Reduction of Some Functional Groups with Zirconium Tetrachloride/Sodium Borohydride

A Rapid and Practical Protocol for Solvent-Free Reduction of Oximes to Amines with NaBH4/ZrCl4/Al2O3System

“…Although the combination system of NaBH 4 and ZrCl 4 has been reported for reduction of oximes 12 or o-alkyl oxime ethers;…”

An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator

“…Though there are several procedures known, more efficient and convenient protocols are continously being explored. The reduction of carboxylic acids was achieved by a variety of metal hydride based reducing agents such as LiAlH 4 reported in the literature. BOP reagent was used to activate carboxylic group prior to NaBH 4 treatment.…”

Applications of Zirconium (IV) Compounds in Organic Synthesis

“…The reduction of C=O double bonds, C=N double bonds and C N triple bonds in THF at room temperature has been achieved using ZrCl 4 /NaBH 4 (Scheme 16) [58]. The procedure works well for aldehydes, ketones, carboxylic acids, carboxylic esters, acyl chlorides, carboxamides, oximes and nitriles.…”