Reductions in overshoot during aspirin use

McFadden, Dennis; Champlin, Craig A.

doi:10.1121/1.399056

Cited by 47 publications

(30 citation statements)

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“…An advantage of the present experiments is the quantitative evaluation of processes in the auditory nerve, which were previously hypothesized to be related to overshoot (Champlin and McFadden 1989;McFadden and Champlin 1990;Bacon and Takahashi 1992), but were not rigorously tested. For example, the shallow slope of the short-delay function (open squares in Fig.…”

Section: The Medial Olivocochlear Reflex Hypothesismentioning

confidence: 99%

“…Diminished overshoot in listeners with temporary (Champlin and McFadden 1989;McFadden and Champlin 1990) or permanent cochlear hearing loss (Bacon and Takahashi 1992) has been hypothesized to be due to a reduction in the onset responses of AN fibers. This hypothesis assumes that CFR adaptation is altered following cochlear hearing loss in such a way that onset responses are reduced.…”

Section: Overshoot and Hearing Impairmentmentioning

confidence: 99%

“…This hypothesis is based on the prediction that a constant incremental response in the presence of adaptation should improve threshold by 3-5 dB (Smith and Zwislocki 1975). Furthermore, CFR adaptation has been hypothesized to account for the level dependence of overshoot based on differences in onset responses and thresholds of high and low spontaneous-rate (SR) fibers (McFadden and Champlin 1990).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Jennings

Heinz

Strickland

2011

JARO

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Masked detection threshold for a short tone in noise improves as the tone's onset is delayed from the masker's onset. This improvement, known as "overshoot," is maximal at mid-masker levels and is reduced by temporary and permanent cochlear hearing loss. Computational modeling was used in the present study to evaluate proposed physiological mechanisms of overshoot, including classic firing rate adaptation and medial olivocochlear (MOC) feedback, for both normal hearing and cochlear hearing loss conditions. These theories were tested using an established model of the auditory periphery and signal detection theory techniques. The influence of several analysis variables on predicted tone-pip detection in broadband noise was evaluated, including: auditory nerve fiber spontaneousrate (SR) pooling, range of characteristic frequencies, number of synapses per characteristic frequency, analysis window duration, and detection rule. The results revealed that overshoot similar to perceptual data in terms of both magnitude and level dependence could be predicted when the effects of MOC efferent feedback were included in the auditory nerve model. Conversely, simulations without MOC feedback effects never produced overshoot despite the model's ability to account for classic firing rate adaptation and dynamic range adaptation in auditory nerve responses. Cochlear hearing loss was predicted to reduce the size of overshoot only for model versions that included the effects of MOC efferent feedback. These findings suggest that overshoot in normal and hearing-impaired listeners is mediated by some form of dynamic range adaptation other than what is observed in the auditory nerve of anesthetized animals. Mechanisms for this adaptation may occur at several levels along the auditory pathway. Among these mechanisms, the MOC reflex may play a leading role.

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Section: The Medial Olivocochlear Reflex Hypothesismentioning

confidence: 99%

Section: Overshoot and Hearing Impairmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Jennings

Heinz

Strickland

2011

JARO

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“…This improvement, known as "overshoot," can be as large as 20 dB, depending on stimulus settings (Bacon and Smith, 1991) and the hearing status of the listener (Bacon and Takahashi, 1992). For example, overshoot is reduced in listeners with cochlear hearing loss (Bacon and Takahashi, 1992;Strickland and Krishnan, 2005) and in normal-hearing (NH) listeners who acquire a temporary cochlear hearing loss from aspirin ingestion (McFadden and Champlin, 1990) or intense noise exposure (Champlin and McFadden, 1989). The reduction in overshoot with permanent or temporary cochlear hearing loss suggests that overshoot is related to the status of the cochlear amplifier (von Klitzing and Kohlrausch, 1994).…”

Section: Introductionmentioning

confidence: 99%

Effects of age and hearing loss on overshoot

Jennings

Ahlstrom

Dubno

2016

The Journal of the Acoustical Society of America

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The detection of a brief, sinusoidal probe in a long broadband, simultaneous masker improves as the probe is delayed from the masker's onset. This improvement ("overshoot") may be mediated by a reduction in cochlear amplifier gain over the timecourse of the masker via the medial olivocochlear (MOC) reflex. Overshoot was measured in younger adults with normal hearing and in older adults with normal and impaired hearing to test the hypothesis that aging and cochlear hearing loss result in abnormal overshoot, consistent with changes in certain structures along the MOC pathway. Overshoot decreased with increasing quiet probe thresholds and was only minimally influenced by increasing age. Marked individual differences in overshoot were observed due to differences in masking thresholds for probes presented near the masker's onset. Model simulations support the interpretation that reduced overshoot in hearing-impaired listeners is due to limited cochlear amplifier gain and therefore less gain to adjust over the timecourse of the masker. Similar overshoot among younger and older adults with normal hearing suggests that age-related changes to mechanisms underlying overshoot do not result in significant differences in overshoot among younger and older adults with normal hearing.

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“…Cochlear damage tends to make the cochlea more linear, thus reducing (Carlyon and Sloan 1987) or removing the overshoot effect in hearing-impaired subjects (Bacon and Takahashi 1992). Temporary loss of cochlear nonlinearity as a result of temporary threshold shift (Champlin and McFadden 1989) or aspirin consumption also reduces or removes the overshoot effect in normal-hearing subjects (McFadden and Champlin 1990).…”

Section: Introductionmentioning

confidence: 99%

Temporal Masking in Electric Hearing

Zeng

Chen

Han

2005

JARO

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Temporal masking can be defined as the detection threshold of a brief signal as a function of the signal delay in a relatively long masker. The temporal masking pattern in normal acoustic hearing reveals temporal edge enhancement in which the signal detection threshold is greater near the masker onset than in the steady-state portion. Both peripheral and central mechanisms appear to underlie temporal edge enhancement, but their relative contributions remain elusive. Cochlear implants bypass cochlear mechanical processing and stimulate the auditory nerve directly, thereby providing a unique opportunity to separate the peripheral mechanisms from the central mechanisms. Here, we systematically measured temporal masking in electric hearing by examining whether a brief signal was harder to detect at the onset than in the steady-state portion of a long masker (the Bovershoot^effect). The signal and the masker were presented (1) either to the same electrode or to different electrodes, (2) at the same stimulation or different rates, and (3) in a simultaneous or an interleaved fashion. A consistent pattern of results was observed, depending on the stimulus configuration between the signal and the masker. Simultaneous stimulation at the same rate and with the same electrode produced no difference in sensitivity between the onset and the steady-state conditions, but interleaved stimulation at different rates or with different electrodes produced a significant difference. Unlike acoustic hearing, high masker levels produced an overshoot effect, and low masker levels produced an undershoot effect. Although the present results are consistent with the Bon-frequency vs. off-frequency^hypothesis for the overshoot effect, results also suggest a central Bsame vs. different^mechanism underlying temporal masking. These results have practical implications for improving cochlear implant design.

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Reductions in overshoot during aspirin use

Cited by 47 publications

References 0 publications

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Effects of age and hearing loss on overshoot

Temporal Masking in Electric Hearing

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