Reference Intervals of Central Aortic Blood Pressure and Augmentation Index Assessed with an Oscillometric Device in Healthy Children, Adolescents, and Young Adults from Argentina

Diaz, Alberto Alejandro; Zócalo, Yanina; Fischer, Edmundo Cabrera

doi:10.1155/2018/1469651

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…Children with obesity have been reported to present with lower AIx compared with normal weight children ( 12 ). A negative correlation has been reported between body mass index (BMI) and central AIx ( 14 ). However, some studies found no association of childhood obesity with AIx ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children

et al. 2021

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Objective: Central hemodynamics are related to cardiovascular (CV) outcomes in adults, but associations with childhood CV risk remain unclear. The study aimed to investigate the association of obesity, physical activity, and fitness with parameters of central pulse wave reflection in young prepubertal children.Methods: In this cross-sectional study, 1,324 primary school children (aged 7.2 ± 0.4 years) were screened for parameters of pulse wave reflection such as augmentation index (AIx), central pulse pressure (CPP), body mass index (BMI), and cardiorespiratory fitness (CRF) by standardized procedures for children.Results: The mean AIx and AIx@75 were 22.2 ± 7.7 and 29.2 ± 9.2%, respectively. With each unit increase in BMI, AIx [−0.226 (−0.328; −0.125)%] and AIx@75 [−0.444(−0.660; −0.229)%] decreased, whereas peak forward pulse wave increased (p < 0.001). Increasing BMI was associated with higher CPP, but did not remain significant after adjustment for CRF and heart rate. One unit increase in CRF was associated with lower AIx@75 [−0.509(−0.844; −0.173)%, p = 0.003] and lower reflection magnitude [RM: −0.559 (−0.890; −0.227), p = 0.001], independent of body weight and height. Girls had significantly higher AIx, AIx@75, peak backward pulse wave, and RM compared with boys.Conclusion: Childhood obesity was associated with higher CPP but lower augmentation of the reflected pulse wave in children. Assessment of central blood pressures appears to be a valuable asset to childhood CV risk screening. The validity of augmentation indices during childhood development and the association with early vascular aging in children need to be verified in long-term follow-up studies. Physical activity and fitness have the potential to improve vascular hemodynamics in susceptible children and, thus, counteract vascular aging.Trial registry: ClinicalTrials.gov: Exercise and Arterial Modulation in Youth. Identifier: NCT02853747; URL: https://clinicaltrials.gov/ct2/show/NCT02853747.

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Section: Introductionmentioning

confidence: 99%

Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children

et al. 2021

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“…Существуют два подхода к оценке ригидности магистральных артерий: одномоментная оценка и определение в ходе суточного мониторирования АД. Одномоментная оценка более целесообразна для проведения крупных популяционных исследований [21][22][23]. Значения артериальной жесткости могут варьировать в течение суток и зависят от положения пациента, степени физической активности и других факторов.…”

Section: Discussionunclassified

“…до 113 мм рт.ст., у мальчиков -от 97,7 до 116,9 мм рт.ст. Эти показатели были ниже, чем в немецкой популяции [22]. Оценка центрального АД у студентов по данным одномоментного определения параметров центральной и периферической гемодинамики при использовании осциллометрического метода позволила установить, что факторы риска развития сердечно-сосудистых заболеваний ассоциируются с нарушением жесткости магистральных артерий в виде повышения центрального систолического АД и скорости распространения пульсовой волны [7].…”

Section: таблица 5 взаимосвязь уровней артериальной ригидности и средних значений суточного мониторирования периферического артериальногоunclassified

“…В нашем исследовании у подростков с артериальной гипертензией выявлены достоверно более высокие значения центрального систолического давления по сравнению с таковым в группе с нормальным АД как в дневные и ночные часы, так и в среднем за сутки. При этом центральное систолическое давление не превышало 95-го процентиля распределения этого признака для соответствующего пола и возраста [22,24].…”

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Early diagnosis of increased stiffness of great vessels in adolescents with functional pathology of vegetative genesis

Леонтьева

Ковалев

Школьникова

et al. 2021

Ross. vestn. perinatol. pediatr.

