Abstract:Ribonucleosides are converted into 2'-deoxyribonucleosides in good yields by a four-step procedure. Selective protection of the 3'- and 5'-hydroxyl groups with 1,3-dichloro-1,1,3,3-tetraisopropyl-1,3-disiloxane is followed by functionalization of the 2'-hydroxyl group with phenoxythiocarbonyl chloride. Free radical-mediated reductive C2'-O2' bond cleavage of these 3',5'-O-TPDS-2'-O-PTC-nucleoside derivatives with tributyltin hydride, followed by removal of the silyl protecting group with tetrabutylammonium flu… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.