Reference values for reticulocyte parameters and hypochromic RBC in healthy children

Abstract

Establishing reliable pediatric reference intervals for these novel hematological parameters may offer valuable prospects for clinical practice and research in the pediatrics field.

Reference intervals for reticulocyte hemoglobin content in healthy infants

“…The study also included approximately 30% preterm (less than 37 weeks gestational age) infants. The mean Ret-He at birth was 35.9 pg/L (3.1), which is higher than in the present study, 31. years, which might explain this discrepancy (19).…”

“…The potential clinical utility of Ret-He for diagnosis of iron deficiency in infancy has so far been limited by the lack of reference intervals (9, 16), but has been proposed to be superior to ferritin and transferrin saturation in the evaluation of iron status in anemic children in chronic dialysis (17). Reference intervals have been reported for newborns within 24 h, in a population of children between 6 months and 5 years, with a median of 4 years, and for infants during their fist 90 days (18)(19)(20)(21). A recent study compared Ret-He and soluble transferrin receptors (sTfR) for the diagnosis of iron depletion in young children aged 0.5-3 years, comparing these biomarkers with ferritin levels (22).…”

Measurement of iron status in chronic kidney disease

“…Pediatric reference ranges for CHr and Ret-He have been established [48, 49]. There is now sufficient evidence for the clinical utility of CHr and Ret-He that their use is recommended for the assessment of iron status in patients with CKD in European best practice guidelines [50] and UK NICE guidelines on the anemia in CKD [23].…”

Renale Anämie bei Kindern

“…B. bei entzündlichen Erkrankungen, aber auch in Gegenwart diverser anderer schwerer Erkrankungen, so stark gestört, dass eine klinische Interpretation der Messergebnisse unter diesen Umständen schwierig oder unmöglich ist [13,17]. [11,[19][20][21].…”