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40 adolescents aged 15–17 years with functional cardiovascular pathology of vegetative origin underwent a 24-hour blood pressure monitoring (using the oscillometric method BPLabVasotens, Peter Telegin LLC, Nizhny Novgorod) with an assessment of central blood pressure parameters and rigidity of the main arteries.The scientists found significantly higher values of central systolic pressure during the day and night hours in the group of adolescents with arterial hypertension (n=13) compared to adolescents with normal blood pressure (n=27). They determined significantly higher values of the pulse wave velocity both during 24 hours and in the day and night hours in the group with arterial hypertension compared to the group of adolescents with normal blood pressure. No differences were found in the parameters of the propagation time of the reflected pulse wave and the augmentation index. The time of the reflected pulse wave propagation was significantly lower at nighttime compared to the daytime. In the group with arterial hypertension, the rate of pulse wave propagation in the aorta correlated only with the values of diastolic pressure over 24 hours and diastolic pressure in the daytime. In the adolescents with normal blood pressure, the pulse wave velocity correlated with systolic and pulse blood pressure. The augmentation index in the group of adolescents with arterial hypertension correlated with diastolic pressure, in contrast to the group of adolescents with normal blood pressure, where such a correlation was not detected.

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“…A number of epidemiological studies have used adult-validated devices to establish cSBP and cAIx references values in children [29][30][31][32]. Furthermore, ongoing hemodynamic research in the young has led to promising developments for a potential role of central hemodynamic indices as tools for cardiovascular risk stratification or markers of early disease [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Effect of Body Habitus and Heart Rate on Accuracy of Aortic-Radial Transfer Functions for Predicting Central Hemodynamic Indices in Growing Children

Cai¹,

Qasem²,

Butlin³

et al. 2020

Artery Res

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Central Systolic Blood Pressure (cSBP) and Central Augmentation Index (cAIx) have been independently associated with cardiovascular risk in adults, and can be estimated using a generalized peripheral-to-central transfer function. We hypothesize that transfer function accuracy and precision will be influenced by degree of growth and change in body habitus during periods of growth, such as in childhood. We studied the pulse pressure waveforms of 91 healthy children at 8-years of age, and subsequently at 14-years of age. Waveforms were obtained by high-fidelity applanation tonometry of the radial and carotid arteries. Individualized radial-to-carotid transfer functions were formulated at 8-years of age and applied at 14-years of age to estimate cSBP and cAIx. Accuracy was defined as the difference between directly measured and predicted values, and precision as the residuals. Changes in weight (vs. error: b = −0.22, p = 0.04; vs. residuals: b = 0.30; p < 0.01) and body mass index (vs. residuals: b = 0.28, p < 0.01), between 8 and 14 years of age were associated with accuracy and precision of individualized transfer functions in predicting cSBP at 14 years of age. Change in weight (vs. residuals: b = 0.30; p < 0.01) and heart rate (vs. residuals b = 0.32, p < 0.01) were associated with the precision in predicting cAIx. Changes in body habitus and heart rate over a 6-year period of growth are associated with the predictive accuracy and precision of individualized transfer functions in children suggestive of changes in the frequency response characteristics of an individual's vascular system during growth periods.

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Reference Intervals of Central Aortic Blood Pressure and Augmentation Index Assessed with an Oscillometric Device in Healthy Children, Adolescents, and Young Adults from Argentina

Cited by 13 publications

References 34 publications

Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children

Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children

Early diagnosis of increased stiffness of great vessels in adolescents with functional pathology of vegetative genesis

Effect of Body Habitus and Heart Rate on Accuracy of Aortic-Radial Transfer Functions for Predicting Central Hemodynamic Indices in Growing Children

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