Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

Collier, Scott R.; Sandberg, Kathryn; Moody, Anne Marie; Frechette, Vincent; Curry, Chelsea D.; Ji, Hong; Gowdar, R; Chaudhuri, Debanik; Meucci, Marco

doi:10.1038/jhh.2014.33

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…16 Increasing evidence of a role for aldosterone and MR signaling in development of arterial stiffness has emanated from multiple studies. 17–20 A recent clinical study reported an association between elevated serum aldosterone concentrations and increased aortic stiffening in normotensive overweight and obese adults aged 20 to 45 years. 21 Moreover, accumulating evidence suggests improvement in arterial elasticity occurs with administration of MR antagonists (MRA).…”

Section: Introductionmentioning

confidence: 99%

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice

et al. 2015

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Women are especially predisposed to development of arterial stiffening secondary to obesity due to consumption of excessive calories. Enhanced activation of vascular mineralocorticoid receptors impairs insulin signaling, induces oxidative stress, inflammation and maladaptive immune responses. We tested whether a sub-pressor dose of mineralocorticoid receptor antagonist, spironolactone (1 mg•kg−1•day−1) prevents aortic and femoral artery stiffening in female C57BL/6J mice fed a high fat/high sugar western diet (WD) for four months (i.e., from 4–20 weeks of age). Aortic and femoral artery stiffness were assessed using ultrasound, pressurized vessel preparations and atomic force microscopy. WD induced weight gain and insulin resistance compared to control diet-fed mice and these abnormalities were unaffected by spironolactone. Blood pressures and heart rates were normal and unaffected by diet or spironolactone. Spironolactone prevented WD-induced stiffening of aorta and femoral artery as well as endothelial and vascular smooth muscle cells within aortic explants. Spironolactone prevented WD-induced impaired aortic protein kinase B/endothelial nitric oxide synthase signaling, as well as, impaired endothelium-dependent and –independent vasodilation. Spironolactone ameliorated WD-induced aortic medial thickening and fibrosis and the associated activation of the pro-growth extracellular receptor kinase 1/2 pathway. Finally, preservation of normal arterial stiffness with spironolactone in WD-fed mice was associated with attenuated systemic and vascular inflammation and an anti-inflammatory shift in vascular immune cell marker genes. Low-dose spironolactone may represent a novel prevention strategy to attenuate vascular inflammation, oxidative stress, and growth pathway signaling and remodeling to prevent development of arterial stiffening secondary to consumption of a WD.

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Section: Introductionmentioning

confidence: 99%

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice

et al. 2015

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“…Aerobic exercise reduces blood pressure in hypertension people with central obesity due to the decrease of plasma aldosterone and pulse wave velocity that causes vasodilation (Collier et al, 2015). High intensity interval training (HIIT) induces an improvement in blood pressure through the dilatation process of blood vessels, thereby the blood flow to muscles increases along with the increase of exercise intensity and the regulation of the nervous system and hormones in form of decreased norepinephrine levels at rest (Ciolac et al, 2010;Ciolac et al, 2011;Ramos et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Blood Pressure and Body Composition in Hypertensive Adults with Central Obesity

Adriyani¹,

Iskandar²,

Dana³

2021

J. pendidik. jasmani olahraga

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Regular exercise is recommended for adults experiencing hypertension with low and moderate cardiovascular risk. High intensity interval training (HIIT) is an efficient training method and has a better cardiometabolic protective effect. The purpose of this study was to determine sex differences in blood pressure and body composition after high intensity interval training. Twenty two adults with hypertension and central obesity (male n = 16, age 35.56 ± 4.56 years, waist circumference 98.85 ± 6.85 cm, systolic blood pressure 134.22 ± 2.86 mmHg, diastolic blood pressure 85.03 ± 6.58 mmHg) - (female n = 6, age 37.83 ± 5.46 years, waist circumference 95.09 ± 7.49 cm, systolic blood pressure 133.50 ± 6.47 mmHg, diastolic blood pressure 89.80 ± 5.94 mmHg) participated in a high intensity interval training (HIIT). The HIIT consisted of 3x4 minutes training at 77– 95% of maximum heart rate interspersed by 3 minutes of active rest at 64-76% of of maximum heart rate. The training was conducted three sessions per week for 10 weeks. Systolic blood pressure and diastolic blood pressure were significantly reduced in men. There was an improvement in body composition parameters, including a decrease in waist-to-hip ratio, visceral fat, and body fat mass in men (p 0.05). Waist circumference decreased in both men and women (p 0.05). It concludes that there are sex differences in cardiometabolic adaptation after HIIT.

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“…Prior studies analyzing the relationship between aldosterone and physical activity have been inconclusive. Some studies reveal that physical activity in the form of aerobic exercise decreases aldosterone levels [42,43], while others have shown no effect of aerobic exercise on aldosterone [44,45]. Interestingly, there may be racial/ethnic differences with one study revealing lower aldosterone after aerobic exercise training among whites but not AAs [44].…”

Section: Discussionmentioning

confidence: 99%

The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study

et al. 2019

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Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life’s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs. Thus, we investigated the association of LS7 metrics with aldosterone in the Jackson Heart Study (JHS). Methods: Ideal metrics were defined by AHA 2020 goals for health behaviors (smoking, dietary intake, physical activity, and body mass index) and health factors (total cholesterol, blood pressure, and fasting glucose). The number of ideal LS7 metrics attained at baseline were summed into a continuous score (0–7) and categorical groups (Poor: 0–1, Intermediate: 2–3, and Ideal: ≥4 ideal LS7 metrics). Multivariable linear regression was used. Results: Among 4,095 JHS participants (mean age 55 ± 13 years, 65% female), median serum aldosterone was 4.90, 4.30, and 3.70 ng/dL in the poor (n = 1132), intermediate (n = 2288) and ideal (n = 675) categories respectively. Aldosterone was 15% [0.85 (0.80, 0.90)] and 33% [0.67 (0.61, 0.75)] lower in the intermediate and ideal LS7 categories compared to the poor LS7 category. Each additional LS7 metric attained on continuous LS7 score (0–7) was associated with an 11% [0.89 (0.86, 0.91)] lower aldosterone level with variation by sex with women having a 15% lower aldosterone vs. 5% in men. Conclusions: Higher attainment of ideal LS7 metrics was associated with lower serum aldosterone among AAs with a greater magnitude of association among women compared to men.

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Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

Cited by 21 publications

References 37 publications

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice

Sex Differences in Blood Pressure and Body Composition in Hypertensive Adults with Central Obesity

The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study

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