Reference values for paediatric pulmonary function testing: The Utrecht dataset

Koopman, Marije; Zanen, Pieter; Kruitwagen, Cas; Ent, Cornelis K. van der; Arets, Hubertus G.M.

doi:10.1016/j.rmed.2010.07.020

Cited by 100 publications

(103 citation statements)

References 30 publications

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“…In addition, participants in the school children age group showed a significantly higher success rate in manovacuometry and spirometry tests, compared to the preschool children group. Such findings support previous studies showing a greater ease in the performance of pulmonary function tests in school age, since the higher the age of the individual the greater its ability for interpretation, concentration, and motor skills for the performance of the tests 5,6,9 . Thus, these methods for pulmonary assessment can be characterized as simple tests, of easy understanding and clinical applicability, enabling the measurement of respiratory capacity, volumes, and flows, as well as respiratory muscle strength in young age group 1,25,26 .…”

Section: Discussionsupporting

confidence: 91%

“…These methods are important tools not only as clinical parameters at the time of evaluation, but also as objective instruments for the long-term monitoring of lung growth from childhood to adulthood 4,5 . In clinical practice, they are commonly used in subjects with a predisposition to the development of respiratory disorders, neuromuscular disorders, and in patients with lung diseases, such as asthma and cystic fibrosis 3,6 . Among the pulmonary function tests, spirometry is characterized as one of the most widely used methods of pulmonary assessment in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Frequência de sucesso de pré-escolares e escolares com e sem sintomas respiratórios nos testes de função pulmonar

et al. 2016

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| The aim of this study was to evaluate the success rate of preschool and school children with/without respiratory symptoms in pulmonary function tests. Children and adolescents, aged 4 to 12 years, with/without respiratory symptoms based on the questionnaire of respiratory diseases were included. Participants were recruited from two schools and classified according to their age group in preschool children (4-6 years) and school children (7-12 years). We collected demographic and anthropometric data, and the variables of the manovacuometry test (MIP and MEP) and spirometry test (FEV1, FVC, FEV1/FVC, and FEF25-75%).Pulmonary function tests were considered successful when the participants reached acceptability and reproducibility criteria established by national and international guidelines.In the statistical analysis, we used the chi-square test and Pearson correlation test. We included 148 participants, mean age of 8.1±1.7 years, being 51.4% female and 85.1% healthy. The success rate for the manovacuometry test and spirometry was 91.9% and 91.2%, respectively. There was a significantly lower success rate in the preschool group, compared to school children for both manovacuometry (p=0.044) and spirometry (p=0.015) tests. We found positive correlations between the MIP and FEV1 and MEP and FEF25-75%. The findings demonstrated a significantly lower success rate in 1 93 preschool age group, compared to pre-school subjects in both pulmonary function tests evaluated..

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Frequência de sucesso de pré-escolares e escolares com e sem sintomas respiratórios nos testes de função pulmonar

et al. 2016

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“…Tests would be considered valid when at least 3 acceptable and reproducible maneuvers were obtained, with a variation of Ͻ5%. Data were expressed in absolute values and in percentage of the predicted, using the equations of Koopman et al 22 Lung function was performed using a flux-based spirometer (KoKo, Louisville, Colorado). Spirometric parameters evaluated included FEV 1 , FVC, and forced expiratory flow between 25 and 75% of vital capacity.…”

Section: What This Paper Contributes To Our Knowledgementioning

confidence: 99%

Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis

et al. 2015

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BACKGROUND: Pulmonary changes that occur in cystic fibrosis may influence inspiratory muscle strength and endurance. We evaluated inspiratory muscle strength and endurance in children and adolescents with cystic fibrosis in comparison with healthy subjects. METHODS: This is a crosssectional observational study with subjects with cystic fibrosis and paired healthy individuals, age 6 -18 y. Spirometry, impulse oscillometry, plethysmography, manovacuometry, and a protocol of inspiratory muscle endurance were performed. RESULTS: Subjects with cystic fibrosis (n ‫؍‬ 34) had higher maximum percent-of-predicted inspiratory pressure (P Imax ) than healthy (n ‫؍‬ 68) subjects (118.5 ؎ 25.8% vs 105.8 ؎ 18.0%) and no significant difference in endurance (60.9 ؎ 13.3% vs 65.3 ؎ 12.3%). When restricting the analysis to subjects without Pseudomonas aeruginosa colonization and with FEV 1 > 80%, P Imax values were significantly higher, and inspiratory muscle endurance was lower, in comparison with the control group. P Imax correlated significantly with FVC (r ‫؍‬ 0.44, P ‫؍‬ .02) and FEV 1 (r ‫؍‬ 0.41, P ‫؍‬ .02), whereas endurance correlated better with total airway resistance (r ‫؍‬ 0.35, P ‫؍‬ .045) and with central airway resistance (r ‫؍‬ 0.48, P ‫؍‬ .004). CONCLUSIONS: Children and adolescents with cystic fibrosis with no colonization by P. aeruginosa and normal lung function present increased inspiratory muscle strength and decreased endurance compared with healthy individuals, indicating that changes in the respiratory muscle function seem to be distinctly associated with pulmonary involvement. Strength was related to pulmonary function parameters, whereas endurance was associated with airway resistance.

