Reductions in GABA following a tDCS-language intervention for primary progressive aphasia

Harris, Ashley D.; Wang, Zeyi; Ficek, Bronte; Webster, Kim; Edden, Richard A.E.; Tsapkini, Kyrana

doi:10.1016/j.neurobiolaging.2019.03.011

Cited by 34 publications

(39 citation statements)

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“…The prolonged and promising changes in both cortical excitability and promising changes in behavioral outcomes combined with its simple application and low cost makes tDCS an attractive as a possible therapeutic tool for a range of clinical conditions [5]. For example, tDCS has been suggested to improve symptoms and/or assist in rehabilitation for many neurological disorders with minimal side effects [6], including migraine [7], stroke [8], Parkinson's disease [9], pain disorders [10] and neurodegenerative disorders [11], as well as psychiatric disorders including depression [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study

et al. 2020

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Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS), it has been shown that tDCS can affect local levels of γ-aminobutyric acid (GABA) and Glx (a measure of glutamate and glutamine combined) in adults, both of which are known to be associated with skill acquisition and plasticity; however this has yet to be studied in children and adolescents. This study examined GABA and Glx in response to conventional anodal tDCS (a-tDCS) and high definition tDCS (HD-tDCS) targeting the M1 in a pediatric population. Twenty-four typically developing, right-handed children ages 12-18 years participated in five consecutive days of tDCS intervention (sham, a-tDCS or HD-tDCS) targeting the right M1 while training in a fine motor task (Purdue Pegboard Task) with their left hand. Glx and GABA were measured before and after the protocol (at day 5 and 6 weeks) using a PRESS and GABA-edited MEGA-PRESS MRS sequence in the sensorimotor cortices. Glx measured in the left sensorimotor cortex was higher in the HD-tDCS group compared to a-tDCS and sham at 6 weeks (p = 0.001). No changes in GABA were observed in either sensorimotor cortex at any time. These results suggest that neither a-tDCS or HD-tDCS locally affect GABA and Glx in the developing brain and therefore it may demonstrate different responses in adults.

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Section: Introductionmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study

et al. 2020

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“…Non-invasive stimulation is an expanding area of research with investigations into the use of modalities similar to tDCS being investigated as a therapy for a range of disorders including migraine, pain and stroke (6,7,9,11,12,18,67). While these studies have suggested that noninvasive brain stimulation can improve outcomes, there is little analysis into the underlying physiological changes behind these responses are not well understood, particularly in the developing brain.…”

Section: Discussionmentioning

confidence: 99%

“…Adult literature using healthy controls suggests acute decrease in GABA local to the tDCS target (4,25,26,48). Similarly, participants with a neurodegenerative condition who followed a protocol of 15 a-tDCS sessions also showed decreased GABA in the tissue targeted with a-tDCS (11).…”

Section: Post-intervention Changes In Gaba and Glxmentioning

confidence: 92%

“…Persistent decreases in GABA several weeks after tDCS intervention have been seen in primary progressive aphasia (11); though those changes were seen at the site of stimulation. Several studies have shown improvement in motor learning in the contralateral hand following tDCS of either the right or left M1 (63-65).…”

Section: Week Follow Up In Gaba and Glxmentioning

confidence: 97%

“…The prolonged and promising changes in both cortical excitability and promising changes in behavioral outcomes combined with its simple application and low cost makes tDCS an attractive as a possible therapeutic tool for a range of clinical conditions (5). For example, tDCS has been suggested to improve symptoms and/or assist in rehabilitation for many neurological disorders with minimal side effects (6), including migraine (7), stroke (8), Parkinson's disease (9), pain disorders (10) and neurodegenerative disorders (11), as well as psychiatric disorders including depression (12).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Transcranial Direct Current Stimulation on GABA and Glutamate in Children: A Pilot Study

Nwaroh

Giuffre

Cole

et al. 2019

Preprint

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Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions.Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS) it has been shown that tDCS can affect local levels of -aminobutyric acid (GABA) and Glx (a measure of glutamate and glutamine combined) in adults, both of which are known to be associated with skill acquisition and plasticity; however this has yet to be studied in children and adolescents. This study examined GABA and Glx in response to conventional anodal tDCS (a-tDCS) and high definition tDCS (HD-tDCS) targeting the M1 in a pediatric population. Twenty-four typically developing, right handed children ages 12-18 years participated in five consecutive days of tDCS intervention (sham, a-tDCS or HD-tDCS) targeting the right M1 while training in a fine motor task (Purdue Pegboard Task) with their left hand. Glutamate and GABA were measured before and after the protocol (at day 5 and 6 weeks) using conventional MRS and GABA-edited MRS in the sensorimotor cortices.Glutamate measured in the left sensorimotor cortex was higher in the HD-tDCS group compared to a-tDCS and sham at 6 weeks (p = 0.001). No changes in GABA were observed in either sensorimotor cortex at any time. These results suggest that neither a-tDCS or HD-tDCS locally affect GABA and glutamate in the developing brain and therefore it may demonstrate different responses in adults.

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The developmental trajectory of functional excitation‐inhibition balance relates to language abilities in autistic and allistic children

Plueckebaum,

Meyer,

Beck

et al. 2023

Autism Research

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Autism is a neurodevelopmental condition that has been related to an overall imbalance between the brain's excitatory (E) and inhibitory (I) systems. Such an EI imbalance can lead to structural and functional cortical deviances and thus alter information processing in the brain, ultimately giving rise to autism traits. However, the developmental trajectory of EI imbalances across childhood and adolescence has not been investigated yet. Therefore, its relationship to autism traits is not well understood. In the present study, we determined a functional measure of the EI balance (f‐EIB) from resting‐state electrophysiological recordings for a final sample of 92 autistic children from 6 to 17 years of age and 100 allistic (i.e., non‐autistic) children matched by age, sex, and nonverbal‐IQ. We related the developmental trajectory of f‐EIB to behavioral assessments of autism traits as well as language ability. Our results revealed differential EI trajectories for autistic compared to allistic children. Importantly, the developmental trajectory of f‐EIB values related to individual language ability. In particular, elevated excitability in late childhood and early adolescence was linked to decreased listening comprehension. Our findings provide evidence against a general EI imbalance in autistic children when correcting for non‐verbal IQ. Instead, we show that the developmental trajectory of EI balance shares variance with autism trait development at a specific age range. This is consistent with the proposal that the late development of inhibitory brain activity is a key substrate of autism traits.

show abstract

Reductions in GABA following a tDCS-language intervention for primary progressive aphasia

Cited by 34 publications

References 50 publications

Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study

Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study

Effects of Transcranial Direct Current Stimulation on GABA and Glutamate in Children: A Pilot Study

The developmental trajectory of functional excitation‐inhibition balance relates to language abilities in autistic and allistic children

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