2019
DOI: 10.1096/fj.201901936rr
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Reductions in skeletal muscle mitochondrial mass are not restored following exercise training in patients with chronic kidney disease

Abstract: Patients with chronic kidney disease (CKD) exhibit reduced exercise capacity, poor physical function and symptoms of fatigue. The mechanisms that contribute to this are not clearly defined but may involve reductions in mitochondrial function, mass and biogenesis. Here we report on the effect of non-dialysis dependent CKD (NDD-CKD) on mitochondrial mass and basal expression of transcription factors involved in mitochondrial biogenesis compared to a healthy control cohort (HC). In addition, we sought to investig… Show more

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Cited by 55 publications
(40 citation statements)
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References 67 publications
(197 reference statements)
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“…Previous studies have reported that mice and human with CKD displayed lower mitochondrial content/density in skeletal muscle (14,20,47,58), which contrast the observations herein. There are several biomarkers used to estimate mitochondrial content in muscle, however they vary widely in accuracy when compared to electron microscopy (a gold standard) (59).…”
Section: Discussioncontrasting
confidence: 99%
“…Previous studies have reported that mice and human with CKD displayed lower mitochondrial content/density in skeletal muscle (14,20,47,58), which contrast the observations herein. There are several biomarkers used to estimate mitochondrial content in muscle, however they vary widely in accuracy when compared to electron microscopy (a gold standard) (59).…”
Section: Discussioncontrasting
confidence: 99%
“…The underlying complex mechanisms of sarcopenia in the context of CKD are multifactorial. Whilst reductions in muscle strength are likely augmented by changes in muscle mass, the two are not exclusively related, and other detrimenta changes to muscle architecture, such as mitochondrial dysregulation 10,47 and motor neuron loss, may contribute 1 . In some individuals, sarcopenia is attributable to ageing (‘primary’ sarcopenia), 1 and unsurprisingly, we observed that older individuals were more likely to have probable sarcopenia, supporting previous research in CKD 12 .…”
Section: Discussionsupporting
confidence: 82%
“…These common symptoms were considered to be expressed in the pain/discomfort dimension of the EQ-5D-5L. Although this study showed a decrease in the mobility dimension, many studies [22][23][24][25][26][27] showed a relationship between muscle weakness and exercise capacity in hemodialysis patients, and it was considered a QOL characteristic.…”
Section: Discussionmentioning
confidence: 66%