Reference intervals of bone turnover markers determined by using their curve-fitting valley for adult females in China

Abstract

This study found that the changes of level with age of BTMs in Chinese women present an optimal goodness-of-fit according to the cubic regression model. The fitting valley corresponds to the BMD fitting peak and may possibly be an effective means of determining the BTM reference intervals.

Reference Intervals for Bone Turnover Markers in Korean Healthy Women

“…These changes are due to abrupt increase of bone remodeling after menopause, and similar results are also reported in other studies. [21,23,[27][28][29][30][31] Although the RIs for BTMs in this study were similar to many other previous studies, there are some reports showing ethnic or geographic differences of BTMs. In a study of 637 women from 4 countries (UK, France, Belgium, and USA), serum CTX and N-terminal propeptide of type I collagen were significantly higher in France relative to other countries.…”

“…[16] Various premenopausal reference age ranges such as 30 to 45 years, 35 to 45 years, and 30 to 39 years and RIs for BTMs based on their data have been published in a number of studies. [5,[17][18][19][20][21][22][23][24] It have been proposed in several studies that the target therapeutic goal of antiresorptive therapy is to reduce BTMs to lower half of the normal reference range of the premenopausal women. [2,8,11,25] In this study, we determined the RI of 2 BTMs, serum Cterminal telopeptides of type I collagen (CTX) and osteocalcin, in Korean healthy women with normal spinal BMD.…”

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

“…Levels of osteocalcin, iPTH, bone formation markers including N-terminal propeptide of type I procollagen (P1NP) and bone resorption markers β C-terminal telopeptide of type Ⅰ collagen (β-CTX) were measured by electrochemiluminescence in the Clinical Laboratory of Endocrinology at the Second Xiangya Hospital of Central South University (Changsha, Hunan, China) to evaluate effects of a single dose of IM D2 on bone turnover (26,27). The interassay CV of the assay was 20%.…”

Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women

“…All subjects were screened using a detailed questionnaire, historical intake, and physical examination. 15,16 According to the World Health Organization (WHO) definition 17 and the BMD reference databases established by Wu XY et al and Hou YL et al, 15,16 subjects with a BMD of 1.0 SD or 2.5 SD lower than the peak BMD of the same gender (T-scores ≤−1.0 and ≤−2.5) were determined to be osteopenic or osteoporotic, respectively.…”

“…BMD was measured by dual energy X-ray absorptiometry (DXA) using a Lunar device (Lunar DPX IQ, Waltham, MA, USA) for various skeletal regions, including the posteroanterior lumbar spine (Lumbar spine, L1-L4) and the left femoral neck. 15,16 All calculations were performed using SPSS V19.0 for Windows (SPSS Inc., Chicago, IL, USA). The results are provided as the mean and standard deviation (mean ± SD).…”