Reduction of Particles in the Operating Room Using Ultraviolet Air Disinfection and Recirculation Units

Curtis, Gannon L.; Faour, Mhamad; Jawad, Michael; Klika, Alison K.; Barsoum, Wael K.

doi:10.1016/j.arth.2017.11.052

Cited by 33 publications

(34 citation statements)

References 30 publications

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“…The C‐UVC unit was placed in the OR, 2 m from the surgical table and 8 m from the door to the substerile corridor (i.e., source of air contamination). A previous study has shown an arrangement with the C‐UVC unit 4–8 m from the substerile corridor to be effective at reducing particle counts in a controlled OR setting . Air enters at the bottom of the unit, passes through the filter where airborne microogranisms are exposed to C‐UVC, and then flows out through the clean air exhaust at the top of the unit (Fig.…”

Section: Methodsmentioning

confidence: 99%

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In‐Room Ultraviolet Air Filtration Units Reduce Airborne Particles During Total Joint Arthroplasty

Anis

Curtis

Klika

et al. 2019

Journal Orthopaedic Research

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Reducing airborne bioburden in total joint arthroplasty (TJA) is of critical importance. The efficacy of crystalline ultraviolet-C (C-UVC) filtration in reducing bioburden in a dynamic operating room (OR) environment has not been evaluated. We assessed whether C-UVC filtration reduced (i) total particle counts (TPC); (ii) viable particle counts (VPC); and (iii) colony-forming units (CFUs). Fifty primary TJA cases were performed in a positive-pressure OR; 25 cases with the C-UVC unit and 25 cases without. The air was sampled by a particle counter and an impact air sampler to measure particle counts and CFUs, respectively. To compare TPC, VPC, and CFU/m 3 between groups, independent t tests and multivariate regression, adjusted for number of OR staff and door openings, were performed. The C-UVC group had significantly lower TPC (2.6 × 10 6 vs. 4.7 × 10 6 particles, p = 0.001) and VPC (18,605 vs. 27,516 particles, p = 0.001). There were fewer CFUs in the C-UVC group (10.9 CFU/m 3 vs. 13.7 CFU/m 3 , p = 0.163). Multivariate analysis identified C-UVC filtration as a significant predictor of decreased TPC (β = −0.44, p = 0.002) and VPC (β = −0.47, p = 0.001) after accounting for door openings and number of OR staff. The reduction in CFUs was not significant on multivariate analysis. In this prospective pilot study, a C-UVC air disinfection and recirculation unit led to a significant reduction in both TPC and VPC and a non-significant reduction in CFU. Statement of clinical significance: Further studies are needed to investigate the effects of C-UVC filtration units on surgical-site infection rates.

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Section: Methodsmentioning

confidence: 99%

“…C‐UVC disinfection and recirculation units have previously shown to reduce particle counts in a strictly controlled OR setting; however, its efficacy in doing so in a dynamic operating environment has not been assessed. Furthermore, the ability of C‐UVC filtration to reduce airborne bacteria has not been assessed with traditional bacterial plating methods.…”

mentioning

confidence: 99%

In‐Room Ultraviolet Air Filtration Units Reduce Airborne Particles During Total Joint Arthroplasty

Anis

Curtis

Klika

et al. 2019

Journal Orthopaedic Research

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“…The device runs continuously during a procedure without an operator present and does not create any air turbulence or disruption of the OR air balance …”

Section: Adjunctive or Air Cleaning Technologymentioning

confidence: 99%

“…Several conference reports and one laboratory pilot study have described the efficacy and benefits of OR air cleaning technology using HEPA filtration plus UV‐C disinfection. At the 2017 Australasian College for Infection Prevention and Control annual conference, Walsh reported that air filtration and disinfection units that combine HEPA filtration and UV‐C disinfection technologies significantly reduced the total and viable particle counts in a highly controlled OR setting.…”

Section: Adjunctive or Air Cleaning Technologymentioning

confidence: 99%

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OR Air Quality: Is It Time to Consider Adjunctive Air Cleaning Technology?

Barnes¹,

Twomey²,

Carrico³

et al. 2018

AORN Journal

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Patients undergoing surgery may be at risk for infection from airborne particles such as dust, skin scales, respiratory aerosols, and hair fibers emanating from multiple sources in the OR, including personnel, heater‐cooler devices, and surgical smoke. This risk is increased in surgical patients undergoing procedures involving implanted devices. Surgical personnel also are at risk from exposure to surgical smoke, which can contain viable viral particles including human papillomavirus infection. Air quality in the OR is improved by engineering controls (eg, maintaining positive pressure). During the past decade, innovations in the field of adjunctive technology designed to improve OR air quality include using ultraviolet disinfection and mobile ultraviolet disinfection plus high‐efficiency particulate air filtration. Some of these technologies additionally provide continuous monitoring of circulating air particle counts. Additional research regarding the benefits of adjunctive air‐cleaning technology in the OR is warranted.

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Circular dichroism and UV–Vis detection of UV‐induced damage to nucleic acids

Dowling,

Carroll,

Kirschman

et al. 2023

Chirality

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In this report, we demonstrate that CD spectroscopy can be used as a tool to detect changes to DNA upon irradiation with UV light. We follow the spectroscopic response of DNA samples irradiated at selected exposure times with both CD and UV–Vis spectroscopy. We analyzed four different nucleic acids to evaluate the effect of the sequence on photodegradation. Only one polymer, calf thymus DNA, was a natural nucleic acid and contained all four nucleobases. The other three were synthetic polymers and contained only one type of base pair: poly (deoxyadenylic‐deoxythymidylic) acid [poly (dA‐dT)2] and poly (deoxyadenylic acid) · poly (deoxythymidylic acid) [poly (dA) · poly (dT)], which contained only adenine and thymine; poly (deoxyguanylic‐deoxycytidylic) acid [poly (dG‐dC)2], which contained only guanine and cytosine. CD and UV–Vis spectra showed sequence dependent changes. In particular, poly (dA) · poly (dT) undergoes changes more rapidly than the other sequences investigated. The CD spectrum of poly (dA) · poly (dT) gradually undergoes an inversion, suggesting a change in helicity, before disappearing due to the unfolding of the double strand.

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Reduction of Particles in the Operating Room Using Ultraviolet Air Disinfection and Recirculation Units

Cited by 33 publications

References 30 publications

In‐Room Ultraviolet Air Filtration Units Reduce Airborne Particles During Total Joint Arthroplasty

In‐Room Ultraviolet Air Filtration Units Reduce Airborne Particles During Total Joint Arthroplasty

OR Air Quality: Is It Time to Consider Adjunctive Air Cleaning Technology?

Circular dichroism and UV–Vis detection of UV‐induced damage to nucleic acids

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