Reduplicative Paramnesia After a Right Frontal Lesion

Lee, Koomi; Shinbo, Michiko; Kanai, Hinako; Nagumo, Yumi

doi:10.1097/wnn.0b013e31821129b7

Cited by 16 publications

(6 citation statements)

References 19 publications

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“…Patients with a lesion on the same side can also sometimes confabulate, show neglect, have a phobia of images and objects presented to their left (levophobia), 9 or even believe these are in another place (reduplicative paramnesia). 10 Interestingly, the patient in our case was left-handed, displayed symptoms consistent with misoplegia in the right arm, and showed right hemisphere lesions, notwithstanding her neurological dominance.…”

Section: Discussionmentioning

confidence: 50%

Misoplegia and dementia: a case study

Santos

Ferreira

Hora

et al. 2021

Dement. neuropsychol.

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ABSTRACT. Brain-damaged patients can develop abnormal attitudes towards their deficits. Misoplegia is one such example, involving exaggerated aversion to an impaired limb, sometimes associated with hatred of paresis and verbal or physical abuse directed at the paretic limb. Few studies or reports on this disorder are available in the literature, prompting the present case report of a patient with misoplegia and vascular dementia.

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Section: Discussionmentioning

confidence: 50%

Misoplegia and dementia: a case study

Santos

Ferreira

Hora

et al. 2021

Dement. neuropsychol.

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“…However, it fits well these notions about the potential consequences of right hemisphere lesions on selfawareness. The analogy is further reinforced by the concomitant presence of reduplicative paramnesia, which has been associated with frontal damage in the right hemisphere [11].…”

Section: Discussionmentioning

confidence: 99%

The delusion of the Master: the last days of Henry James

Bartolomeo

2013

Neurol Sci

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The novelist Henry James shared with his brother William, the author of the Principles of Psychology, a deep interest in the ways in which personal identity is built through one's history and experiences. At the end of his life, Henry James suffered a vascular stroke in the right hemisphere and developed a striking identity delusion. He dictated in a perfectly clear and coherent manner two letters as if they were written by Napoleon Bonaparte. He also showed signs of reduplicative paramnesia. Negative symptoms resulting from right hemisphere damage may disrupt the feelings of "warmth and intimacy and immediacy" and the "resemblance among the parts of a continuum of feelings (especially bodily feelings)", which are the foundation of personal identity according to William James. On the other hand, a left hemisphere receiving inadequate input from the damaged right hemisphere may produce positive symptoms such as delusional, confabulatory narratives. Other fragments dictated during Henry James's final disease reveal some form of insight, if partial and disintegrated, into his condition. Thus, even when consciousness is impaired by brain damage, something of its deep nature may persist, as attested by the literary characteristics of the last fragments of the Master.

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“…Additionally, social behavioral abnormalities, including apathy, disinhibition, eating disorders and aberrant motor behaviors, are correlated with tissue loss of the right hemisphere in AD patients [31] . Right hemisphere dysfunction, structural lesions, or hypo-metabolism could cause delusions, and impaired ego boundaries, self-monitoring and familiarity to stimuli [32][33][34] , whereas dysfunction on the left hemisphere may cause unchecked false explanations to outer stimuli [35] . Furthermore, comprehension and expression are mainly operated by the right hemisphere [30] , which may explain why right hemisphere dysfunction might induce poor impulse control, childish behavior and poor modulated affect [31] .…”

Section: Discussionmentioning

confidence: 99%

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

Lin

Kao

et al. 2016

Transl. Neurosci. Clin.

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KEYWORDSAlzheimer's diseas; white matter changes; leukoaraiosis; behavioral and psychological symptoms of dementia Objective:The frontal lobe may be involved in circuits associated with depression, apathy, aggression, and other psychiatric symptoms. Although white matter changes (WMC) are related to the severity of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD), it is unclear which part of the WMC may play the most important role in BPSD. This study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD patients. Methods: Among patients diagnosed with Alzheimer's disease between 2009 and 2014, 387 patients were retrospectively reviewed after those with pre-existing organic brain syndrome, psychiatric diseases, or toxic-metabolic encephalopathy were excluded. Patients' demographic and laboratory data, WMC measured with brain computed tomography and scored using the age-related white matter changes (ARWMC) scale, and neuropsychological tests, including the cognitive abilities screening instrument (CASI), the Mini-Mental State Examination (MMSE), the clinical dementia rating scale with sum-box (CDR-SB), and the neuropsychiatric inventory (NPI) were analyzed. Results: There was no significant difference in the NPI between patients with and without a history of stroke, hypertension, and diabetes. No significant difference in the NPI was identified between different sexes or different Apolipoprotein E (APOE) alleles. The NPI score was significantly correlated with the duration of education (r = -0.4515, P = 0.0172), CASI (r = -0.2915, P < 0.0001), MMSE (r = -0.8476, P < 0.0001), and CDR-SB (r = 2.2839, P < 0.0001). WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC (P = 0.0255). After adjusting for age, duration of education, and CASI, WMC in the right frontal lobe remained significantly associated with the NPI score (β = 3.8934, P = 0.042). Conclusions: WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia diagnosis. Further studies are necessary to confirm whether controlling the risk factors of WMC can slow the progression of BPSD.Citation Lin TC, Lin YH, Kao LL, Kao YH, Yang YH, Chou PS, Wu MN. An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients.

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Reduplicative Paramnesia After a Right Frontal Lesion

Abstract: A localized lesion in the right inferior posterior frontal subcortical area can cause cognitive dysfunction that may develop into reduplicative paramnesia. Paranoid personality and the change of the patient's hospital room might have triggered the reduplicative delusion in this case.

Cited by 16 publications

References 19 publications

Misoplegia and dementia: a case study

Misoplegia and dementia: a case study

The delusion of the Master: the last days of Henry James

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

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