Reduction of relative handgrip strength and cardiometabolic risk in individuals with HIV/AIDS

Santos, Fabiana Brito; Conceição‐Machado, Maria Ester Pereira da; Sampaio, Ethiane de Jesus; Ramos, Lílian Barbosa; Barreto-Medeiros, Jairza Maria

doi:10.1590/0037-8682-0405-2018

Cited by 3 publications

(4 citation statements)

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“…18,34 In the present study, two pathways related to the understanding of HGS with body composition were verified: the first shows that the greater the lean mass, the greater the HGS; the second points to an inversely proportional principle, in which the greater the values of BMI, abdominal circumference, sum of skinfolds, percentage of fat, and fat mass, the lower the HGS. This response pattern is not limited to body composition; biochemical indicators such as total cholesterol, when altered, are also related to a lower HGS, as seen in the present study and confirmed by Santos et al 15 Thus, as muscle strength is an important component of health-related physical fitness, changes in body composition that reduce muscle strength directly impact the performance of activities of daily living and the functional capacity of people living with HIV. 4,35 Physical exercise programs for people living with HIV are important strategies to improve strength and muscle mass, which are negatively affected by both HIVand the use of antiretrovirals.…”

Section: Discussionsupporting

confidence: 89%

“…This response pattern is not limited to body composition; biochemical indicators such as total cholesterol, when altered, are also related to a lower HGS, as seen in the present study and confirmed by Santos et al 15 Thus, as muscle strength is an important component of health-related physical fitness, changes in body composition that reduce muscle strength directly impact the performance of activities of daily living and the functional capacity of people living with HIV. 4,35…”

Section: Discussionsupporting

confidence: 89%

“…12 Regular monitoring of handgrip strength may be an easy tool to assess muscle strength and aid in the early detection of dynapenia 13,14 and metabolic syndrome. 15 Thus, in clinical practice, regular monitoring of people living with HIV is important to detect and treat these morphofunctional disorders early.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of handgrip strength with health indicators of people living with HIV in west Pará, Brazil

et al. 2023

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Background Handgrip strength (HGS) is an important health indicator that can be influenced by body composition and biochemical markers of people living with HIV, contributing to better understanding of health-related outcomes. Objective To analyze the relationship between HGS and health indicators in people living with HIV. Methods Cross-sectional study, with 207 people living with HIV, attending a reference center, located in Santarém, Pará, Brazil. Data collection covered sociodemographic, clinical, laboratory, physical activity level, body composition, and HGS information. Data were analyzed using descriptive and inferential statistics, adopting p < .05. Results There was a predominance of men (60%), aged 33–47 years (42%). A relationship was observed between adequate HGS and the male sex ( p < .001), and adequate values for body mass index ( p = .003), abdominal circumference ( p < .001), and total cholesterol ( p = .012). In addition, higher values of fat mass ( p < .001), and lower lean mass ( p = .006) were observed for people living with HIV with low HGS. Conclusion People living with HIV present an association between lean body mass and high HGS. On the other hand, low HGS favored obesity and hypercholesterolemia. Thus, monitoring HGS is an important indicator of body, laboratory, and functional capacity changes, with HGS being an additional element in the clinical evaluation.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

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Relationship of handgrip strength with health indicators of people living with HIV in west Pará, Brazil

et al. 2023

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“…This finding is in line with that obtained in the above-mentioned study, suggesting that HIV infection plays a role in promoting dynapenia in untreated patients. Likewise, it should be considered that men and women may react differently to HIV infection and ART use, so women may have less muscle strength than men (45), as found in a previous study (37). Our analyzes were not stratified by gender, as only 19.5% of our sample consisted of women.…”

Section: Discussionmentioning

confidence: 85%

Effect of Antiretroviral Therapy With Tenofovir, Lamivudine And Dolutegravir On Respiratory And Peripheral Muscles Strengh In People Living With Hiv/Aids

