Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan

Ohashi, Fumiko; Fukui, Yoshinari; Takada, Shiro; Moriguchi, Jiro; Ezaki, Takafumi; Ikeda, Masayuki

doi:10.1007/s00420-006-0109-4

Cited by 49 publications

(32 citation statements)

References 44 publications

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“…Differences of gender in food intake, iron status, and hormonal influences could affect the absorption and bioavailability of metals 8 . Multivariate analysis showed age-dependent increases in urinary levels of heavy metals, thus supporting the findings of previous studies 13 . Levels of education and income per month were used as an indicators of socioeconomic status, which may potentially confound the urinary level of metals since they have been associated with differences in dietary patterns, lifestyle, and occupational exposure, and these factors in turn influence the level of exposure to environmental pollutants 14 .…”

Section: Discussionsupporting

confidence: 89%

RETRACTED ARTICLE: Assessment of human biomonitoring and DNA microarray analysis in the vicinity population on an industrial complex

Lee

Chung

Moon

et al. 2011

Mol. Cell. Toxicol.

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The purpose of this study was to assess current exposure of the population living in the Gwangyang industrial complex and other areas to heavy metals and, VOCs and to identify individual factors associated with urinary and blood levels of these chemicals. The study population was made up of 810 participants ranging in age from 7 to 87 years old at Gwangyang bay in the South Korea. The selected biomarkers represent the main agents to which a population like that of Korean is exposed every day, including 4 heavy metals in blood or urine (Pb in blood and As, Cd, Hg in urine), and VOCs in blood descriptive data analysis leads to mean concentrations of heavy metals, As, Cd, Hg and Pb of 7.34 μg/g cr, 1.04 g/g cr, 1.33 μg/g cr and 2.53 μg/dL, respectively. The mean concentration of benzene, ethylbenzene, tetrachloroehylene, toluene, m-/p-xylene and o-xylene in blood were 0.00 μg/ L, 0.00 μg/L, 0.00 μg/L, 0.03 μg/L,0.00 μg/L and 0.00 μg/L, respectively. The DNA microarray analysis using blood of 16 participants, control group (n=6) and sample group (n=10), showed that the two groups might belong to a different group through hierarchical clustering the present study provides reference values for selected pollutants for the general population in industrial complexes, which can be used for comparison purposes in further studies, since they are mostly within the reference ranges reported by other biomonitoring studies therefore, it would be possible to devise standards for identifying the environmental pollution and beforehand forecast. In addition, it will be the one of the scientific method to help reduce anxiety of residents lived in the polluted areas.

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Section: Discussionsupporting

confidence: 89%

RETRACTED ARTICLE: Assessment of human biomonitoring and DNA microarray analysis in the vicinity population on an industrial complex

Lee

Chung

Moon

et al. 2011

Mol. Cell. Toxicol.

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“…In particular, we found a significant inverse correlation between urinary concentration of Cr, Co, Rb, and Sn and age, while a direct relationship between age and Ga. While the finding related to Cr, Rb and Sn are in agreement to those reported previously (CDC, 2009;Heitland and Köster, 2006), the result found for Co is not supported by other studies performed on children and adult population (Heitland and Köster, 2006;Moreno et al, 2010;Ohashi et al, 2006). Thus, it is presumable that the urinary levels of Cr, Rb and Sn were affected by the greater susceptibility to environmental pollution of younger children, also evidenced for other chemicals (Wild and Kleinjans, 2003), while the urinary concentrations of Co were more influenced by behavioral variables related to age (such as hand to mouth habits, physical activity, etc), rather than age itself (Moreno et al, 2010).…”

Section: Discussionsupporting

confidence: 74%

Urinary levels of trace elements among primary school-aged children from Italy: The contribution of smoking habits of family members

Protano¹,

Astolfi

Canepari

et al. 2016

Science of The Total Environment

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“…After reviewing monitoring data in occupationally exposed workers, Ohashi et al (2006) determined reference values for Ni in urine among women of the general population of 11 prefectures in Japan. The observed geometric mean for urinary Ni was 2.1 μg/L (range, < 0.2-57 μg/L) corresponding to 1.8 μg/L (maximum, 144 μg/L) after normalization by creatinine excretion.…”

Section: Biomonitoringmentioning

confidence: 99%

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Publication¹

2015

EFS2

118

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EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) decided to extend the risk assessment also to drinking water. The reproductive and developmental toxicity in experimental animals was selected as the critical effect for the assessment of chronic effects of Ni. A tolerable daily intake of 2.8 µg Ni/kg body weight (b.w.) per day was derived from a lower 95 % confidence limit for a benchmark dose at 10 % extra risk (BMDL 10 ) of 0.28 mg/kg b.w. for post-implantation fetal loss in rats. The current dietary exposure to Ni raises concern when considering the mean and 95th percentile chronic exposure levels for all different age groups. The systemic contact dermatitis (SCD) elicited in Ni-sensitive humans after oral exposure to Ni was selected as the critical effect suitable for the assessment of acute effects of Ni. A lowest BMDL 10 of 1.1 µg Ni/kg b.w. was derived for the incidence of SCD following oral exposure to Ni of human volunteers. The CONTAM Panel applied a margin of exposure (MOE) approach and considered an MOE of 10 to be indicative of a low health concern. The MOEs calculated considering the estimated mean and the 95th percentile acute exposure levels were considerably below 10 for all age groups. Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Ni-sensitized individuals may develop eczematous flare-up skin reactions. The CONTAM Panel noted the need for mechanistic studies to assess the human relevance of the effects on reproduction and development observed in experimental animals and for additional studies on human absorption of nickel from food, for example in combination with duplicate diet studies. Following a call for data on Ni levels in food and drinking water (water intended for human consumption and mineral waters), a total of 18 885 food samples and 25 700 drinking water samples were available in the final dataset to estimate dietary exposure to nickel. No speciation data were provided. Samples were collected between 2003 and 2012 in 15 different European countries, with almost 80 % of the total collected in one Member State. The most reported analytical methods were inductively coupled plasma-mass spectrometry (ICP-MS) and atomic absorption spectrometry (AAS), that represented 54 % and 42 % of the methods reported, respectively. The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery'. In the final dataset, left-censored data represented 66 % of the analytical results, with 35 % in food samples and 89 % in drinking water sa...

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Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan

Abstract: Comparison with values reported in literatures for other areas showed that Co and Ni levels in urine of Japanese women are higher than, Cu level is comparable with, and Mn level is lower than others. The reasons for high Co and Ni levels deserve further study.

Cited by 49 publications

References 44 publications

RETRACTED ARTICLE: Assessment of human biomonitoring and DNA microarray analysis in the vicinity population on an industrial complex

RETRACTED ARTICLE: Assessment of human biomonitoring and DNA microarray analysis in the vicinity population on an industrial complex

Urinary levels of trace elements among primary school-aged children from Italy: The contribution of smoking habits of family members

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

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