Reduction-Responsive Chemo-Capsule-Based Prodrug Nanogel for Synergistic Treatment of Tumor Chemotherapy

Lu, Yi; Jia, Die; Ma, Xianbin; Liang, Mengyun; Hou, Shengxin; Qiu, Wei; Gao, Yuan; Xue, Peng; Kang, Yuejun; Xu, Zhigang

doi:10.1021/acsami.0c21710

Cited by 41 publications

(30 citation statements)

References 54 publications

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“…The reductive agent glutathione was the factor responsible for releasing the drug effectively (Figure 5C,D). The studies and results show that the combined effects of 10-hydroxy camptothecin (HCPT) and doxorubicin (DOX) contribute to the apoptosis process through the topoisomerase pathway, which improves the inhibitory effect in tumor growth [122]. (Reproduced with the permission from ref.…”

Section: Functionalized Role Of Nanohydrogelsmentioning

confidence: 99%

Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Quazi

Park

2022

IJMS

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In the era of nanotechnology, the synthesis of nanomaterials for advanced applications has grown enormously. Effective therapeutics and functionalization of effective drugs using nano-vehicles are considered highly productive and selectively necessary. Polymeric nanomaterials have shown their impact and influential role in this process. Polymeric nanomaterials in molecular science are well facilitated due to their low cytotoxic behavior, robust functionalization, and practical approach towards in vitro and in vivo therapeutics. This review highlights a brief discussion on recent techniques used in nanohydrogel designs, biomedical applications, and the applied role of nanohydrogels in the construction of advanced therapeutics. We reviewed recent studies on nanohydrogels for their wide applications in building strategies for advantageously controlled biological applications. The classification of polymers is based on their sources of origin. Nanohydrogel studies are based on their polymeric types and their endorsed utilization for reported applications. Nanotechnology has developed significantly in the past decades. The novel and active role of nano biomaterials with amplified aspects are consistently being studied to minimize the deleterious practices and side effects. Here, we put forth challenges and discuss the outlook regarding the role of nanohydrogels, with future perspectives on delivering constructive strategies and overcoming the critical objectives in nanotherapeutic systems.

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Section: Functionalized Role Of Nanohydrogelsmentioning

confidence: 99%

Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Quazi

Park

2022

IJMS

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“…In another study, the in vivo synergistic antitumor efficiency of HSD NGs was assessed in 4T1 tumor-bearing mice, and results indicated that HSD NGs enhanced apoptosis and tumor accumulation, and suppressed tumor growth and volume [ 68 ].…”

Section: Anticancer Activities Of Camptothecin Nano-formulationsmentioning

confidence: 99%

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review

Ghanbari-Movahed

Kaceli

Mondal³

et al. 2021

Biomedicines

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Camptothecin (CPT), a natural plant alkaloid, has indicated potent antitumor activities via targeting intracellular topoisomerase I. The promise that CPT holds in therapies is restricted through factors that include lactone ring instability and water insolubility, which limits the drug oral solubility and bioavailability in blood plasma. Novel strategies involving CPT pharmacological and low doses combined with nanoparticles have indicated potent anticancer activity in vitro and in vivo. This systematic review aims to provide a comprehensive and critical evaluation of the anticancer ability of nano-CPT in various cancers as a novel and more efficient natural compound for drug development. Studies were identified through systematic searches of PubMed, Scopus, and ScienceDirect. Eligibility checks were performed based on predefined selection criteria. Eighty-two papers were included in this systematic review. There was strong evidence for the association between antitumor activity and CPT treatment. Furthermore, studies indicated that CPT nano-formulations have higher antitumor activity in comparison to free CPT, which results in enhanced efficacy for cancer treatment. The results of our study indicate that CPT nano-formulations are a potent candidate for cancer treatment and may provide further support for the clinical application of natural antitumor agents with passive targeting of tumors in the future.

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“…According to research data, the concentration of GSH in tumor cells reaches 2-10 mM, while the concentration in normal tissues is merely around 2-20 μM (Yuan et al, 2018;Kumar et al, 2019). Based on this, Lu developed a two-in-one cross-linking strategy to prepare GSH-responsive prodrug nanogels by coupling DOX and CPT using disulfide compound as crosslinker agent (Lu et al, 2021). Under the high concentration of GSH in tumor, both DOX and CPT released about 75% within 48 h in physiological pH 7.4.…”

Section: Redox-sensitive Nanogelsmentioning

confidence: 99%

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Gao

Kang

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, the exploration of tumor microenvironment has provided a new approach for tumor treatment. More and more researches are devoted to designing tumor microenvironment-responsive nanogels loaded with therapeutic drugs. Compared with other drug carriers, nanogel has shown great potential in improving the effect of chemotherapy, which is attributed to its stable size, superior hydrophilicity, excellent biocompatibility, and responsiveness to specific environment. This review primarily summarizes the common preparation techniques of nanogels (such as free radical polymerization, covalent cross-linking, and physical self-assembly) and loading ways of drug in nanogels (including physical encapsulation and chemical coupling) as well as the controlled drug release behaviors. Furthermore, the difficulties and prospects of nanogels as drug carriers are also briefly described.

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Reduction-Responsive Chemo-Capsule-Based Prodrug Nanogel for Synergistic Treatment of Tumor Chemotherapy

Cited by 41 publications

References 54 publications

Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

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