Reference centiles for the gross motor function measure and identification of therapeutic effects in children with cerebral palsy

Abstract

The presented method helps to guide the clinician to track the individual patient's gross motor development and assess the additional effect of an additionally applied intervention while taking into account the expected progression of gross motor function under standard of care.

Motor Function Improvement in Children with Ataxia Receiving Interval Rehabilitation, Including Vibration-Assisted Hometraining: A Retrospective Study

“…The change related to the training was not only statistically significant, but also probably clinically relevant [ fect size for the GMFM-66 and a medium effect size for the 1MWT [18]. Further improvement in the follow-up, reflects the age-dependent natural development of the non-progressive disease, similar to findings reported among children with cerebral palsy over a six-month period [4]. Such a natural improvement is often not expected among children with progressive ataxia [21].…”

“…Intensive training including vibration-assisted home-training, significantly improved the GMFM-66 of children with progressive and non-progressive ataxia, and the 1MWT of children with non-pro-gressive ataxia. The GMFM-66 is validated and routinely used for children with ataxic CP [4,25].…”

“…Empirical data of children with ataxic cerebral palsy (CP) underline the effectiveness of intense training using vibration-assisted therapy [4,28]. Vibration-assisted training effectively utilises the mono-synaptic reflex through external muscular stimulation.…”

One-Minute Walk Test in Children with Cerebral Palsy GMFCS Level 1 and 2: Reference Values to Identify Therapeutic Effects after Rehabilitation

“…The study design has already been reported. 18 Only assessments performed using the same aids, such as splints, in all three investigations were included in the analysis.…”

“…The methodology for the calculation of Z-scores, adjustment of skewness L(a), median value M(a) and the coefficient of variation S(a), as well as the calculation of differences between two z-scores and their correlation coefficients r, has been described in a previous publication. 18 Correlation coefficients r of the Z-Scores at M6 and M12 were used to calculate the distribution of centile changes. We further applied LOESS regression to the generated correlations coefficients r. Calculation of Z-scores was performed by applying a modified Box-Cox transformation:…”