Reference ranges for the left ventricle modified myocardial performance index, respective time periods, and atrioventricular peak velocities between 20 and 36 + 6 weeks of gestation

Peixoto, Alberto Borges; Bravo-Valenzuela, Nathalie Jeanne; Martins, Wellington P.; Mattar, Rosiane; Moron, Antônio Fernandes; Júnior, Edward Araujo

doi:10.1080/14767058.2019.1609933

Cited by 12 publications

(19 citation statements)

References 46 publications

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“…This study found that neither of them changes with GA, BW, and BSA, which is consistent with the findings of a full-term neonatal heart reference value study (12). This shows that in the postnatal cycle transition period, the LV systolic function of premature infants maintained a relatively stable level, and the median (IQR) was 67 (62-73) and 34 (31)(32)(33)(34)(35)(36)(37)(38), respectively. MV-A is 32).…”

Section: Discussionsupporting

confidence: 88%

Reference Values for Point-of-Care Echocardiographic Measurements of Preterm Infants in China

Tong

Liu

et al. 2022

Front. Pediatr.

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BackgroundFew studies have examined the reference value of the left ventricular structure and function in preterm infants. This study was designed to establish a point-of-care echocardiographic reference range of left ventricular structure and function based on different gestational age, weight, and body surface area (BSA) for preterm infants within 7 days after birth.MethodsWe retrospectively studied 489 patients with traditional echocardiographic data of left ventricular (LV) M-mode: LV end diastolic dimensions (LVED), LV end systolic dimension (LVES), end-diastolic interventricular septal thickness (IVSd), end diastolic LV posterior wall thickness (LVPWd), left atrial (LA) and aortic root (AO) diameters, and index of LA/AO, LV ejection fraction (LVEF), LV fractional shortening (LVFS), and pulsed wave Doppler: aortic valve flow rate (AV), peak mitral valve flow rate E(MV-E), peak mitral valve flow rate A(MV-A), and MV-E/A. The LV dimensions and the maximum blood flow velocities of the aortic valves and mitral valves according to gestational age, birth weight, and body surface area (BSA) are presented in percentiles tables. Percentile curves of aforesaid four cardiac measurements (LVED, LA diameter (LAD), MV-E, MV-E/A) using the R language Generalized Additive Models for Location, Scale and Shape (GAMLSS) method were developed according to different gestational ages and weights.ResultsMeasurements of all cardiac dimensions and Doppler maximum velocities of AV, MV-E, and MV-E/A showed a correlation with gestational age, weight, and BSA. LVED, LAD, MV-E, and MV-E/A showed a trend of increasing values with gestational age and weight on the percentile curves.ConclusionThe percentile tables and graphs of these point-of-care echocardiographic data can provide reliable reference data for Chinese neonates. Normative values are recommended as a source of reference data for the identification of potentially abnormal echocardiography.

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Section: Discussionsupporting

confidence: 88%

Reference Values for Point-of-Care Echocardiographic Measurements of Preterm Infants in China

Tong

Liu

et al. 2022

Front. Pediatr.

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“…The normal reference ranges of fetal LV Mod-MPI by pulsed Doppler were established, and both the crosssectional and longitudinal data demonstrated a linear correlation between GA and Mod-MPI. In fact, not only previously published normal ranges of fetal Mod-MPI exhibit wide variations among studies but also the changes of fetal LV Mod-MPI with advancing weeks of gestation are conflicting [3][4][5][6][7][8][9][10][11][12][13] (table 8). Therefore, it is necessary to provide longitudinal validation of the temporal changes and normal references of fetal LV Mod-MPI to control for confounding factors.…”

Section: Discussionmentioning

confidence: 99%

“…However, the normal reference ranges of fetal Mod-MPI still show wide variation in recent studies. [3][4][5][6][7][8][9][10][11][12][13][14] We have analysed the reasons for this, and they are probably due to a lack of a large enough sample size, a lack of standardised measurement techniques of Mod-MPI, heterogeneous study populations and possibly other maternal or fetal characteristics.…”

