Reduction of Streptococcus mutans by probiotic milk: a multicenter randomized controlled trial

Manmontri, Chanika; Nirunsittirat, Areerat; Piwat, Supatcharin; Wattanarat, Onnida; Pahumunto, Nuntiya; Makeudom, Anupong; Sastraruji, Thanapat; Krisanaprakornkit, Suttichai; Teanpaisan, Rawee

doi:10.1007/s00784-019-03095-5

Cited by 28 publications

(32 citation statements)

References 32 publications

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“…Lactobacillus rhamnosus GG (ATCC 53103) [20][21][22][23], hct 70 [24], LB21 [25], LC 705 [22] reuteri ATCC 55,730 (SD2112) [26][27][28], ATCC PTA 5289 [29][30][31][32], DSM 17,938 [29][30][31][32] casei Shirota [33] paracasei F19 [34], GMNL-33 [35], SD1 [36][37][38] achidophilus ATCC 4356 [39], La-5 [40] salivarius TI 2711 [41], WB21 [41] brevis CD2 [42] bifidum [43] bulgaricus [43] sporogens [43] thermophilus [43] Bifidobacterium animalis lactis BB-12 (ATCC 27536) [40,[44][45][46], DN-173010 [47,48] bifidum ATCC 29,521 [39] longum [49] Streptococci mutans A2JM [50] rattus JH145 TM [51,52] oralis KJ3 TM [52] uberis KJ2 TM [52] dentisani CECT7746…”

Section: Genus Species Strainmentioning

confidence: 99%

“…More recent studies suggest that L. rhamnosus combined with B. longum, L. paracasei SD1, and L. brevis CD2 could also assist in attenuating the range of dental caries from early ages [37,38,42,49]. More specifically, L. rhamnosus combined with B. longum, despite being incapable of reducing S. mutans salivary levels, they do so as far as Lactobacilli are concerned and enhance the buffering capacity of saliva [49].…”

Section: Clinical Considerations On Probiotics' Effectivenessmentioning

confidence: 99%

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Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

et al. 2021

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Probiotic therapy forms a new strategy for dental caries prevention. Probiotic microorganisms possess the ability to displace cariogenic microorganisms and colonize the oral cavity. They can produce various antimicrobial substances such as bacteriocins, bacteriocin-like peptides, lactic acid, and hydrogen peroxide. Dairy products may be ideal for probiotic administration in dental patients. Many other means have been proposed, primarily for those allergic to dairy components, such as capsules, liquid form, tablets, drops, lozenges, sweetened cakes, and ice creams. The last two forms can be used in a coaching approach for children and elderly patients who find it difficult to avoid sugary beverages in their daily routine and benefit from the suggestion of easy, cheap, and common forms of delicacies. In caries prevention, the concept of the effector strain is already considered an integral part of the contemporary caries cure or prevention strategy in adults. Adults, though, seem not to be favored as much as children at early ages by using probiotics primarily due to their oral microbiome’s stability. In this non-systematic review we describe the modes of action of probiotics, their use in the cariology field, their clinical potential, and propose options to prevent caries through a patient coaching approach for the daily dental practice.

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Section: Genus Species Strainmentioning

confidence: 99%

Section: Clinical Considerations On Probiotics' Effectivenessmentioning

confidence: 99%

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

et al. 2021

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“…Regarding Lactobacillus acidophilus, Tahmourespour et al (2011) and Jothika et al (2015), clarify that its presence can cause a reduction in the adherence of streptococcal strains, mainly S. mutans [29,31]. In our review, L. paracasei was the most widely used probiotic; and in the trial by Manmontri et al (2020), this probiotic species reduces the number of cariogenic bacteria such as S. mutans in both saliva and dental plaque, and its reduction effect persists for at least 6 months after the discontinuation of the probiotic, this may be a consequence of the constant microbial modulation of L. paracasei SD1 and its ability to adhere to the epithelial cells of the oral mucosa [10]. In addition, other studies attribute the highest antimicrobial activity to L. paracasei, Lactobacillus plantarum, L. rhamnosus and L. salivarius, with L. paracasei being one of the commensal species of the genus Lactobacillus that has shown maximum interference activity against S. mutans, even in vitro [15].…”

