Reference intervals for whole blood viscosity using the analytical performance-evaluated scanning capillary tube viscometer

Jung, Ju Yeon; Lee, D.H.; Kim, K.T.; Choi, Munkee; Cho, Y.G.; Lee, H.S.; Choi, Songho; Lee, S.R.; Kim, D.S.

doi:10.1016/j.clinbiochem.2014.01.021

Cited by 30 publications

(29 citation statements)

References 12 publications

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“…For example, in female patients, there was no significant difference in both systolic and diastolic WBVs among NAFLD, CVH, and LC. The significant difference in WBV between NAFLD/CVH and LC reported by all the previous studies (1291416171819) was only found in male patients, not in female patients in the present study.…”

Section: Resultscontrasting

confidence: 64%

“…However, there were no statistically significant differences in systolic and diastolic WBV between liver diseases in female patients. Of note, systolic and diastolic WBV in patients with CLD enrolled in this study tended to be higher than those in healthy Koreans (systolic: median, 5.1 cP vs. 4.03 cP, diastolic: median, 15.8 cP vs. 10.63 cP) (9). These findings suggest that patients with CLD have higher blood viscosity than healthy controls, indicating the disturbance of microcirculation in liver; however, WBV decreases with progression of liver fibrosis.…”

Section: Resultsmentioning

confidence: 74%

“…In addition to the baseline blood tests, we measured WBV by using the automated scanning capillary tube viscometer (Hemovister, Ubiosis, Seongnam, Korea) at a low shear rate (5s −1 ) and a high shear rate (300s −1 ), respectively (9). WBV at a low shear rate reflects hemodynamical status with very low velocity as in microcirculation, in which RBCs can aggregate and thus increase the flow resistance at blood vessels.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, WBV at a low shear rate indicate blood viscosity at the diastolic status, and WBV at a high shear rate indicate blood viscosity at the systolic status. The reference intervals for WBV were 3.36–5.16 cP at 300 s −1 and 8.25–14.28 cP at 5s −1 as previously described (9). Detail theory and operating principle of the automated scanning capillary tube viscometer are given elsewhere (10).…”

Section: Methodsmentioning

confidence: 99%

“…Traditionally, a rotational cone-and-plate viscometer was used to measure blood viscosity, but this has not been widely used in clinical practice because of the risk of blood contamination and the need to calibrate the spring sensor. Recently, a new scanning capillary tube viscometer with disposable U-tubes is introduced, which measures blood viscosity over a wide range of shear rates (i.e., 1–1,000 1/s) (9101112). …”

Section: Introductionmentioning

confidence: 99%

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Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

et al. 2016

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Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = −0.25, diastolic: r = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.

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Section: Resultscontrasting

confidence: 64%

Section: Resultsmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

et al. 2016

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A Heterogeneous Multi-scale Model for Blood Flow

Czaja

Závodszky

Hoekstra

2020

Lecture Notes in Computer Science

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Vis-NIR spectroscopy with moving-window PLS method applied to rapid analysis of whole blood viscosity

et al. 2017

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A rapid analytical method of human whole blood viscosity with low, medium, and high shear rates [WBV(L), WBV(M), and WBV(H), respectively] was developed using visible and near-infrared (Vis-NIR) spectroscopy combined with a moving-window partial least squares (MW-PLS) method. Two groups of peripheral blood samples were collected for modeling and validation. Separate analytical models were established for male and female groups to avoid interference in different gender groups and improve the homogeneity and prediction accuracy. Modeling was performed for multiple divisions of calibration and prediction sets to avoid over-fitting and achieve parameter stability. The joint analysis models for three indicators were selected through comprehensive evaluation of MW-PLS. The selected joint analysis models were 812-1278 nm for males and 670-1146 nm for females. The root-mean-square errors (SEP) and the correlation coefficients of prediction (R) for all validation samples were 0.54 mPa•s and 0.91 for WBV(L), 0.25 mPa•s and 0.92 for WBV(M), and 0.22 mPa•s and 0.90 for WBV(H). Results indicated high prediction accuracy, with prediction values similar to the clinically measured values. Overall, the findings confirmed the feasibility of whole blood viscosity quantification based on Vis-NIR spectroscopy with MW-PLS. The proposed rapid and simple technique is a promising tool for surveillance, control, and treatment of cardio-cerebrovascular diseases in large populations. Graphical Abstract The caption/legend of the online abstract figure: The selected wavebands and the prediction effects for the three indicators of whole blood viscosity.

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Reference intervals for whole blood viscosity using the analytical performance-evaluated scanning capillary tube viscometer

Cited by 30 publications

References 12 publications

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

A Heterogeneous Multi-scale Model for Blood Flow

Vis-NIR spectroscopy with moving-window PLS method applied to rapid analysis of whole blood viscosity

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