Reduction of Skeletal Muscle Power in Adolescent Males Carrying H63D Mutation in the<i>HFE</i>Gene

Łuszczyk, Marcin; Kaczorowska-Hac, Barbara; Miłosz, Ewa; Adamkiewicz-Drożyńska, Elżbieta; Ziemann, Ewa; Laskowski, Radosław; Flis, Damian Józef; Rokicka-Hebel, Magdalena; Antosiewicz, Jędrzej

doi:10.1155/2017/5313914

Cited by 6 publications

(6 citation statements)

References 37 publications

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Section: Discussionmentioning

confidence: 99%

“…Despite the potential for improvements in athletic performance in those who possess the HFE risk variants, some studies have suggested otherwise (11,39). One study showed that male adolescents with one H63D risk variant ( n = 7) possessed lower aerobic capacity compared with those without the risk variants ( n = 6) (39). However, there are several limitations, such as a small sample size and different sport modalities being assessed, which could have influenced this result.…”

Section: Discussionmentioning

confidence: 99%

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HFE Genotype and Endurance Performance in Competitive Male Athletes

Thakkar

Sicova²,

Guest³

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Hereditary hemochromatosis can cause individuals to absorb too much iron from their diet. Higher tissue iron content, below the threshold of toxicity, may enhance oxygen carrying capacity and offer a competitive advantage. Single nucleotide polymorphisms (SNP) in the homeostatic iron regulator (HFE) gene have been shown to modify iron metabolism and can be used to predict an individual's risk of hemochromatosis. Several studies have shown that HFE genotypes are associated with elite endurance athlete status; however, no studies have examined whether HFE genotypes are associated with endurance performance. Purpose: The objectives of this study were to determine whether there was an association between HFE risk genotypes (rs1800562 and rs1799945) and endurance performance in a 10-km cycling time trial as well as maximal oxygen uptake (V ˙O2peak ), an indicator of aerobic capacity. Methods: Competitive male athletes (n = 100; age = 25 ± 4 yr) completed a 10-km cycling time trial. DNA was isolated from saliva and genotyped for the rs1800562 (C282Y ) and rs1799945 (H63D) SNP in HFE. Athletes were classified as low risk (n = 88) or medium/high risk (n = 11) based on their HFE genotype for both SNP using an algorithm. ANCOVA was conducted to compare outcome variables between both groups. Results: Individuals with the medium-or high-risk genotype were ~8% (1.3 min) faster than those with the low-risk genotype (17.0 ± 0.8 vs 18.3 ± 0.3 min, P = 0.05). V ˙O2peak was ~17% (7.9 mL•kg −1 ⋅min −1 ) higher in individuals with the medium-or high-risk genotype compared with those with the low-risk genotype (54.6 ± 3.2 vs 46.7 ± 1.0 mL•kg −1 ⋅min −1 , P = 0.003). Conclusion: Our findings show that HFE risk genotypes are associated with improved endurance performance and increased V ˙O2peak in male athletes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

HFE Genotype and Endurance Performance in Competitive Male Athletes

Thakkar

Sicova²,

Guest³

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Studies on the impact of HH on athletic performance are ambiguous. Some studies suggest that athletes with iron levels below the threshold of toxicity may exhibit enhanced athletic performance [12], while others indicate a reduction in athletic capabilities [9,13]. Nonetheless, it is well established that untreated HH can lead to organ damage, including the heart, skeletal muscles, and liver [8,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The IRONy in Athletic Performance

Kardasis,

Naquin,

Garg

et al. 2023

Nutrients

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Iron is an essential micronutrient for athletes, intricately linked to their performance, by regulating cellular respiration and metabolism. Impaired iron levels in the body can significantly hinder athletic performance. The increased demand for iron due to exercise, coupled with potential dietary iron insufficiencies, particularly among endurance athletes, amplifies the risk of iron deficiency. Moreover, prolonged exercise can impact iron absorption, utilization, storage, and overall iron concentrations in an athlete. On the contrary, iron overload may initially lead to enhanced performance; however, chronic excess iron intake or underlying genetic conditions can lead to detrimental health consequences and may negatively impact athletic performance. Excess iron induces oxidative damage, not only compromising muscle function and recovery, but also affecting various tissues and organs in the body. This narrative review delineates the complex relationship between exercise and iron metabolism, and its profound effects on athletic performance. The article also provides guidance on managing iron intake through dietary adjustments, oral iron supplementation for performance enhancement in cases of deficiency, and strategies for addressing iron overload in athletes. Current research is focused on augmenting iron absorption by standardizing the route of administration while minimizing side effects. Additionally, there is ongoing work to identify inhibitors and activators that affect iron absorption, aiming to optimize the body’s iron levels from dietary sources, supplements, and chelators. In summary, by refining the athletic diet, considering the timing and dosage of iron supplements for deficiency, and implementing chelation therapies for iron overload, we can effectively enhance athletic performance and overall well-being.

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“…HFE encodes a homeostatic iron regulator that regulates iron, and thus is linked to hemochromatosis [18]. Carriers of HFE polymorphisms have reduced peak oxygen uptake [19] and report tiredness or lack of energy [20]. MYBPC3 codes for the thick-filament-associated protein cardiac myosin-binding protein C, and thus is linked with muscle sarcomeric structure and its contraction and relaxation [21].…”

Section: Introductionmentioning

confidence: 99%

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Dzitkowska-Zabielska

Bojarczuk

Borczyk

et al. 2022

Genes

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Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30× mean coverage. Results: All the analyzed polymorphisms conformed to Hardy–Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers’ group. No significant between-group differences were found for analyzed polymorphisms. Conclusions: The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size.

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Reduction of Skeletal Muscle Power in Adolescent Males Carrying H63D Mutation in theHFEGene

Cited by 6 publications

References 37 publications

HFE Genotype and Endurance Performance in Competitive Male Athletes

HFE Genotype and Endurance Performance in Competitive Male Athletes

The IRONy in Athletic Performance

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

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