Reductions of bacterial antibiotic resistance through five biological treatment processes treated municipal wastewater

Yuan, Qiuyan; Guo, Meiting; Wei, Wuji; Yang, Jian

doi:10.1007/s11356-016-7048-8

Cited by 54 publications

(16 citation statements)

References 47 publications

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“…Higher NH 4 + -N concentration was found to lead to lower removal of iARGs at the same chlorine dosage. Yuan et al (2016) reported that the purification of wastewater quality parameters (COD, NH + -N and turbidity) exhibited a positive correlation with ARB and ARGs reductions during the treatment in UWWTP. However, TN, TP and COD of influent, temperature and conductivity of mixed liquor were significant (p<0.05) correlated to multiple ARGs distribution in MBRs (Sun et al, 2016).…”

Section: Mmentioning

confidence: 97%

Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant

Liu¹,

Yang³

et al. 2018

Water Research

310

105

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The emergence and spread of antibiotic resistance has posed a major threat to both human health and environmental ecosystem. Although the disinfection has been proved to be efficient to control the occurrence of pathogens, little effort is dedicated to revealing potential impacts of disinfection on transmission of antibiotic resistance genes (ARGs), particularly for free-living ARGs in final disinfected effluent of urban wastewater treatment plants (UWWTP). Here, we investigated the effects of chlorine disinfection on the occurrence and concentration of both extracellular ARGs (eARGs) and intracellular ARGs (iARGs) in a full-scale UWWTP over a year. We reported that the concentrations of both eARGs and iARGs would be increased by the disinfection with chlorine dioxide (ClO). Specifically, chlorination preferentially increased the abundances of eARGs against macrolide (ermB), tetracycline (tetA, tetB and tetC), sulfonamide (sul1, sul2 and sul3), β-lactam (ampC), aminoglycosides (aph(2')-Id), rifampicin (katG) and vancomycin (vanA) up to 3.8 folds. Similarly, the abundances of iARGs were also increased up to 7.8 folds after chlorination. In terms of correlation analyses, the abundance of Escherichia coli before chlorination showed a strong positive correlation with the total eARG concentration, while lower temperature and higher ammonium concentration were assumed to be associated with the concentration of iARGs. This study suggests the chlorine disinfection could increase the abundances of both iARGs and eARGs, thereby posing risk of the dissemination of antibiotic resistance in environments.

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Section: Mmentioning

confidence: 97%

Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant

Liu¹,

Yang³

et al. 2018

Water Research

310

105

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“…Specific biological treatment processes are highly variable, from suspended floc growth in the case of standard activated sludge treatment to attached biofilm processes, and mixed aerobic and anaerobic stages for biological nutrient removal. Following primary treatment, the water still contains some raw-sewage associated bacteria and several field studies have been conducted tracking ARB and ARGs through various biological treatment processes [68,101,102]. General log removal value (LRV) of bacteria following biological treatment is typically around 1-log, while the specific effects on ARB and ARGs are relatively more varied, which may be reflective of the nature of the sewage, process performance, climatic and unknown factors.…”

Section: Treatment Technologies To Remove Arb and Argsmentioning

confidence: 99%

Reusing Treated Wastewater: Consideration of the Safety Aspects Associated with Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes

Hong

Julian

Pype

et al. 2018

Water

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As more countries engage in water reuse, either intended or de facto, there is an urgent need to more comprehensively evaluate resulting environmental and public health concerns. While antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are increasingly coming under the spotlight, as emerging contaminants, existing water reuse regulations and guidelines do not adequately address these concerns. This perspectives paper seeks to frame the various challenges that need to be resolved to identify meaningful and realistic target types and levels of antibiotic resistance benchmarks for water reuse. First, there is the need for standardized and agreed-upon methodologies to identify and quantify ARB and ARGs. Second, even if methodologies are available, identifying which ARB and ARGs to monitor that would best relate to the occurrence of disease burden remains unknown. Third, a framework tailored to assessing the risks associated with ARB and ARGs during reuse is urgently needed. Fourth, similar to protecting drinking water sources, strategies to prevent dissemination of ARB and ARGs via wastewater treatment and reuse are required to ensure that appropriate barriers are emplaced. Finally, current wastewater treatment technologies could benefit from modification or retrofit to more effectively remove ARB and ARGs while also producing a high quality product for water and resource recovery. This perspectives paper highlights the need to consider ARB and ARGs when evaluating the overall safety aspects of water reuse and ways by which this may be accomplished.

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“…The conditions in WWTPs, including the mixture of organisms from diverse environmental origins and the availability of surfaces and biofilms, can create strong selection pressures for resistance [ 8 , 17 ]. Even those treatments that are effective in removing bacteria from the water can promote the exchange, selection, and dispersal of genes involved in antibiotic resistance [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Localized effect of treated wastewater effluent on the resistome of an urban watershed

et al. 2020

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Background Wastewater treatment is an essential tool for maintaining water quality in urban environments. While the treatment of wastewater can remove most bacterial cells, some will inevitably survive treatment to be released into natural environments. Previous studies have investigated antibiotic resistance within wastewater treatment plants, but few studies have explored how a river’s complete set of antibiotic resistance genes (the “resistome") is affected by the release of treated effluent into surface waters. Results Here we used high-throughput, deep metagenomic sequencing to investigate the effect of treated wastewater effluent on the resistome of an urban river and the downstream distribution of effluent-associated antibiotic resistance genes and mobile genetic elements. Treated effluent release was found to be associated with increased abundance and diversity of antibiotic resistance genes and mobile genetic elements. The impact of wastewater discharge on the river’s resistome diminished with increasing distance from effluent discharge points. The resistome at river locations that were not immediately downstream from any wastewater discharge points was dominated by a single integron carrying genes associated with resistance to sulfonamides and quaternary ammonium compounds. Conclusions Our study documents variations in the resistome of an urban watershed from headwaters to a major confluence in an urban center. Greater abundances and diversity of antibiotic resistance genes are associated with human fecal contamination in river surface water, but the fecal contamination effect seems to be localized, with little measurable effect in downstream waters. The diverse composition of antibiotic resistance genes throughout the watershed suggests the influence of multiple environmental and biological factors.

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Reductions of bacterial antibiotic resistance through five biological treatment processes treated municipal wastewater

Cited by 54 publications

References 47 publications

Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant

Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant

Reusing Treated Wastewater: Consideration of the Safety Aspects Associated with Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes

Localized effect of treated wastewater effluent on the resistome of an urban watershed

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