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“…23 Stanojevic et al 24 reference equations were used for spirometric parameters. Koopman et al 25 reference equations were used for D LCO and D LCO /V A and extrapolated to ages above 18 years to avoid an artificial variance between age groups arisen from differences between reference materials. All reference equations for pulmonary function parameters were gender, age and height specific.…”

Section: Examinationsmentioning

confidence: 99%

Aerobic exercise capacity at long-term follow-up after paediatric allogeneic haematopoietic SCT

Mathiesen

Uhlving

Buchvald

et al. 2014

Bone Marrow Transplant

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Peak oxygen uptake (VO 2peak ), a measure of aerobic exercise capacity, predicts mortality and morbidity in healthy and diseased individuals. Our aim was to determine VO 2peak years after paediatric allogeneic haematopoietic SCT (HSCT) and to identify associations with baseline patient and donor characteristics, transplantation factors, pulmonary function and self-reported sports activity. In this cross-sectional, population-based study, we measured VO 2peak , spirometry and diffusion capacity of the lung (D LCO ) 3-10 years post HSCT. Z-scores were calculated by reference values from healthy subjects. Self-reported hours of sports activity were obtained by interview. We included 63 patients (mean age (range) 14.4 (7-24) years). HSCT patients exhibited lower mean VO 2peak (−1.42 z-score, 95% confidential interval (−1.7; − 1.1)) compared with healthy subjects (Po 0.001). Sixteen patients (25%) had VO 2peak values o − 1.96 z-score. Low VO 2peak was associated with reduced forced expiratory volume in 1 s (R 2 = 0.11, P = 0.009), reduced D LCO /V A (R 2 = 0.09, P = 0.01) and low physical activity (mean VO 2peak z-score inactive group: − 2.1 vs most active group: − 1.1, P = 0.02). No associations between VO 2peak and diagnosis, donor type or GvHD were found. Although causes for reduced VO 2peak may be multiple, our findings stress the need to focus on physical activity post HSCT to prevent lifestyle diseases and improve quality of life. INTRODUCTIONThe population of long-term survivors after allogeneic haematopoietic SCT (HSCT) has increased owing to advances in donor selection and improvements in conditioning regimens and supportive care. Improved survival has increased the focus on late effects and quality of life. 1 HSCT may affect multiple organ systems as a result of the toxicity from chemotherapy, TBI and complications including GvHD and infections. 1 In a recent retrospective study, we documented reduced spirometric values in 34% of paediatric patients more than 18 months from HSCT. 2 However, little is known about the potential consequences of reduced pulmonary function for daily life activities and aerobic exercise capacity.Peak oxygen uptake (VO 2peak ) is a measure of physical capacity, which integrates the responses of the cardiovascular, pulmonary and musculoskeletal systems when faced with physical requirements; 3 thus, VO 2peak allows evaluation of abnormalities, which may not be apparent during rest. 4 As a measure of cardiorespiratory fitness, VO 2peak is a powerful predictor of morbidity and mortality in both healthy and diseased individuals. 5,6 In cancer patients, reduced VO 2peak has been associated with fatigue, which is known to reduce the quality of life, especially in children and young adults for whom physical activities are an essential part of the daily routine. 7 A recent systematic review revealed slightly reduced VO 2peak in survivors of childhood leukaemia compared with healthy controls. 8 Although HSCT has been described as the treatmentvariable most consistently associated with redu...

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Reference values for paediatric pulmonary function testing: The Utrecht dataset

Abstract: These new paediatric reference equations provide accurate estimates of the range of normality for most commonly used pulmonary function indices, resulting in less underdiagnosis and overdiagnosis of pulmonary diseases.

Cited by 100 publications

References 30 publications

Frequência de sucesso de pré-escolares e escolares com e sem sintomas respiratórios nos testes de função pulmonar

Frequência de sucesso de pré-escolares e escolares com e sem sintomas respiratórios nos testes de função pulmonar

Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis

Aerobic exercise capacity at long-term follow-up after paediatric allogeneic haematopoietic SCT

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