Reference intervals for serum bilirubin, urea, and uric acid in healthy Chinese geriatric population

Yao, Yuanqing; Jiang, Hong-Min; Tang, Anliu; Xiang, Zhongyuan

doi:10.1002/jcla.22318

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The serum UA level was 266 ± 69 μmol/L in the PACG group and 269 ± 73 μmol/L in the control group ( Table 2 ; p = 0.71). The serum UA levels of all participants were within the reference range of UA in the healthy, elderly Chinese population (130–443 μmol/L for females and 179–461 μmol/L for males) [ 17 ]. In both groups, males had higher serum UA levels than females did (PACG patients: p = 0.002; controls: p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Liu,

Guo,

Gao

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Liu,

Guo,

Gao

et al. 2024

Heliyon

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“…The results of this study are summarized in Table 1 and Figure 2, which report relevant and useful cut-offs beyond which hyperuricemia can be defined in this sample and carefully extrapolated to the general population (similar efforts were done for haemoglobin [23], serum calcium and magnesium [24]). In the literature, population-based SUA RIs and ULNs are relatively sparse and vary considerably: for example, 2.6-8.2 mg/dL in an Indian population sample [25] or 3.01-7.75 mg/dL in men and 2.19-7.45 mg/dL in women in a healthy Chinese geriatric sample [26]. Regarding mean SUA levels, they seem to be ele- vated in Western countries: for example, in Italy only 17.6% of controls had SUA below 6 mg/ dL [27], while in the United States, NHANES I data showed mean SUA of 5.5 mg/dL in all, 6.22 mg/dL in men and 4.89 mg/dL in women [3].…”

Section: Discussionmentioning

confidence: 99%

Reference interval and upper decission limit for serum uric acid – an evidence-based approach on Romanian population using an a posteriori method

Codreanu

Popoviciu

Rezuş

et al. 2019

Revista Romana De Medicina De Laborator

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Introduction. There is accumulating evidence that high normal serum uric acid (SUA) levels of 6-7 mg/dL are associated with cardiovascular morbidity and metabolic syndrome (MetS), hence the need to redefine its upper limit of normal (ULN). We aimed to derive ULN based on statistics and evidence in a representative sample of the population and to observe its relation to MetS components. Methods. All SUA measurements form a university rheumatology hospital were extracted between January 5th 2010 and March 21st 2018. SUA levels were measured by a single biochemist a unique type of commercially available kit. Follow-up measurements, patients with diagnoses influencing SUA levels and outlying measurements were excluded. ULNs were studied using least square analysis. Results. Of the 22503 SUA measurements in the database, only 3318 came from normal individuals: 33.3% men (n=1105), 66.7% women (n = 2213). Least square analysis revealed the following SUA reference intervals (RI): 3.43-6.19 mg/dL for the combined sample; 4.44-7.01 mg/dL for men, 3.28-5.56 mg/dL for women. The values corresponding to the 66th percentile of each group presented lower ULNs: 5.36 mg/dL for all, 6.10 mg/dL for men, 4.90 mg/dL for women. The prevalence of hyperuricemia increased from 13.8% (manufacturer’s gender-specific ULN) to 19.9% (derived ULN). Mean SUA levels significantly increased with the number of MetS components. Conclusion. We recommend that hyperuricemia should be defined using a statistical approach of ULN selection corresponding to the genderand population-specific 66th percentile of data range.

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Baseline Serum Bilirubin and Risk of First Stroke in Hypertensive Patients

Wang

Zhang

et al. 2020

JAHA

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Background Data on the association between serum bilirubin and the risk of stroke are limited and inconclusive. We aimed to evaluate the association between serum bilirubin and the risk of first stroke and to examine any possible effect modifiers in hypertensive patients. Methods and Results Our study was a post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial). A total of 19 906 hypertensive patients were included in the final analysis. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% CIs for the risk of first stroke associated with serum bilirubin levels. The median follow‐up period was 4.5 years. When serum total bilirubin was assessed as tertiles, the adjusted HR of first ischemic stroke for participants in tertile 3 (12.9–34.1 μmol/L) was 0.75 (95% CI, 0.59–0.96), compared with participants in tertile 1 (<9.3 μmol/L). When direct bilirubin was assessed as tertiles, a significantly lower risk of first ischemic stroke was also found in participants in tertile 3 (2.5–24.8 μmol/L) (adjusted HR, 0.77; 95% CI, 0.60–0.98), compared with those in tertile 1 (<1.6 μmol/L). However, there was no significant association between serum total bilirubin (tertile 3 versus 1: adjusted HR, 1.45; 95% CI, 0.89–2.35) or direct bilirubin (tertile 3 versus 1: adjusted HR, 1.27; 95% CI, 0.76–2.11) and first hemorrhagic stroke. Conclusions In this sample of Chinese hypertensive patients, there was a significant inverse association between serum total bilirubin or direct bilirubin and the risk of first ischemic stroke.

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Reference intervals for serum bilirubin, urea, and uric acid in healthy Chinese geriatric population

Abstract: The RIs of TBIL, DBIL, UR, and UA were established within apparently healthy geriatric Chinese population according to CLSIC28-A3 document, providing a reference for the clinical.

Cited by 3 publications

References 9 publications

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Reference interval and upper decission limit for serum uric acid – an evidence-based approach on Romanian population using an a posteriori method

Baseline Serum Bilirubin and Risk of First Stroke in Hypertensive Patients

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