Cardoso

Araújo

Maranhão

et al. 2019

Preprint

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Background Some antiretrovirals (ARVs) cause muscle toxicity and their use has been attributed to beginning of respiratory and peripheral muscle weakness in people living with HIV/AIDS (PLWHA) on treatment. Dolutegravir (DTG) has been adopted by Brazil as a first-line regimen with Tenofovir/Lamivudine (TDF/3TC) since 2017, with low toxicity profile. Due to the short use of this regimen, we have not found data in the literature regarding its effects in the respiratory and peripheral muscles in PLWHA. The aim of this study was to compare respiratory and peripheral muscle strength before and after start of this new combined ART (TDF/3TC/DTG).Methods Descriptive, longitudinal and prospective study, observational and analytical with 41 PLWHA evaluated before the initiation of antiretroviral therapy (ART) (T0) which of these, 28 were reevaluated after more than 50 days of treatment (T1).The assessments of maximum functional capacity (six-minute walk test distance), maximal inspiratory (MIP) and expiratory (MEP) pressures and handgrip strength (HGS) were performed using standardized methods. In addition, laboratory data (CD4, CD4/CD8 ratio and viral load-VL) were collected. Shapiro-Wilk test was applied for normality while Fisher's exact test and t-test or Wilcoxon test were used for comparisons of categorical and continuous variables, respectively. Pearson or Spearman correlations were used according to data normality and p-value < 0.05 were considered significant for all analyzes.Results The frequency of peripheral muscle weakness in patients evaluated at T0 was 97.6%, while 31.7% had inspiratory and / or expiratory muscle weakness. HGS was positively correlated with CD4 (p = 0.027) and negatively correlated with VL (p = 0.046). Both MIP (p = 0.0176) and HGS (p = 0.0018) showed improvement in T1.Conclusion ART combined with TDF / 3TC / DTG increased MIP and HGS after more than 50 days of treatment. Cohort studies are needed to better understand the action of these medications on PLWHA musculature under treatment.

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Relationship Between Handgrip Strength and Age in the Body Composition Variables Among People Living with HIV

Gouvêa-e-Silva

Silva

Araujo

et al. 2022

CHR

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Background: The study of aging, as well as handgrip strength (HGS) isimportant to gain knowledge for health care and quality of life in people living with HIV (PLHIV). Objective: The aim of the study is to analyze the relationship between HGS and age in the body composition variables of PLHIV. Methods: The sample consisted of 77 PLHIV, divided into three groups: G40 – PLHIV aged 40-49 years (n=39); G50 – PLHIV aged 50-59 years (n=26); and G60 – PLHIV aged 60-69 years (n=12). Data collection included anamnesis (sociodemographic, clinical, and laboratory information), physical assessment (body composition and HGS), and physical activity level. Data were analyzed by descriptive and inferential statistics. Results: It was noted that men, compared to women, are 5.85 times more likely to present adequate HGS (p<0.001). In addition, adequate HGS was associated with adequate values of body mass index (p<0.001), waist circumference (p<0.001), and fat percentage (p<0.001). The G40 and G50 groups, in relation to the G60, were associated with adequate abdominal circumference (p=0.04). Conclusion: Monitoring the evolution of HGS in PLHIV, over time, makes it possible to infer about body fat and muscle mass, in order to propose prevention actions and guidelines to prevent early muscle loss, the development of overweight/obesity, and abdominal obesity.

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Reduction of relative handgrip strength and cardiometabolic risk in individuals with HIV/AIDS

Cited by 3 publications

References 14 publications

Relationship of handgrip strength with health indicators of people living with HIV in west Pará, Brazil

Relationship of handgrip strength with health indicators of people living with HIV in west Pará, Brazil

Effect of Antiretroviral Therapy With Tenofovir, Lamivudine And Dolutegravir On Respiratory And Peripheral Muscles Strengh In People Living With Hiv/Aids

Relationship Between Handgrip Strength and Age in the Body Composition Variables Among People Living with HIV

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