-90 years of age. The subjects had been randomly selected and included in a study of cardiac function in heart-healthy subjects and were also assessed with dynamic spirometry, where 16 subjects presented with pulmonary functional impairments and were excluded. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations are derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. A comparison was made with the reference values given by the original LMS model that is suggested by the Global Lung Initiative (GLI), and with the reference values from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, which is also based on subjects from Northern Sweden. Results No differences were found in the age-dependency of pulmonary function between the new LMS model and the OLIN model. The original GLI reference values suggested significantly lower normal values, and consequently resulted in fewer subjects with both FEV1 and FVC values below the lower limit of normality, than both the new model and the OLIN model. Conclusions Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model with values that are specific for Swedish citizens. For optimal accuracy the final coefficients should be verified in a larger cohort.

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“…The study followed the ATS criteria and spirometry was done by qualified and certified technicians. [21] Haynes assessed the ability to perform spirometry among elderly persons in a hospital in New Hampshire, England. The study reported that 94.6% of the elderly performed acceptable spirometry by ATS/ERS criteria.…”

Section: Discussionmentioning

confidence: 99%

Quality of spirometry testing in a community setting: A study among elderly persons in a rural area of Haryana

Kaur

Kumar

Hadda

et al. 2019

J Family Med Prim Care

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Introduction:Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Early diagnosis and management of COPD require good quality spirometry testing, which is currently not available at primary care level in India. This study reports the quality of spirometry testing at the community level among elderly persons in a rural area.Materials and Methods:A community-based cross-sectional study was conducted among 449 elderly persons in a rural area of Ballabgarh block of Haryana state by a trained investigator. A portable spirometer (MIR Spirolab®) was used. House-to-house visits were undertaken. A self-developed pretested semistructured interview schedule was administrated and spirometry was done according to the American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines.Results:Acceptable quality of spirometry tests was found among 87.3% (95% CI: 84.2%–90.4%) participants. Poor quality of spirometry was associated with low Body Mass Index (BMI) (aOR = 0.49, 95% CI = 0.26–0.93) and age ≥ 70 years (aOR = 0.45, 95% CI = 0.21–0.94) in multivariable analysis.Conclusion:Acceptable quality of spirometry can be performed in community settings by using a portable spirometer.

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Reference values for spirometry in elderly individuals: a cross-sectional study of different reference equations

Cited by 12 publications

References 31 publications

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Quality of spirometry testing in a community setting: A study among elderly persons in a rural area of Haryana

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