1988
DOI: 10.1016/0022-2836(88)90440-8
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Redundancy of information in enhancers as a principle of mammalian transcription control

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Cited by 63 publications
(29 citation statements)
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“…These results are reminiscent of those obtained with simian virus 40 (Zenke et al, 1986;Schaffner et al, 1988). It has been shown that the SV40 enhancer is composed of several regulatory elements, each with a distinct cell specificity (Schirm et al, 1987;Ondek et al, 1987).…”
Section: Discussionsupporting
confidence: 61%
“…These results are reminiscent of those obtained with simian virus 40 (Zenke et al, 1986;Schaffner et al, 1988). It has been shown that the SV40 enhancer is composed of several regulatory elements, each with a distinct cell specificity (Schirm et al, 1987;Ondek et al, 1987).…”
Section: Discussionsupporting
confidence: 61%
“…the proximal box C and site 824 oligonucleotides) could be compensated either by cooperative interactions through adjacent binding sites for POU factors or for other transcription factors (60,61) or by association of the POU proteins with a coactivator, as already described (62,63). The modular structure of enhancers has been reported as a general feature in higher eukaryotes (29,64,65). In the caase of aldolase C, another level of complexity could be brought by the fact that broad expression in the brain (5,6) could result from the additive effects of several cis-acting elements, each of them being specifically active in a restricted brain cell population.…”
Section: High Level Expression Of the Aldolase C Gene Requires The Prmentioning
confidence: 87%
“…At the C terminus of the largest subunit of mammalian RNA polymerase I1 the heptapeptide sequence of consensus Tyr-Ser-Pro-Thr-Ser-Pro-Ser is repeated 52 times. It was speculated that this repeated motif interacts with DNA-bound transcription factor(s) [204, 2051. If this turns out to be the case, it would mean that for the regulation of eukaryotic transcription, there is an information redundancy at three levels: at the level of DNA binding sites for transcription factors [206], presumably within the activating domains of transcription factors, and in the C-terminal repeats of the large subunit of RNA polymerase…”
Section: See One Transcriptionfactor and You Have Seen Them All?mentioning
confidence: 99%