Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis

Geel, Nanja van; Vandendriessche, D; Vandersichel, Elise; Schepper, Sofie De; Grine, Lynda; Mertens, Laura; Vandaele, Virginie; Spoelders, F; Bekkenk, Marcel W.; Wolkerstorfer, Albert; Prinsen, Cecilia A.C.; Speeckaert, Reinhart

doi:10.1111/bjd.17190

Cited by 16 publications

(17 citation statements)

References 8 publications

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“…A recent publication introduced a delicate method to generate VASI automatically, through superpixel‐generated computerized digital image analysis of clinical photographs with ImageJ 246 . Another study proposed a protocol for calculating the true depigmentation area which could serve as a “gold standard” for validation of other digital tools 247 . The combination of these two methods might facilitate both vitiligo diagnosis and therapeutic efficacy assessment.…”

Section: Adaptive Immune Activationmentioning

confidence: 99%

Mechanisms of melanocyte death in vitiligo

Chen

2020

Medicinal Research Reviews

149

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Vitiligo is an autoimmune depigment disease results from extensive melanocytes destruction. The destruction of melanocyte is thought to be of multifactorial causation. Genome‐wide associated studies have identified single‐nucleotide polymorphisms in a panel of susceptible loci as risk factors in melanocyte death. But vitiligo onset can't be solely attributed to a susceptive genetic background. Oxidative stress triggered by elevated levels of reactive oxygen species accounts for melanocytic molecular and organelle dysfunction, a minority of melanocyte demise, and melanocyte‐specific antigens exposure. Of note, the self‐responsive immune function directly contributes to the bulk of melanocyte deaths in vitiligo. The aberrantly heightened innate immunity, type‐1‐skewed T helper, and incompetent regulatory T cells tip the balance toward autoreaction and CD8+ cytotoxic T lymphocytes finally execute the killing of melanocytes, possibly alarmed by resident memory T cells. In addition to the well‐established apoptosis and necrosis, we discuss several death modalities like oxeiptosis, ferroptosis, and necroptosis that are probably employed in melanocyte destruction. This review focuses on the various mechanisms of melanocytic death in vitiligo pathogenesis to demonstrate a panorama of that. We hope to provide new insights into vitiligo pathogenesis and treatment strategies by the review.

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Section: Adaptive Immune Activationmentioning

confidence: 99%

Mechanisms of melanocyte death in vitiligo

Chen

2020

Medicinal Research Reviews

149

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“…The primary outcome of our study was percent repigmentation assessed by planimetry, which has been validated for use in vitiligo and alopecia areata. 20 This method despite being accurate and reproducible, is technically demanding and time consuming, reducing its practicality for clinical practice and research, which might explain the scarce reports on this outcome to date. 21 Scarcity in planimetry reports for assessing repigmentation necessitated the adoption of multiple other endpoints pertaining to speed of response, percentage of patients showing moderate to excellent (50–100%) repigmentation, cosmetic matching, patient satisfaction, and technique tolerability, taking into consideration both physician and patients’ perspectives.…”

Section: Discussionmentioning

confidence: 99%

Transverse Needling After Autologous Mini-Punch Grafts Improves Repigmentation in Stable Non-Segmental Vitiligo

Ragab¹,

Zagh

Farid³

2021

CCID

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Background: Repigmentation remains the primary target in vitiligo treatment. Melanocyte transfer procedures are often required for repigmenting stable, resistant vitiligo lesions necessitating procedural optimization and comparative evaluation. In the current study, we aimed to assess the additive value of weekly transverse needling sessions after mini-punch grafting for repigmenting stable non-segmental vitiligo lesions versus either procedure alone. Methods: Eighty lesions, included in 20 stable non-segmental vitiligo patients, were randomly allocated to each of the three treatment groups (line-1, mini-punch grafting; line-2, needling; and line-3, combined grafting and needling) and to a fourth control group receiving non-procedural treatment (line-4). Oral mini-pulse steroids and narrow-band ultraviolet-B sessions were administered to all patients for 3 months before and 6 months after the interventions. The extent of repigmentation was assessed using planimetry. Secondary outcomes were the time to first repigmentation response, cosmetic matching, and patient satisfaction. Blinding and allocation concealment were not feasible owing to the intervention nature and within subject design. Results: Mini-punch grafting followed by weekly needling for 6 months achieved the fastest response and highest extent of repigmentation. Mini-punch grafts and transverse needling alone provided better results than the control group. No steroid-associated side effects were reported. Conclusion:Weekly needling sessions after mini-punch grafting hastened and improved the repigmentation extent of stable, resistant, non-segmental vitiligo lesions and should be considered during treatment planning.

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“…Four methods for UV exposure in vitiligo photography are as follows: (i) hand‐held Wood’s lamps (Wood’s lamps), these are the most commonly known in the field of dermatology and vitiligo, (ii) soft boxes with UV lamps without the translucent cloths (soft boxes), by reflecting the light towards the patient these can potentially reduce shadow forming, (iii) UV flash attached to the camera (camera flash), this device is potentially easy to use, and (iv) separate high output UV flash (high output flash), described in a previous study by van Geel et al All four methods are shown in Fig. .…”

Section: Introductionmentioning

confidence: 99%

“…These scoring systems could benefit from large area photography. The UV set‐up may influence the outcomes of research urging efforts for optimization and standardization . The objective of our study was to compare UV light set‐ups for vitiligo photography regarding image quality and ease of use.…”

Section: Introductionmentioning

confidence: 99%

UV light set‐ups for vitiligo photography, a comparative study on image quality and ease of use

Uitentuis

Bekkenk

Geel

et al. 2019

Acad Dermatol Venereol

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BackgroundUltraviolet (UV) light is an essential tool to assess the extent, spreading and staging of vitiligo. Different UV light set‐ups are used for vitiligo photography, including the following: (i) hand‐held Wood’s lamps; (ii) soft boxes with UV lamps; (iii) UV flash attached to the camera; and (iv) high output UV flash.ObjectiveOur objective was to compare UV light set‐ups for vitiligo photography regarding image quality and ease of use.MethodsPatients with vitiligo lesions with unclear borders were included. Two images were made with all four UV set‐ups per patient, for a large and a small area. Image quality was scored separately by three blinded vitiligo experts on five criteria: overall quality, clearness of borders, contrast and sharpness and for larger areas the shadows. The two professional medical photographers were asked to score the ease of use for each set‐up.ResultsA total of 88 photos were assessed from 11 patients. For larger areas, the frequency of a ‘good’ or ‘very good’ overall quality rating was 12.1% (Wood’s), 6.1% (soft boxes), 15.2% (camera flash) and 78.8% (high output flash). For smaller areas, the score ‘good’ or ‘very good’ was given to 54.5%, 3%, 66.6% and 84.8% in the same order. For the shadow criteria, each set‐up scored below 40% on a 'good' or 'very good' score. The high output flash was scored as most easy to use by the photographers.ConclusionWhen comparing four different UV light set‐ups for vitiligo photography, we concluded that the UV set‐ups strongly influenced the quality scores of the obtained images. The high output flash scored best for both small and large areas and for ease of use. For small areas, Wood’s lamp and camera flash were acceptable. All set‐ups scored badly for shadows, and more research is needed to find the optimal exposure to avoid shadows.

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Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis

Cited by 16 publications

References 8 publications

Mechanisms of melanocyte death in vitiligo

Mechanisms of melanocyte death in vitiligo

Transverse Needling After Autologous Mini-Punch Grafts Improves Repigmentation in Stable Non-Segmental Vitiligo

UV light set‐ups for vitiligo photography, a comparative study on image quality and ease of use

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