We identify the different contributions to quantum interference in a mesoscopic metallic loop in contact with two superconducting electrodes. At low temperature, a flux-modulated Josephson coupling is observed with strong damping over the thermal length LT . At higher temperature, the magnetoresistance exhibits large h/2e-periodic oscillations with 1/T power law decay. This flux-sensitive contribution arises from coherence of low-energy quasiparticles states over the phasebreaking length Lϕ. Mesoscopic fluctuations contribute as a small h/e oscillation, resolved only in the purely normal state.PACS numbers: 74.50.+r, 74.80.Fp, 73.50.Jt, 73.20.Fz In a disordered metal at low temperature, electronic coherence persists over the phase-breaking length L ϕ [1]. Weak localization, which consists in electron coherent backscattering along a closed diffusion path, induces corrections of the conductance of order the quantum of conductance e 2 /h. The sensitivity of this process to an Aharonov-Bohm flux leads to φ 0 = h/2e periodic oscillations of the resistance of a mesoscopic loop [2,3]. Hybrid systems made of Normal (N) and Superconducting (S) materials are the scene for new physics, due to the Andreev reflection and the proximity effect. At low temperature (k B T ≪ ∆), incident electrons have an energy much smaller than the gap ∆ of S and are Andreevreflected at the N-S interface into a coherent hole. Spivak and Kmelnitskii investigated the effect of Andreev reflection on weak localization in a S-N-S geometry [4]. The N metal conductance was predicted to be sensitive to the phase difference between the two superconductors with a period of π, leading to a h/4e flux-periodicity in a loop. Petrashov et al. [5] and de Vegvar et al.[6] measured phase-sensitive transport in mesoscopic N-S metallic systems. The interpretation of Ref.[5] results in terms of weak localization is not consistent with the large amplitude of the effect [7]. In fact, the proximity effect in such mesoscopic systems can lead to a zero-resistance state with a well-defined Josephson current [8] if N-S interfaces have high transparency. In a two-dimensional electron gas, Dimoulas et al. also observed, beyond the Josephson coupling, large effects of quasiparticle interference on the resistance [9]. Recently, there has been considerable interest in coherent transport through mesoscopic N-S tunnel junctions [10,11]. Confinement of electrons and holes by disorder in N induces coherent multiple Andreev reflections, which enhance the low-temperature subgap conductance [12]. This is exemplified by the flux-modulation of the subgap current in the case of a fork-shaped S electrode [13]. Volkov showed that this behaviour may be explained by the appearance, despite the barrier, of a small pair-amplitude in N [14]. This suggests that the proximity effect could explain most of the surprising data on resistive transport in mesoscopic N-S devices, even if classical estimates fail to agree with experimental results.At present, a clear identification of the different c...