Reference Typing Report for Complement Receptor 1 (CR1)

Abstract

A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e.g. CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55–0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.

Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1

“…A single donor previously studied as part of the VIIth International Complement Genetics Workshop was used for the standard. 21 …”

CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand.

“…For example, although renal failure is a common manifestation of severe falciparum malaria in adults, this is very rare in children, 30 and immune complexes are thought to play a role in renal lesions caused by falciparum malaria infection. 31 It is paradoxical that the L allele is relatively frequent in the Thai population (Thai 0.52, Chinese 0.28, 32 Hungarian 0.21, 14 and British 0.27), 33 despite its association with increased susceptibility to the severe form of malaria. This allele frequency was probably selected not only for protection against malaria.…”

CR1 genotype and haplotype involvement in coronary artery disease: The pivotal role of hypertension and dyslipidemia

“…The alleles are correlated respectively with either a high (H) or low (L) CR1/E ratio (16,18). Erythrocytes from individuals homozygous for the H allele may show as much as a 10-fold higher CR1/E ratio than those from individuals homozygous for the L allele; heterozygous individuals have intermediate CR1 expression (17)(18)(19). Since impaired clearance of ICs could result in increased tissue damage in a variety of inflammatory and infectious conditions (16), we hypothesized that coronary artery disease, a disease characterized by a strong inflammatory condition with a possible infectious trigger, could be characterized by an altered frequency of CR1 gene alleles.…”