Reference Ranges of Lymphocyte Subsets in Healthy Individuals from Southern Iran

Determining reference ranges for immunological cells of healthy indigenous individuals from a region in Brazil

“…( 22 , 32 ) Additionally, our results showed that the relative number of Natural Killer cells was lower in women than in men, which is consistent with previous reports. ( 20 , 31 ) Different levels of sex hormones may underlie the sex differences in lymphocyte subsets, as estrogen levels are higher in women and can block early T cell development in the thymus. ( 33 )…”

“…The CD4+/CD8+ ratio was higher in women than in men, which is consistent with results reported in other countries. (29,(30)(31)(32) Some studies have suggested that the percentage of T lymphocyte subsets is generally low in men, (30,31) while others have found no differences between the sexes. (22,32) Additionally, our results showed that the relative number of Natural Killer cells was lower in women than in men, which is consistent with previous reports.…”

“…(22,32) Additionally, our results showed that the relative number of Natural Killer cells was lower in women than in men, which is consistent with previous reports. (20,31) Different levels of sex hormones may underlie the sex differences in lymphocyte subsets, as estrogen levels are higher in women and can block early T cell development in the thymus. (33) An increase in CD4+CD8+ double-positive (DP) T cells in the peripheral blood has been associated with the risk of plasma leakage in some viral diseases (29) and human urogenital cancers, with conflicting data regarding their role.…”