Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine–ketamine in combination with either morphine or fentanyl

Aguado, Delia; Benito, Javier; Segura, Ignacio A. Gómez de

doi:10.1016/j.tvjl.2010.05.029

Cited by 58 publications

(57 citation statements)

References 31 publications

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“…Although this is not the supramaximal noxious stimulus for dogs compared to electrical stimulation or clamping of the tail, it is a reliable method because it mimics the clinical situation. Aguado et al (2011), using the same method, found lower isoflurane MAC than that reported by Muir et al (2003), using the same doses of lidocaine, ketamine and morphine, but the proportional MAC reductions were similar. Four crossovers were considered adequate for MAC estimation as it is reported that the MAC values obtained from four crossovers is nearly the same as the MAC values obtained from a larger number of crossovers (Paul & Fisher 2001).…”

Section: Discussionsupporting

confidence: 62%

“…Changes in the response to pain stimuli between two consecutive animalsa positive response followed by a negative response, or vice versa -were defined as crossover values. The ETsevo tested in four crossovers, in which the same dog could not appear twice (ETsevo values from eight different dogs), were used to calculate the MACsevo value in each group by mathematical averaging (Aguado et al 2011, Wadhwa et al 2003.…”

Section: Methodsmentioning

confidence: 99%

“…This effect may be increased by adding an opioid, as they are capable of promoting sedation in addition to being potent analgesics (Koppert 2004). Studies have shown that the combination of ketamine, lidocaine along with morphine or fentanyl in a continuous infusion decreased the minimum alveolar concentration (MAC) of inhalational anesthetic agents in horses (Muir 2010, Villalba et al 2011) and dogs (Wilson et al 2008, Aguado et al 2011.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of continuous intravenous infusion of tramadol and tramadol-lidocaine-ketamine in the sevoflurane requirement in dogs

et al. 2017

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RESUMO.-[Comparação da infusão continua intravenosa de tramadol e de tramadol-lidocaína-cetamina no requerimento de sevofluorano em cães.] O objetivodeste estudo foi comparar a influência da infusão contínua intravenosa do tramadol isolado e associado com lidocaína e cetamina, na concentração alveolar mínima de sevofluorano (CAMsevo) em cadelas submetidas à ovariosalpingohisterectomia. Foram utilizados 28 animais saudáveis de várias raças e idades, divididos aleatoriamente em dois grupos de acordo com a infusão adminstrada: TRA (tramadol) ou TLK (tramadol, lidocaína e cetamina). A medicação pré-anestésica foi realizada com acepromazina e midazolam, em seguida, a anestesia foi induzida com propofol e mantida com sevofluorano. Quinze minutos após a indução, os pacientes receberam um bolus do tratamento, com a infusão continua iniciada logo em seguida, sendo 1,3mg/kg/ hora de tramadol, associado ou não a 3mg/kg/hora de lidocaína e 0,6mg/kg/hora de cetamina, diluidos em uma bolsa The objective of this study was to compare the influence of continuous intravenous infusion of tramadol alone, or tramadol combined with lidocaine and ketamine, on minimum alveolar concentration of sevoflurane (MACsevo) of dogs undergoing an ovariohysterectomy (OHE). We used 28 healthy dogs of various breeds and age, randomly divided into two groups according to the infusion given: TRA (tramadol alone) or TLK (tramadol, lidocaine and ketamine). The patients were premedicated with acepromazine and midazolam, and then anesthesia was induced with propofol and maintained with sevoflurane. Fifteen minutes after induction, the patients received their loading dose of treatment. Then, the continuous infusion was then set to 1.3mg/kg/hour of tramadol with or without 3mg/kg/ hour of lidocaine and 0.6mg/kg/hour of ketamine, diluted in a 500mL bag of saline solution at an infusion rate of 10mL/kg/hour. The Dixon method was chosen to determine the MACsevo and a skin incision was used as a noxious stimulus. An unpaired Student's t-test was used to identify statistically significant differences between the treatments. These differences were considered significant when p<0.05. The MACsevo of the TRA group was 1.22±0.15 vol% and the MACsevo of the TLK group was 0.85±0.22 vol%. We conclude that TLK infusion decreased the MACsevo by 30.22% compared to tramadol alone, demonstrating that the combination of drugs was effective in reducing MACsevo in dogs.INDEX TERMS: Tramadol, tramadol-lidocaine-ketamine, sevoflurane, dogs, analgesia, anesthesia, inhalant, MAC.

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Section: Discussionsupporting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of continuous intravenous infusion of tramadol and tramadol-lidocaine-ketamine in the sevoflurane requirement in dogs

et al. 2017

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“…Morphine has been used to provide analgesia/antinociception in dogs (MURPHY & HUG, 1992;KO et al, 2009;AGUADO et al, 2011;MONTEIRO et al, 2016). As with other µ-opioid agonists, morphine decreased the minimum alveolar concentration (MAC) of enflurane in a dose-related manner in dogs (MURPHY & HUG, 1992).…”

mentioning

confidence: 99%

“…The ISO MAC was determined by the upand-down method as reported in previous studies in dogs (AGUADO et al, 2011;MONTEIRO et al, 2016). The ETiso for the first dog in each group was set at 0.8%.…”

mentioning

confidence: 99%

Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

et al. 2017

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This study aimed to evaluate the effects of intramuscular 0.5mg kg-1 (MOR0.5) and 1.0mg kg-1 (MOR1.0) morphine premedication on the minimum alveolar concentration of isoflurane (ISOMAC) in dogs. Eighteen client-owned female dogs were scheduled for elective ovariohysterectomy. Dogs received intramuscular MOR0.5 or MOR1.0 as premedication and propofol IV for induction of anesthesia. Isoflurane was delivered for maintenance of anesthesia and dogs were maintained under normocapnia and normothermia. Determinations of the ISOMAC were conducted by use of the “up-and-down” method. Noxious stimulus (placement of Backhaus towel clamps, a midline skin incision and subcutaneous tissue dissection) was delivered approximately 50 minutes after premedication with MOR0.5 or MOR1.0. The calculated ISOMAC was 0.98±0.15% in MOR0.5 and 0.80±0.08% in MOR1.0. The ISOMAC was significantly lower in MOR1.0 compared with MOR0.5 (P=0.010). Results of this study suggested that intramuscular premedication with morphine 0.5 and 1.0mg kg-1 decreases the ISOMAC in a dose-related manner in dogs.

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Neoplastic Disease

Salazar

2014

Canine and Feline Anesthesia and Co‐Existing Disease

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Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine–ketamine in combination with either morphine or fentanyl

Cited by 58 publications

References 31 publications

Comparison of continuous intravenous infusion of tramadol and tramadol-lidocaine-ketamine in the sevoflurane requirement in dogs

Comparison of continuous intravenous infusion of tramadol and tramadol-lidocaine-ketamine in the sevoflurane requirement in dogs

Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

Neoplastic Disease

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