Reference Limits for Reticulocyte Haemoglobin Content in Healthy Infants

Löfving, Anders; Andersson, Ola; Hellström-Westas, L; Domellöf, Magnus

doi:10.1038/pr.2011.1037

Cited by 2 publications

(7 citation statements)

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“…). In both VLBW and iron‐sufficient term infants studied longitudinally , RET‐He was highest at birth and subsequently declined. As expected, published reports of children and adults with IDA had significantly lower RET‐He values relative to iron‐sufficient individuals .…”

Section: Resultsmentioning

confidence: 99%

“…Infant steady‐state RET‐He values after 4 days of age were compared to RET‐He values for iron‐sufficient groups from the literature that included 2 days old term infants , 6 months to 18 years old children , and adults (; Fig. ).…”

Section: Resultsmentioning

confidence: 99%

“…Only human studies of infants, children, and adults with "reticulocyte hemoglobin content," "RET-He," "CHr," "reticulocyte indices," and/or "hematological indices" were included. Ten publications were identified (6,7,10,11,15,(22)(23)(24)(25)(26). To locate additional publications with original RET-He data, the reference section of these ten papers were reviewed by three of the coauthors (RA, DN, and JW).…”

Section: Literature Reviewmentioning

confidence: 99%

“…No additional references were found. Of the ten publications, seven contained RET-He variance data allowing comparison with the present study's VLBW infants (6,7,10,11,15,25,26).…”

Section: Literature Reviewmentioning

confidence: 99%

“…These indices include the reticulocyte hemoglobin content “CHr” parameter of the Bayer H٭3 and ADVIA 120 systems (Bayer Diagnostics, Tarrytown, NY), and “RET‐He” parameter of the Sysmex (Kobe, Japan; ). While normal values for RET‐He have been published for term infants , children , and adults , RET‐He values for premature newborn infants have not.…”

Section: Introductionmentioning

confidence: 99%

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Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Al-Ghananim

Nalbant

Schmidt

et al. 2015

Clinical Laboratory Analysis

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Background Reticulocyte hemoglobin content (RET-He)—an established indicator of iron status in children and adults—was determined in very low birth weight (VLBW) infants. Methods Longitudinal retrospective RET-He data in 26 VLBW neonates during the first month of age were compared with: 1) concurrent complete blood counts (CBC) including hemoglobin (Hb) concentration, reticulocyte count, and immature reticulocyte fraction (IRF), and erythropoietin (EPO) levels; 2) clinical variables; and 3) RET-He data from the literature for term infants, children, and adults. Results RET-He within 24 hr following birth was 31.8±1.1 pg (mean±SEM). This was followed by an abrupt, significant decline to 28.3±1.1 pg at 2–4 days, and to steady state levels of 28.4±0.5 pg thereafter. The changes in RET-He were mirrored by changes in plasma EPO, reticulocyte count, and IRF, but not Hb. Steady state RET-He values after 4 d were significantly lower than RET-He values for term infants, children, and adults (31.6±0.11, 32.0±0.12, and 33.0±0.13 pg, respectively). Conclusion Although RET-He values in VLBW infant were lower than term infants, children and adults, the significance and mechanism(s) responsible are unknown. The present VLBW infant data are relevant to investigations assessing hemoglobinization following treatment with recombinant human EPO (r-HuEPO) and/or iron.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

“…No additional references were found. Of the ten publications, seven contained RET-He variance data allowing comparison with the present study's VLBW infants (6,7,10,11,15,25,26).…”

Section: Literature Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Al-Ghananim

Nalbant

Schmidt

et al. 2015

Clinical Laboratory Analysis

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Features of modern clinical research blood analysis in the assessment of erythropoiesis in deep-premature newborns

et al. 2021

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One of the urgent problems of nursing premature babies is the timely prediction, diagnosis and treatment of anemia, the frequency of which reaches 90%. Of particular importance is the study of reticulocytic blood parameters in deep-premature newborns, since the correct assessment of hemograms is crucial in the management of this category of children. To determine the characteristics of red blood cells and reticulocyte parameters of venous blood hemogram in premature newborns 24-32 weeks of gestation in the dynamics of the neonatal period. 111 newborns were examined at 24-32 weeks of gestation in the early neonatal period (on day 3-7) and at the age of 1 month of life. Along with standard diagnostic procedures, in accordance with current clinical recommendations and standards, 28 parameters of erythrocyte and reticulocyte hemogram parameters were determined for children. Venous blood was examined using an automatic hematological analyzer ADVIA 2120i, Siemens, USA. In deep-premature newborns in the early neonatal period, there is a high activity of erythropoiesis, respectively, the severity of respiratory and metabolic disorders with rejuvenation of reticulocytic subpopulations. Negative values of Delta hemoglobin were found against the background of a decrease in the average amount of hemoglobin in reticulocytes in children 24-27 weeks of gestation, which characterizes the lowest values of iron availability for erythropoiesis in this category of newborns. It is shown that a decrease in reticulocyte counts and normochromia in all examined newborns by the age of one month are accompanied by high levels of immature reticulocyte fraction, while a third of children still have limited iron availability for erythropoiesis.

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Reference Limits for Reticulocyte Haemoglobin Content in Healthy Infants

Cited by 2 publications

References 0 publications

Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Features of modern clinical research blood analysis in the assessment of erythropoiesis in deep-premature newborns

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