Reduction of spermatogenesis in mice after tributyltin administration

Chen, Yu‐Fang; Zuo, Zhenghong; Chen, Shuzhen; Yan, Feihuang; Chen, Yixin; Yang, Zeng‐Ming; Wang, Chonggang

doi:10.1016/j.tox.2008.06.015

Cited by 39 publications

(41 citation statements)

References 60 publications

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“…Under normal conditions, Sertoli cells are involved in the phagocytosis of discarded residual bodies and germ cells that degenerate in the normal course of spermatogenesis as well as in clearing up apoptotic germ cells (Russell et al, 1990). The proliferation of Sertoli cells found in this study could be interpreted as an increased need to clear the degenerated germ cells, as a result of the adverse effect of some deleterious agent such as organotins, heavy metals or estrogenic compounds (Chen et al, 2008;Dyer, 2007;Miles-Richardson et al, 1999a,b). GSI of females was very similar in all stations except from stations NJ, MJ and MR where the lowest values of GSI were recorded.…”

Section: Discussionmentioning

confidence: 59%

Gonadosomatic index and gonad histopathology of Gobius niger (Gobiidea, Teleost) from Bizerta lagoon (Tunisia): Evidence of reproduction disturbance

Louiz

Ben‐Attia²,

Ben-Hassine

2009

Fisheries Research

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Section: Discussionmentioning

confidence: 59%

Gonadosomatic index and gonad histopathology of Gobius niger (Gobiidea, Teleost) from Bizerta lagoon (Tunisia): Evidence of reproduction disturbance

Louiz

Ben‐Attia²,

Ben-Hassine

2009

Fisheries Research

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“…The number of cells in the seminiferous tubules is determined by a dynamic balance between cells proliferation and apoptotic cell death. Any imbalance of the two processes may result in histological changes in the seminiferous epithelium [47], including the increased number of multinucleated giant cells.…”

Section: Discussionmentioning

confidence: 99%

Testis morphology in rats chronically treated with letrozole, an aromatase inhibitor

Kondarewicz¹,

Kolasa²,

Zawiślak³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:The aim of this study was to investigate the influence of the long-term treatment of rats with letrozole on the testis morphology. The pharmacologically induced estrogen deficiency caused statistically significant decreases of both intratesticular and serum levels of estradiol, and morphological changes in the seminiferous epithelium and in the interstitial tissue of the testes. Six months of treatment resulted in the sloughing of premature germ cells of the seminiferous epithelium into the tubular lumen and in intraepithelial vacuolization. Multinucleated giant cells composed of premature germ cells, conglomerates of various cell nuclei and cell debris as well as irregularities and infoldings of the tubular basement membrane were also seen. Moreover, deep invaginations of the lamina propria with myoid cells were observed. Cells in the interstitial tissue showed changes similar to that observed in aging processes. The cytoplasm of LH-R-positive Leydig cells was loaded with lipofuscin granules. The number of lipofuscin-loaded cells was significantly increased in the interstitial tissue of testis in letrozole-treated rats. The results indicate the direct influence of estrogens on seminiferous tubules and the interstitial tissue morphology.

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“…Immature male mice receiving a single dose of TBT presented a delay in lumen formation in seminiferous tubules and increased numbers of apoptotic germ cells inside the tubules, but not in Leydig cells (40). Reduced serum testosterone levels (16,40,43,44) and down-regulated expression of P450scc (cholesterol side-chain cleavage enzyme complex), P450 (for example, 17α-hydroxylase), 3β-HSD and 17β-HSD were also observed (38). However, in contrast, another study reported an increase of serum testosterone (21).…”

Section: Male Reproductive Systemmentioning

confidence: 95%

“…Several studies addressing the effect of TBT on male reproductive functions have been reported (16,21,(37)(38)(39)(40)(41)(42)(43)(44). A study conducted on male rats over two generations showed that testis, epididymis, ventral prostate, and body weight decreased in all groups, but mainly in the group treated with a dietary concentration of 125 mg TBTCl per g diet (21).…”

Section: Male Reproductive Systemmentioning

confidence: 99%

Triorganotin as a compound with potential reproductive toxicity in mammals

Filho

Lopes

Podratz

et al. 2011

Braz J Med Biol Res

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Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

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Reduction of spermatogenesis in mice after tributyltin administration

Cited by 39 publications

References 60 publications

Gonadosomatic index and gonad histopathology of Gobius niger (Gobiidea, Teleost) from Bizerta lagoon (Tunisia): Evidence of reproduction disturbance

Gonadosomatic index and gonad histopathology of Gobius niger (Gobiidea, Teleost) from Bizerta lagoon (Tunisia): Evidence of reproduction disturbance

Testis morphology in rats chronically treated with letrozole, an aromatase inhibitor

Triorganotin as a compound with potential reproductive toxicity in mammals

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