“…Samples for measurement of PAPP-A were drawn before the first dose of heparin was given, every 15 min for the first 4½ h, and every 30 min for the following 4 h (i.e. after 15,30,45,60,75,90,105,120,135,150,165,180,195,210,225,240,255,270, 300, 330, 360, 390, 420, and 450 min), giving a total of 25 samples. In addition to serum samples for PAPP-A measurement, we also drew blood for monitoring activated partial thromboplastin time (APTT) at the same time points.…”