Reduction of TNFα expression by Chungkookjang extracts in human breast cancer MDA-MB-231 cells

Abstract

Chungkookjang, fermented soybeans, contains diverse peptides produced during fermentation. Fermented soybean extracts containing the peptides can affect cellular signal transduction. Proliferation of human breast cancer MDA-MB-231 cells were repressed dependent on concentrations of fermented soybean extracts. Since fermented soybean extracts inhibited breast cancer cell's growth, and inflammation is related to cancer, it is determined whether it can suppress inflammatory TNFα expression. TNFα expression in MDA-MB 231 cells treated with fermented soybean extracts was repressed by that extracts. TNFα inhibitors were developed as drugs for autoimmune diseases. Since fermented soybean extracts suppressed TNFα expression, it can be developed as those drugs.