Reductions in regional theta power and fronto-parietal theta-gamma phase-amplitude coupling during gaze processing in bipolar disorder

Lasagna, Carly A; Grove, Tyler B.; Semple, Erin; Suzuki, Takakuni; Menkes, Margo W.; Pamidighantam, Preetha; McInnis, Melvin G.; Deldin, Patricia; Tso, Ivy F.

doi:10.1016/j.pscychresns.2023.111629

Cited by 3 publications

(7 citation statements)

References 79 publications

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“…SZ also exhibited credible but modest increases in response caution relative to HC during gaze perception. This, in conjunction with inefficient evidence accumulation, impacted task performance, including slower and biased responding in SZ and slower, biased, and less accurate responding in BD found in previous studies of this data 16,17,20,21 . For SZ, heightened response caution functioned as a protective factor, offsetting their lower drift rates which in turn preserved their response accuracy at the expense of slower RTs.…”

Section: Discussionmentioning

confidence: 63%

“…The present study re-examined previously published datasets 16,17,20,21 consisting of 28 SZ, 38 BD, and 34 HC participating in two separate waves of a larger study examining social processing in SZ (“SZ sub-study” [28 SZ, 18 HC]) and BD (“BD sub-study” [38 BD, 16 HC]). Participants were recruited from the University of Michigan Prechter Bipolar Longitudinal Study, community advertisements, and local clinics.…”

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

“…Yet, in SZ and BD, these abilities are disrupted. Patients tend to make slower [16][17][18][19][20][21] , less accurate 17,20,22 , and/or less precise judgments about others' gaze [23][24][25][26][27] , and show self-referential biases toward over-endorsing eye contact [23][24][25][26]28,29,29,30 . These disruptions relate to poorer general 23,28,29 and social cognition 16,23,24,27,29 , and greater positive and negative symptoms (in SZ) 22,23,26,28 .…”

Section: Introductionmentioning

confidence: 99%

“…We leveraged extant data 16,17,20,21 to characterize cognitive processes driving gaze perception using a DDM framework 32 . We hypothesized that SZ and BD would show less efficient evidence accumulation than HC because patients exhibit lower drift rates across several cognitive tasks [33][34][35][36][37][38][39] .…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Mechanisms of Aberrant Self-Referential Social Perception in Psychosis and Bipolar Disorder: Insights from Computational Modeling

Lasagna,

Tso,

Blain

et al. 2024

Preprint

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Individuals with schizophrenia (SZ) and bipolar disorder (BD) show disruptions in self-referential gaze perception--a social perceptual process related to symptoms and functioning. However, our current mechanistic understanding of these dysfunctions and relationships is imprecise. The present study used mathematical modeling to uncover cognitive processes driving gaze perception abnormalities in SZ and BD, and how they relate to cognition, symptoms, and social functioning. We modeled the behavior of 28 SZ, 38 BD, and 34 controls (HC) in a self-referential gaze perception task using drift-diffusion models (DDM) parameterized to index key cognitive components: drift rate (evidence accumulation efficiency), drift bias (perceptual bias), start point (expectation bias), threshold separation (response caution), and non decision time (encoding/motor processes). Results revealed that aberrant gaze perception in SZ and BD was driven by less efficient evidence accumulation, perceptual biases predisposing self-referential responses, and greater caution (SZ only). Across SZ and HC, poorer social functioning was related to greater expectation biases. Within SZ, perceptual and expectancy biases were associated with hallucination and delusion severity, respectively. These findings indicate that diminished evidence accumulation and perceptual biases may underlie altered gaze perception in patients and that SZ may engage in compensatory cautiousness, sacrificing RT to preserve accuracy. Moreover, biases at the belief and perceptual levels may relate to symptoms and functioning. Computational modeling can, therefore, be used to achieve a more nuanced, cognitive process-level understanding of the mechanisms of social cognitive difficulties, like gaze perception, in individuals with SZ and BD.

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Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Mechanisms of Aberrant Self-Referential Social Perception in Psychosis and Bipolar Disorder: Insights from Computational Modeling

Lasagna,

Tso,

Blain

et al. 2024

Preprint

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Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

Yocum

Anderau

Bertram

et al. 2023

International Journal of Epidemiology

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Centering prayer in the treatment of bipolar disorder

Yanin Machado,

Mauricio Chinchilla,

Robert Hesse

et al. 2024

World J. Adv. Res. Rev.

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Bipolar Disorder (BD), formerly manic-depressive illness or manic depression, is a lifelong mood disorder and mental health condition that causes intense shifts in mood, energy levels, thinking patterns, and behavior. These shifts can last for hours, days, weeks, or months, interrupting the ability to carry out daily tasks. The condition is manageable with medications, talk therapy, lifestyle changes, and other treatments, but the therapy results are unreliable in many patients. Most faith traditions have two forms of prayer: discursive and contemplative. Most believers practice discursive prayer. Medical research has shown the statistical healing effects of discursive prayer, but there is considerably less research on contemplative prayer. Hesse reports a method of teaching CP by asking a volunteer to help demonstrate the analogy between human and Divine relationships in the following quoted phases., Therefore, we hypothesize that CP might produce a significant depression improvement in BP patients. Two neurologists double-blind diagnosed five patients complaining of BD and five normal subjects. All cases expressed their belief in God, so CP is prayer, not non-theistic meditation. Patients will be free of medication and selected during depressive episodes. Among the trait markers are frontal alpha asymmetry,55,56, and changes in frontal qEEG cordance. A very stable QEEG pattern, consisting of frontal alpha asymmetry, was observed in all five patients. Hence, this pattern was used to compare QEEG before and after CP. Our main result showed that the focal left frontal Alpha increment disappeared after CP. Conclusion: CP is a promising tool for treating depression, organizing the function interplay among brain networks that subserve Cognition-emotion interactions in the prefrontal cortex.

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Reductions in regional theta power and fronto-parietal theta-gamma phase-amplitude coupling during gaze processing in bipolar disorder

Cited by 3 publications

References 79 publications

Cognitive Mechanisms of Aberrant Self-Referential Social Perception in Psychosis and Bipolar Disorder: Insights from Computational Modeling

Cognitive Mechanisms of Aberrant Self-Referential Social Perception in Psychosis and Bipolar Disorder: Insights from Computational Modeling

Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

Centering prayer in the treatment of bipolar disorder

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