Reduction of Postischemic Edema with Hyperbaric Oxygen

Nylander, G; Lewis, David; Nordstrom, Hans; Larsson, Jörgen; Davis, Jefferson C.

doi:10.1097/00006534-198510000-00022

Cited by 26 publications

(31 citation statements)

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“…HBOT is considered to contribute to wound healing by stimulating neovascularization and oxygen tissue diffusion and thus improving oxygen transport to the wound [13]. The effects of HBOT on infection are based on several mechanisms, including reinforcement of the bacterial killing capacity of neutrophils [14], alleviation of inflammation and edema [15], and reinforcement of antimicrobial drug efficacy [16] (reviewed by Hopf and Holm [17]). We will clarify the effects of HBOT in the prevention and treatment of SSI in future separate studies.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Surgical Site Infection after Musculoskeletal Tumor Surgery: Risk Assessment Using a New Scoring System

Nagano

Yokouchi

Setoguchi

et al. 2014

Sarcoma

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Surgical site infection (SSI) has not been extensively studied in musculoskeletal tumors (MST) owing to the rarity of the disease. We analyzed incidence and risk factors of SSI in MST. SSI incidence was evaluated in consecutive 457 MST cases (benign, 310 cases and malignant, 147 cases) treated at our institution. A detailed analysis of the clinical background of the patients, pre- and postoperative hematological data, and other factors that might be associated with SSI incidence was performed for malignant MST cases. SSI occurred in 0.32% and 12.2% of benign and malignant MST cases, respectively. The duration of the surgery (P = 0.0002) and intraoperative blood loss (P = 0.0005) was significantly more in the SSI group than in the non-SSI group. We established the musculoskeletal oncological surgery invasiveness (MOSI) index by combining 4 risk factors (blood loss, operation duration, preoperative chemotherapy, and the use of artificial materials). The MOSI index (0–4 points) score significantly correlated with the risk of SSI, as demonstrated by an SSI incidence of 38.5% in the group with a high score (3-4 points). The MOSI index score and laboratory data at 1 week after surgery could facilitate risk evaluation and prompt diagnosis of SSI.

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Section: Discussionmentioning

confidence: 99%

Analysis of Surgical Site Infection after Musculoskeletal Tumor Surgery: Risk Assessment Using a New Scoring System

Nagano

Yokouchi

Setoguchi

et al. 2014

Sarcoma

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“…Treatments are few in number (7)(8)(9)(10)(11)(12) with obvious and significant benefits: fewer complications, fewer new surgical procedures, better functional outcomes and reduced hospital stay.…”

Section: Resultsmentioning

confidence: 99%

“…This results in reduced hydrostatic pressure in the capillaries, with less fluid extravasation, while hyper-oxygenation continues. In the venules, interstitial fluid is absorbed, the end result being a rapid and significant reduction in oedema (10). This has important implications, particularly in trauma and burns.…”

Section: Vasoconstrictionmentioning

confidence: 99%

Hyperbaric Oxygen in Trauma and Surgical Emergencies

MacFarlane

Cronjé²,

Benn

2000

J R Army Med Corps

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Hyperbaric oxygen therapy (HBO), that is the administration of 100% oxygen delivered under pressure, has a beneficial effect in several surgical conditions. Its use has been assessed and audited and its pharmacological effects demonstrated. It is appropriate for use in several acute surgical conditions as evidence-based therapy. These are: Gas Gangrene Crush Injuries, Compartment Syndromes & Acute Traumatic Ischaemias Enhancement of Healing in Selected Problem Wounds Exceptional Blood loss Anaemia Necrotising Soft Tissue Infections Compromised Skin Grafts & Flaps Thermal Burns HBO therapy suffers from previous inappropriate use, lack of knowledge, and scarce hyperbaric facilities. Hyperbaric therapy, when properly supervised by a physician trained in its use, working closely with a surgeon, and ethically used for appropriate indications, can be a useful adjunct to surgical practice. Military surgeons may be in a situation in which they can utilize HBO in acute surgical conditions and trauma. They are urged to identify HBO facilities, both fixed and portable, and to establish communication with hyperbaric therapy colleagues.

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“…Der Anstieg des arteriellen Sauerstoffpartialdrucks führt zu einer reaktiven Vasokonstriktion. Der effektive kapilläre Filtrationsdruck wird reduziert, woraus eine antiödematöse Wirkung resultiert [14]. Die veränderten Perfusionsverhältnisse führen zu einem inversen Steal-Effekt mit einer verbesserten Oxygenierung mangelversorgter Gewebe [15].…”

Section: Dekompressionskrankheitunclassified