Reduction of Post-surgical Pericardial Adhesions Using a Pig Model

Abstract

We conclude that systemic Indomethacin, and locally applied Coseal are suitable methods to markedly reduce pericardial and retrosternal adhesions.

Binding of Anticell Adhesive Oxime‐Crosslinked PEG Hydrogels to Cardiac Tissues

“…This has been an issue with materials such as CoSeal®, [12] which swells 300-400% after application. [10, 13] …”

Comparison of Synthetic Glues and 10-0 Nylon in Rabbit Lamellar Keratoplasty

“…Coseal expands after polymerization and adheres to tissues that cells can use in their migration to the healing site. 10 In this study, most of the Tisseel dissolved; however, Beriplast P remained as a thin layer. Kroez et al 11 reported that Beriplast P degrades with a half-life of approximately 25 days after application.…”

Combined use of barrier methods to prevent pericardial adhesions: Is it always better?

“…Subsequently, normal pericardial mesothelial cell growth is observed on the surfaces free of adhesions. [1] Therefore, the basic methods studied to prevent adhesions include fibrinolytic agents, [2] anti-inflammatory agents, [3,4] permanent physical barriers which involve pericardial closure either directly or using an ePTFE membrane as a substitute [5,6] and resorbable barriers to prevent early fibrin deposition [7][8][9][10][11][12][13][14][15][16][17] N-acetyl cysteine have been also shown to reduce adhesions probably through fibroblast inhibition, since it is in liquid form the ideal method of application is still undetermined. [21] The closure of pericardium has been used as a barrier method to decrease the adhesions.…”

“…[1] Among these methods, fibrinolytic agents have caused serious postoperative bleeding in the initial trials [2] and were not, therefore, further studied. Although anti-inflammatory agents have been shown to be effective in the experimental studies, [3,4] their potential for systemic side effects is an important drawback for their widespread use. Permanent physical barriers involve pericardial closure and use of expanded polytetrafluoroethylene (ePTFE) membrane as a pericardial substitute.…”