Section: Introductionmentioning

confidence: 99%

Reference ranges of fetal heart function using a Modified Myocardial Performance Index: a prospective multicentre, cross-sectional study

Sun

Wang

et al. 2021

BMJ Open

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ObjectivesThe primary aim of this study was to establish the normal reference ranges of the fetal left ventricular (LV) Modified Myocardial Performance Index (Mod-MPI). A secondary aim was to evaluate the agreement between manual and automatic measurements for fetal Mod-MPI.DesignA prospective, multicentre, cross-sectional study.ParticipantsNormal singleton pregnancies.MethodsThe LV functions of normal singleton pregnancies were assessed in nine centres covering eight provinces in China using unified ultrasound protocols and settings and standardised measurements by pulsed Doppler at 20–24, 28–32 and 34–38 weeks of gestation. The isovolumetric relaxation time (IRT), isovolumetric contraction time, ejection time (ET) and Mod-MPI were measured both automatically and manually.ResultsThis cross-sectional study included 2081 fetuses, and there was a linear correlation between gestational age (GA) and Mod-MPI (0.416+0.001×GA (weeks), p<0.001, r2=0.013), IRT (36.201+0.162× GA (weeks), p<0.001, r2=0.021) and ET (171.418–0.078*GA (weeks), p<0.001, r2=0.002). This finding was verified using longitudinal data in a subgroup of 610 women. The agreement between the manual and automated measurements for Mod-MPI was good.ConclusionsWe constructed normal reference values of fetal LV Mod-MPI. Automatic measurement can be considered for ease of measurement in view of the good agreement between the automatic and manual values.

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“…Myocardial dysfunction may lead to prolonged isovolumetric intervals and decreased ET, resulting in increased MPI. MPI values higher than 0.52 were highly sensitive and specific to predict adverse events during pregnancy and the neonatal period (16)(17)(18)(19) .…”

Section: Analysis Of Systolic Functionmentioning

confidence: 99%

Fetal cardiac function by three-dimensional ultrasound using 4D-STIC and VOCAL – an update

et al. 2019

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Three-and four-dimensional (3D/4D) ultrasonography with spatio-temporal image correlation (4D-STIC) allows obtaining fetal cardiac volumes and their static and real-time analysis in multiplanar and rendering modes. Cardiac biometrics and Doppler-echocardiographic parameters for evaluation of fetal heart function, including cardiac output and stroke volume, can be analyzed using M-mode, two-dimensional (2D), and 3D/4D cardiac ultrasound. In recent years, functional echocardiography has been used to study fetuses without a structurally cardiac defect but who are at risk of heart failure due to the presence of extra-cardiac conditions, such as, fetal growth restriction, tumors/masses, twin-to-twin transfusion syndrome, fetal anemia (Rh alloimmunization), congenital infections, or maternal diabetes mellitus. The assessment of cardiac function provides important information on hemodynamic status and can help optimize the best time for delivery and reduce perinatal morbidity and mortality. Since 2003, with the advent of the 4D-STIC software, it is possible to evaluate the fetal heart in multiplanar, and rendering modes. This technology associated with virtual organ computer-aided analysis (VOCAL) enables determining the ventricular volume (end-diastole, end-systole), the stroke-volume, the ejection fraction, and the cardiac output of each ventricle. Since 2004, several studies demonstrated that the 4D-STIC and VOCAL had good reproducibility to measure cardiac volumes This study reviews published studies that evaluated the fetal cardiac function by 3D ultrasound using 4D-STIC and VOCAL software.

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Reference ranges for the left ventricle modified myocardial performance index, respective time periods, and atrioventricular peak velocities between 20 and 36 + 6 weeks of gestation

Cited by 12 publications

References 46 publications

Reference Values for Point-of-Care Echocardiographic Measurements of Preterm Infants in China

Reference Values for Point-of-Care Echocardiographic Measurements of Preterm Infants in China

Reference ranges of fetal heart function using a Modified Myocardial Performance Index: a prospective multicentre, cross-sectional study

Fetal cardiac function by three-dimensional ultrasound using 4D-STIC and VOCAL – an update

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