Section: Discussionmentioning

confidence: 86%

“…Early childhood caries increases the risk of tooth decay in permanent teeth; it is also associated with a 3-7 month delay in the development of permanent teeth and its late maturation affects occlusion and can lead to problems with eating, speech, appearance, and behaviour [5][6][7]. This is a multifactorial disease; however, the main causal agent is represented by pathogenic acidic/aciduric microorganisms such as Streptococcus mutans, accompanied by dysbiosis in the oral cavity [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Oral Biofilm and Immune Response Associated to Mucosa with Probiotic Bacteria as a Potential Approach in the Prevention of Dental Caries: A Systematic Review

Ayala¹,

Zambrano²,

Vire³

et al. 2020

DOBCR

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Background: A variety of approaches have been developed for the control of dental caries, a pathology with high incidence and prevalence worldwide. The use of probiotic strains for the modulation of dental biofilm in the prevention of caries has been studied, but the available evidence shows varied methodologies; and the strains tested differ from one study to another. Objective: To analyse through a systematic review of clinical trials, the efficacy of using probiotic strains to prevent dental caries. Methods: A search was made in the scientific bases PubMed, Cochrane and Science Direct, prioritizing randomized double and triple-blind clinical trials from 2010 to 2020, including a total of 20 studies to be analysed. The selection criteria were consistent with the Preferred Reporting Items for Systematic Reviews protocol. Results: Within the studies, different types of probiotic bacteria were analysed, dominating Lactobacillus Paracasei. While most clinical trials show a favorable response in terms of a significant reduction of Streptococcus mutans in the oral microbiota, very few studies evaluated salivary pH and sIgA levels. Conclusion: The heterogeneity of the studies analysed and the multifactorial nature of dental caries do not allow us to ensure that probiotic therapy is completely effective in preventing this pathology. Although probiotic therapy can help by regulating the microbiological factor, there are other determinants that can favor the development of caries and that are barely approached in their relationship with bacteriotherapy. Future studies that homogeneously evaluate the use of probiotics could give us a clearer idea of their effectiveness.

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“…The daily and triweekly consumption of probiotic milk containing L. paracasei SD1 on Streptococcus mutans and lactobacilli counts in saliva and plaque samples was evaluated in preschool children for 6 months [79]. Probiotic administration reduced S. mutans counts and increased total lactobacilli counts in the saliva and plaque samples that persisted at least 6 months after discontinuation.…”

Section: Probiotics In Cariologymentioning

confidence: 99%

Probiotics in Oral Health and Disease: A Systematic Review

Saïz¹,

Taveira²,

Alves³

2021

Applied Sciences

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Purpose: Probiotics may exclude or antagonize oral pathogens and be useful to prevent oral dysbiosis and treat oral diseases. The objective of this review was to assess the benefits of probiotics in oral health and disease, and in dental practice; Methods: Primary articles published between January 2012 and 30 December 2020 with full text available were searched in PubMed, ClinicalTrials.gov, ScienceDirect, Google Scholar, B-on, and SciELO; Results: The electronic search identified 361 references of which 91 (25.2%) met all the inclusion criteria. In total, data from 5374 participants with gingivitis, periodontitis, peri-implantitis, caries, orthodontic conditions, halitosis, or oral conditions associated with chemo-radiotherapy were included. Despite major inconsistencies between clinical trials, probiotics have been found to contribute to reduce S. mutans counts (L. paracasei SD1), reduce probing depth in chronic periodontitis (B. animalis subsp. lactis DN-173010 with L. reuteri), reduce levels of volatile sulfur compounds and halitosis (L. salivarius WB21), treat oral mucositis and improve the quality of life of patients undergoing cancer chemo-radiotherapy (L. brevis CD2). Combinations of probiotic bacteria tend to lead to higher clinical efficacy than any individual probiotic agent; Conclusion: Oral probiotics influence favorably the oral microbiota and provide benefits to the oral ecosystem in periodontal diseases, cariology, halitosis, orthodontics and management of oral mucositis resulting from cancer treatment. However, the use of probiotics in dental practice or in self-management preventive strategies requires additional well controlled clinical trials to determine the most effective probiotic combinations, the most appropriate probiotic vehicle, and the frequency of administration.

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Reduction of Streptococcus mutans by probiotic milk: a multicenter randomized controlled trial

Cited by 28 publications

References 32 publications

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

Modulation of Oral Biofilm and Immune Response Associated to Mucosa with Probiotic Bacteria as a Potential Approach in the Prevention of Dental Caries: A Systematic Review

Probiotics in Oral Health and Disease: A Systematic Review

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