Reelin immunoreactivity in lymphatics and liver during development and adult life

Samama, Brigitte; Boehm, Nelly

doi:10.1002/ar.a.20202

Cited by 39 publications

(39 citation statements)

References 28 publications

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“…105 Reelin, a glycoprotein secreted by Cajal-Retzius cells, is a serine protease of the extracellular matrix, which rapidly degrades fibronectin and laminin. 106 The immunohistochemical staining in human and rat fetus demonstrated the expression of reelin on LECs, but not on BECs, 107 indicating it may contribute to the special phenotype both during lymphangiogenesis and in mature lymphatics. Kaposi's sarcoma-associated herpesvirus infection of human dermal microvascular endothelial cells induces significant upregulation of the lymphatic lineage-specific gene, reelin, 108 indicating the origin of Kaposi's sarcoma from LECs.…”

Section: Integrins Endostatin Reelin Il-7 Mmps and Lymphaticsmentioning

confidence: 98%

Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix

2006

Lymphatic Research and Biology

108

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Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-associated disorders (e.g., wound healing, lymphedema and tumor metastasis) have focused renewed attention on the intrinsic relationship between lymphatic endothelial cells (LECs) and extracellular matrix (ECM) microenvironment. ECM molecules and remodeling events play a key role in regulating lymphangiogenesis, and the "functionality"-relating molecules, especially hyaluronan, integrins, reelin, IL-7, and matrix metalloproteinases, provide the most fundamental and critical prerequisite for LEC growth, migration, tube formation, and survival, although lymphangiogenesis is directly or/and indirectly controlled by VEGF-C/-D/VEGFR- 3- Prox-1-, Syk/SLP76-, podoplanin/Ang-2/Nrp-2-, FOXC2-, and other signaling pathways in embryonic and pathological processes. New knowledge regarding the differentiation of initial lymphatics should enable improvements in understanding of a variety of cytokines, chemokines, and other factors. The lymphatic colocalization with histochemical staining by using the novel molecular markers (e.g., LYVE-1), along with subsequent injection technique with ferritin or some tracer, will reveal functional and structural features of newly formed and preexisting lymphatics. Growing recognition of the multiple functions of ECM and LEC molecules for important physiological and pathological events may be helpful in identifying the crucial changes in tissues subjected to lymph circulation and ultimately in the search for rational therapeutic approaches to prevent lymphatic-associated disorders.

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Section: Integrins Endostatin Reelin Il-7 Mmps and Lymphaticsmentioning

confidence: 98%

Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix

2006

Lymphatic Research and Biology

108

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“…The stellate cells of the fetal liver express desmin [23,24], β3-integrin, nestin [24], CRBP-1 [25], N-CAM [26], and reelin [27]. Some researchers consider that these cells are derived from mesenchymal cells of septum transversum, which form the submesothelial layer under the liver capsule [26,28,29], but their epithelial origin cannot be excluded [30].…”

Section: Hepatic Stellate Cellsmentioning

confidence: 99%

Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

Payushina

2012

ISRN Cell Biology

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Hematopoiesis is the main function of the liver during a considerable period of mammalian prenatal development. Hematopoietic cells of the fetal liver exist in a specific microenvironment that controls their proliferation and differentiation. This microenvironment is created by different cell populations, including epitheliocytes, macrophages, various stromal elements (hepatic stellate cells, fibroblasts, myofibroblasts, vascular smooth muscle and endothelial cells, mesenchymal stromal cells), and also cells undergoing epithelial-to-mesenchymal transition. This paper considers the involvement of these cell types in the regulation of fetal liver hematopoiesis.

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“…It has been suggested that defects in this pathway impair brain development and contribute to the pathogenesis of Alzheimer disease (9). Further studies have demonstrated that some extraneuronal tissues also express reelin (10), suggesting a biological role(s) of reelin beyond neuronal development.…”

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confidence: 99%

Up-regulation of ATP Binding Cassette Transporter A1 Expression by Very Low Density Lipoprotein Receptor and Apolipoprotein E Receptor 2

Chen

Guo

Okoro

et al. 2012

Journal of Biological Chemistry

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Background: VLDLR and apoER2 are receptors for reelin and apoE. Results: Reelin or apoE3 induced macrophage ABCA1 expression and increased cholesterol efflux. Down-regulation of VLDLR, apoER2, or inhibition of Dab1, PI3K, PKC and Sp1 attenuated reelin-or apoE3-induced ABCA1 expression. Conclusion: Activation of VLDLR-and apoER2-mediated signaling up-regulates ABCA1 expression. Significance: Up-regulation of ABCA1 expression is a novel function of VLDLR and apoER2.

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Reelin immunoreactivity in lymphatics and liver during development and adult life

Cited by 39 publications

References 28 publications

Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix

Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix

Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

Up-regulation of ATP Binding Cassette Transporter A1 Expression by Very Low Density Lipoprotein Receptor and Apolipoprotein E Receptor 2

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