Reference range of serum haptoglobin is haptoglobin phenotype-dependent in blacks

Immunochemical property of human haptoglobin phenotypes: Determination of plasma haptoglobin using type-matched standards

“…5, in which Hp 2-2 possesses redundant-identical epitopes. Notably, all the immunoturbidimetric and immunonephelometric assays show a differentially higher Hp 1-1 value than 2-1 or 2-2 [13][14][15]19]. The latter data were expected owing to the high immunoreactivity of Hp 1-1 in solution (Fig.…”

“…We have recently described simple procedures, in which each Hp phenotype can be isolated using a monoclonal antibody (mAb) affinity column [11,12]. Limited studies [13][14][15] have indicated that the plasma concentration of Hp 1-1 is differentially higher than that of 2-1 and 2-2, but other reports are varied and inconsistent [16][17][18][19]. In the present study, we hypothesized that the inconsistency of reported Hp values could be due to the differences in surface antigenic structures among Hp 1-1, 2-1, and 2-2.…”

Association of Haptoglobin Levels With Age, Parasite Density, and Haptoglobin Genotype in a Malaria-Endemic Area of Gabon

“…21 Levels of Hp in this study were low compared with Caucasians and Africans without malaria but comparable to those of asymptomatic malaria-infected populations in Africa. 10,[22][23][24] The prevalence of ahaptoglobinemia was low compared to other studies, where prevalences of 20-50% were found. 9,14,21,[25][26][27][28][29][30][31][32][33][34] This discrepancy can be explained by the different methodologies used to define ahaptoglobinemia.…”

Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype

“…The Hp2-2 protein is present in lower concentrations [ 7] and binds less efficiently to free haemoglobin; Hp1-1 and Hp1-2 have higher binding affinities [ 8]. These differences are reflected in vivo by altered oxidant defence and iron handling.…”