Reduction-responsive diblock copolymer-modified gold nanorods for enhanced cellular uptake

Li, Yixia; Si, Jianhao; Fan, Haiyan; Yang, Jinxian; Ye, Xiaodong

doi:10.1039/c8ra03545h

Cited by 8 publications

(5 citation statements)

References 56 publications

(64 reference statements)

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“…Lipoic acid was selected as an aurophilic ligand that can covalently bind the surface of AuNPs. In particular, it was selected for its disulfide-containing dithiolane ring, which is known to break open in the presence of an Au(0) gold surface and bind in a robust bidentate manner, − thus affording stable nanorings.…”

Section: Results and Discussionmentioning

confidence: 73%

Biomolecular Self-Assembly of Nanorings on a Viral Protein Template

et al. 2022

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Although there have been many advances in synthesizing nanoparticles, their assembly into deterministic and controllable patterns remains a major challenge. Biological systems operate at the nanoscale, building structural components with great chemical specificity that enable the processes of life. By adapting them to our needs, it is possible to utilize well-defined and wellcontrolled scaffolds to produce materials with novel properties resulting from precise ordering on the nanoscale. This approach uses spatial arrangement instead of nanoparticle size, shape, or composition to control material properties through the collective interactions between neighboring nanoparticles. Here, we demonstrate the use of tobacco mosaic virus (TMV) coat protein as a template to self-assemble plasmonic nanoparticles. Surface plasmons are resonant oscillations in the free electrons of a metal that are excited through interaction with light. These plasmonic oscillations can couple together, giving rise to more complex modes like plasmonic ring resonances that can be used to tune the response to incident light. By exploiting the self-assembling properties and chemical addressability of TMV coat protein, we can utilize sitedirected mutagenesis and bioconjugation strategies to produce highly symmetrical plasmonic nanorings, as evidenced by transmission electron microscopy (TEM). Thus, we show the utility of viral proteins in designing and assembling nanostructured building blocks for advanced materials.

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Section: Results and Discussionmentioning

confidence: 73%

Biomolecular Self-Assembly of Nanorings on a Viral Protein Template

et al. 2022

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“…AuNRs@HA‐g‐(mPEG/Teta‐co‐LA/TCPP/FA) nanoplatform was prepared by forming stable Au‐S bonds between LA and AuNRs based on previously reported (Y. Li et al, 2018; Wang et al, 2018). The successful capping of HA‐g‐(mPEG/Teta‐co‐LA/TCPP/FA) polymer ligand onto the surface of AuNRs@CTAB was verified by measurements of zeta‐potential, HR‐TEM, and UV‐vis spectroscopy.…”

Section: Resultsmentioning

confidence: 99%

Dual‐targeting multifunctional hyaluronic acid ligand‐capped gold nanorods with enhanced endo‐lysosomal escape ability for synergetic photodynamic–photothermal therapy of cancer

et al. 2023

Biotech & Bioengineering

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Au nanorods (AuNRs) have attracted considerable interest as drug delivery systems because of their enhanced cell internalization and stronger drug-loading ability. In addition, the incorporation of photodynamic therapy (PDT) and photothermal therapy (PTT) into one nanosystem presents great promise to defect multiple drawbacks in cancer therapy. Herein, we fabricated a multifunctional and dual-targeting nanoplatform based on hyaluronic acid-grafted-(mPEG/triethylenetetramine-conjugated-lipoic acid/ tetra(4-carboxyphenyl)porphyrin/folic acid) polymer ligand capped AuNRs (AuNRs@HAg-(mPEG/Teta-co-(LA/TCPP/FA)) for combined photodynamic-photothermal therapy of cancer. The prepared nanoparticles displayed high TCPP loading capacity and excellent stability in different biological media. Furthermore, AuNRs@HA-g-(mPEG/Teta-co-(LA/ TCPP/FA)) not only could produce a localized hyperthermia to conduct PTT, but also generate cytotoxic singlet oxygen ( 1 O 2 ) to perform PDT under laser irradiation. Confocal imaging results disclosed that this nanoparticle endowing the specific function of polymeric ligand could enhance cellular uptake, accelerate endo/lysosomal escape, as well as produce higher reactive oxygen species. Importantly, this combination therapy strategy could also induce higher anticancer potential than PDT or PTT only against MCF-7 tumor cells in vitro. Therefore, this work presented an AuNRs-based therapeutic nanoplatform with great potential in dual-targeting and photo-induced combination therapy of cancer.

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“…The AuNRs@HA-mPEG-Deta-LA nanoplatform was developed through the formation of stable Au-S bonds between LA and AuNRs. 46,47 This construction allows for the creation of a tumor-targeting, enzyme-responsive, and highly efficient NIRtriggered photothermal therapy (PTT) nanoplatform. The successful incorporation of the polymer ligand HA-mPEG-Deta-LA onto the surface of AuNRs@CTAB was confirmed through zetapotential measurements, HR-TEM imaging, and UV-vis spectroscopy.…”

Section: Construction and Analysis Of The Aunrs@ha-mpeg-deta-la Nanop...mentioning

confidence: 99%

A tumor-targeted and enzyme-responsive gold nanorod-based nanoplatform with facilitated endo–lysosomal escape for synergetic photothermal therapy and protein therapy

Wang,

Xu,

et al. 2024

Dalton Trans.

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Reduction-responsive diblock copolymer-modified gold nanorods for enhanced cellular uptake

Abstract: Gold nanorod (AuNRs) modified by reduction-responsive amphiphilic copolymer poly(ε-caprolactone)-b-poly[(oligoethylene glycol)acrylate] (LA–PCL–SS–POEGA) can enhance the cellular uptake of AuNRs, presumably due to the aggregation under reducing environment in the cells.

Cited by 8 publications

References 56 publications

Biomolecular Self-Assembly of Nanorings on a Viral Protein Template

Biomolecular Self-Assembly of Nanorings on a Viral Protein Template

Dual‐targeting multifunctional hyaluronic acid ligand‐capped gold nanorods with enhanced endo‐lysosomal escape ability for synergetic photodynamic–photothermal therapy of cancer

A tumor-targeted and enzyme-responsive gold nanorod-based nanoplatform with facilitated endo–lysosomal escape for synergetic photothermal therapy and protein therapy

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