Reference values for salivary testosterone in adolescent boys and girls determined using Isotope-Dilution Liquid-Chromatography Tandem Mass Spectrometry (ID-LC–MS/MS)

Büttler, Rahel M.; Peper, Jiska S.; Crone, Eveline A.; Lentjes, Eef G.W.M.; Blankenstein, Marinus A.; Heijboer, Annemieke C.

doi:10.1016/j.cca.2016.02.015

Cited by 22 publications

(29 citation statements)

References 18 publications

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“…The mean age was used in situations in which girls reported 2 ages of menarche in the 12- and 14-year surveys (n = 30, mean reported difference0.15 ± 0.8 years SD). Testosterone levels, which increase as puberty progresses, 33 were used to corroborate self-assessed Tanner stages at a group level. Saliva samples were obtained as previously described.…”

Section: Methodsmentioning

confidence: 99%

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Johnson

Tang

Almas

et al. 2018

The Journal of Pediatrics

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Objectives To determine the effects of foster care vs institutional care, as well as disruptions in the caregiving environment on physical development through early adolescence. Study design This was a randomized controlled trial of 114 institutionalized, though otherwise healthy, children from 6 orphanages and 51 never institutionalized control children living in birth families (family care group) in Bucharest, Romania. Children were followed from baseline (21 months, range 5–31) through age 12 years for caregiving disruptions and growth trajectories and through age 14 years for pubertal development. Results Children randomized to the foster care group showed greater rates of growth in height, weight, and body mass index (BMI) through age 12 years than institutionalized group. Tanner development was delayed in institutionalized group boys compared with foster care group and family care group boys at 12 but not 14 years. There were no differences in Tanner development and age of menarche among foster care group, institutionalized group, and family care group girls at ages 12 and 14 years. More disruptions in caregiving between 30 months and 12 years moderated decreases in growth rates of height in foster care group and weight in foster care group and institutionalized group across age. institutionalized group boys with ≥2 disruptions showed lower Tanner scores at age 12 vs institutionalized group and foster care group boys with <2 disruptions. foster care group girls with ≥2 disruptions had higher Tanner scores at age 14 vs foster care group girls with <2 disruptions. Age of menarche was not affected by caregiving disruptions. Conclusions For children who experienced early institutionalization, stable placement within family care is essential to ensuring the best outcomes for physical developmental. Trial registration clinicaltrials.gov: NCT00747396.

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Section: Methodsmentioning

confidence: 99%

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Johnson

Tang

Almas

et al. 2018

The Journal of Pediatrics

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“…It is also important to note that low testosterone and estradiol concentrations in pre- and early pubertal levels in girls and boys may be difficult to detect as they may fall below detection level using radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) methods (Ankarberg and Norjavaara 1999). However, a more recent liquid chromatography-mass spectrometry (LC-MS) technique (Herold and Fitzgerald 2003, Albrecht and Styne 2007) may be more reliable and able to capture low concentration in pre- and early pubertal levels in girls and boys (Buttler, Peper et al 2016). …”

Section: Pubertymentioning

confidence: 99%

Puberty and structural brain development in humans

Herting

Sowell

2017

Frontiers in Neuroendocrinology

226

183

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Adolescence is a transitional period of physical and behavioral development between childhood and adulthood. Puberty is a distinct period of sexual maturation that occurs during adolescence. Since the advent of magnetic resonance imaging (MRI), human studies have largely examined neurodevelopment in the context of age. A breadth of animal findings suggest that sex hormones continue to influence the brain beyond the prenatal period, with both organizational and activational effects occurring during puberty. Given the animal evidence, human MRI research has also set out to determine how puberty may influence otherwise known patterns of age-related neurodevelopment. Here we review structural-based MRI studies and show that pubertal maturation is a key variable to consider in elucidating sex- and individual-based differences in patterns of human brain development. We also highlight the continuing challenges faced, as well as future considerations, for this vital avenue of research.

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“…Samples can easily be collected by passive drool or simple saliva collection tools without any medical assistance or help. Recent studies indicate interference of saliva collection devices on hormone measurements, suggesting that the most reliable technique is a simple drooling into polypropylene tubes …”

Section: Introductionmentioning

confidence: 99%

“…Recent studies indicate interference of saliva collection devices on hormone measurements, suggesting that the most reliable technique is a simple drooling into polypropylene tubes. [13][14][15] The concentrations of salivary hormones are within picomolar ranges, in both males and females; hence, a very sensitive and accurate quantification method is needed. Thus, we established a liquid chromatography-tandem mass spectrometry (LC-MS/ MS)-based approach for the simultaneous quantification of salivary testosterone and androstenedione in a well-characterized cohort of patients with PCOS and healthy women and further examined their association with parameters of metabolic health.…”

Section: Introductionmentioning

confidence: 99%

High salivary testosterone‐to‐androstenedione ratio and adverse metabolic phenotypes in women with polycystic ovary syndrome

Münzker

Lindheim

Adaway

et al. 2017

Clinical Endocrinology

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Reference values for salivary testosterone in adolescent boys and girls determined using Isotope-Dilution Liquid-Chromatography Tandem Mass Spectrometry (ID-LC–MS/MS)

Cited by 22 publications

References 18 publications

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Puberty and structural brain development in humans

High salivary testosterone‐to‐androstenedione ratio and adverse metabolic phenotypes in women with polycystic ovary syndrome

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